DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dnt and Erbb4

DIOPT Version :9

Sequence 1:	NP_001260567.1	Gene:	dnt / 35207	FlyBaseID:	FBgn0024245	Length:	584	Species:	Drosophila melanogaster
Sequence 2:	NP_067719.2	Gene:	Erbb4 / 59323	RGDID:	620486	Length:	1308	Species:	Rattus norvegicus

Alignment Length:	771	Identity:	159/771 - (20%)
Similarity:	264/771 - (34%)	Gaps:	265/771 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VNKC------GKSASTRNCTVKMSRKMWV-----------LSLLALAALQLHSGSEVAA------ 45
            |.||      ..|:..|.|.   |.||.|           ..:...|...:.:||.::|
  Rat   290 VKKCPHNFVVDSSSCVRACP---SSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSS 351

  Fly    46 HLNVFLNPVE-----VMRLLGVSAEVY---------------YVRE--GHINNYALNFIVPVPAN 88
            :::.|:|..:     :..:.|:..:.|               .|||  |.:|      |...|.|
  Rat   352 NIDKFINCTKINGNLIFLVTGIHGDPYNAIDAIDPEKLNVFRTVREITGFLN------IQSWPPN 410

  Fly    89 VKDISF--TWQSLAGRGLPYSINVVSSDQE---VLPRPAINVSHSGEIPTTIQT---------WS 139
            :.|.|.  ...::.||.|...::::...|:   .|...::....:|.|..|..:         |:
  Rat   411 MTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWT 475

  Fly   140 IALKCSGLKAAEVDVTVSLEVVL--NRSLNNVT-------HLV------------------FRRK 177
            ....           ||:..:|:  ||...|.|       ||.                  |.|.
  Rat   476 TLFS-----------TVNQRIVIRDNRRAENCTAEGMVCNHLCSNDGCWGPGPDQCLSCRRFSRG 529

  Fly   178 KICLMN--------------------DSAEDLSED-------------------VDDPQLLETVM 203
            |||:.:                    ||..:..||                   .|.|..:|..
  Rat   530 KICIESCNLYDGEFREFENGSICVECDSQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKC- 593

  Fly   204 LPPTGLITLVVGVSVAMGSVCLLLMIAYCVKGAANKRQHHQHGGQPMRTSSFQRLNTHPPC-QSS 267
              |.||    .|.:            ::..|.|...|:.|.               .||.| |..
  Rat   594 --PDGL----QGAN------------SFIFKYADQDRECHP---------------CHPNCTQGC 625

  Fly   268 MGSAAY-----------------MTPSIIAPIHG------------------SSLPRK------- 290
            .|..::                 .||.|.|.:.|                  .|:.:|
  Rat   626 NGPTSHDCIYYPWTGHSTLPQHARTPLIAAGVIGGLFILVIMALTFAVYVRRKSIKKKRALRRFL 690

  Fly   291 -----VPVSVEQQHPEELHRRI-SELTVERCRVRLSSLLQEGTFGRVYRGTYNDTQD-----VLV 344
                 .|::.....|.:...|| .|..::|.:|     |..|.||.||:|.:....:     |.:
  Rat   691 ETELVEPLTPSGTAPNQAQLRILKETELKRVKV-----LGSGAFGTVYKGIWVPEGETVKIPVAI 750

  Fly   345 KTVAQHASQMQVLLLLQEGMLLYGASHPGILSVLGVSIEDHTTPFVLYPALNNTRNLKQFLLDPA 409
            |.:.:.......:..:.|.:::....||.::.:|||             .|:.|..|...|:...
  Rat   751 KILNETTGPKANVEFMDEALIMASVDHPHLVRLLGV-------------CLSPTIQLVTQLMPHG 802

  Fly   410 C--------ARTVTTIQIVMMASQLSMALDHLHSHGVVHKDIATRNCVIDDQLRVKLSDSSLSRD 466
            |        ...:.:..::....|::..:.:|....:||:|:|.||.::.....||::|..|:|
  Rat   803 CLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLAR- 866

  Fly   467 LFPSD---YNCLGDSENRPVKWMSLEALQHKQFSEASDSWAFGVLMWELCTSAKQPYAEVDPFEM 528
            |...|   ||  .|....|:|||:||.:.:::|:..||.|::||.:|||.|...:||..:...|:
  Rat   867 LLEGDEKEYN--ADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREI 929

  Fly   529 EHYLKDGYRLAQPFNCPDELFTIMAYCWALLPAERPTFAQLQSCLSEFYSQITRYV 584
            ...|:.|.||.||..|..:::.:|..||.:....||.|.:|.:..|.......||:
  Rat   930 PDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYL 985

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dnt	NP_001260567.1	WIF	46..182	CDD:128745	37/198 (19%)
		PKc_like	310..580	CDD:304357	74/285 (26%)
		Pkinase_Tyr	317..573	CDD:285015	72/271 (27%)
Erbb4	NP_067719.2	Recep_L_domain	55..167	CDD:395817
		Furin-like	186..332	CDD:395614	10/44 (23%)
		Recep_L_domain	358..478	CDD:395817	22/125 (18%)
		GF_recep_IV	502..634	CDD:405525	27/165 (16%)
		TM_ErbB4	642..685	CDD:213053	7/42 (17%)
		Nuclear localization signal. /evidence=ECO:0000250	676..684		1/7 (14%)
		PTKc_HER4	710..1012	CDD:173655	79/297 (27%)
		PPxy motif 1	1032..1035
		PPxY motif 2	1298..1301
		PDZ-binding	1306..1308
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900