DRSC/TRiP Functional Genomics Resources

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Protein Alignment dnt and fgfr3

DIOPT Version :10

Sequence 1:NP_477341.2 Gene:dnt / 35207 FlyBaseID:FBgn0024245 Length:584 Species:Drosophila melanogaster
Sequence 2:XP_009305459.1 Gene:fgfr3 / 58129 ZFINID:ZDB-GENE-000816-1 Length:820 Species:Danio rerio


Alignment Length:680 Identity:146/680 - (21%)
Similarity:253/680 - (37%) Gaps:195/680 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    55 EVMRLLGVSAE---VYYVREGH----INNYALNFIVPVPANVKDISFTWQSLAGRG---LPYSIN 109
            :.:|::.||.|   ||..|..|    ::||.:..|..:.:...:.....:..||.|   .||...
Zfish   103 KALRIINVSYEDSGVYSCRHAHKSMLLSNYTVKVIDSLSSGDDEDYDEDEDEAGNGNAEAPYWTR 167

  Fly   110 VVSSDQEVLPRPAINV---------------------------SHSGEIPTTIQTWSIALK---- 143
            ....::::|..||.|.                           ...|.|....|.||:.::    
Zfish   168 SDRMEKKLLAVPAANTVKFRCPAAGNPTPSIHWLKNGKEFKGEQRMGGIKLRDQQWSLVMESAVP 232

  Fly   144 -------C----------------------------SGLKAAEVDVTVS---------------- 157
                   |                            :||.|.:..|..|                
Zfish   233 SDRGNYTCVVQNKYGTIKHTYQLDVLERSPHRPILQAGLPANQTVVVGSDVEFHCKVYSDAQPHI 297

  Fly   158 -----LEV--------------VLNRSLNNVTHLVFRRKKICLMNDSAEDLSE---------DVD 194
                 :||              ||...::||..   .:..:.:.|.|.:|..:         .:.
Zfish   298 QWLKHIEVNGSQYGPNGAPYVNVLKSFVSNVKE---AQDTLTVYNVSEKDAGQYWCRAHNFLGMS 359

  Fly   195 DPQLLETVMLPPTGL------ITLVVGVSVAMGSVCLLLMIAYCVKGAANKRQHHQHGGQPMRTS 253
            :.....||..|...:      ..:::.|:..:..:..:::|..|......::.......|.:...
Zfish   360 ENSFWLTVSQPAVEMEREDDYADILIYVTSCVLFILTMVIIILCRMWINTQKTLPAPPVQKLSKF 424

  Fly   254 SFQRLNTHPPCQSSMGSAAYMTPSI-IAPIHGSSLPRKVPVSVEQQHPEELHRRISELTVERCRV 317
            ..:|........|||.|   .||.: ||.:..|..|....|| |.:.|.:     .:....|.::
Zfish   425 PLKRQQVSLESNSSMNS---NTPLVRIARLSSSDGPMLPNVS-ELELPSD-----PKWEFTRTKL 480

  Fly   318 RLSSLLQEGTFGRVYR-------------------------GTYNDTQDVLVKTVAQHASQMQVL 357
            .|...|.||.||:|..                         ||..|..|::        |:|:::
Zfish   481 TLGKPLGEGCFGQVVMAEAIGIDKEKPNKPLTVAVKMLKDDGTDKDLSDLV--------SEMEMM 537

  Fly   358 LLLQEGMLLYGASHPGILSVLGVSIEDHTTPFVLYPALNNTRNLKQFL-------LD---PACA- 411
            .::        ..|..|:::||...:|  .|..:.....:..||:::|       :|   ..|. 
Zfish   538 KMI--------GKHKNIINLLGACTQD--GPLYVLVEYASKGNLREYLRARRPPGMDYSFDTCKI 592

  Fly   412 --RTVTTIQIVMMASQLSMALDHLHSHGVVHKDIATRNCVIDDQLRVKLSDSSLSRDLFPSDYNC 474
              .|:|...:|..|.|::..:::|.|...:|:|:|.||.::.:...:|::|..|:||:...||..
Zfish   593 PNETLTFKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNIDYYK 657

  Fly   475 LGDSENRPVKWMSLEALQHKQFSEASDSWAFGVLMWELCTSAKQPYAEVDPFEMEHYLKDGYRLA 539
            ...:...|||||:.|||..:.::..||.|::|||:||:.|....||..:...|:...||:|:|:.
Zfish   658 KTTNGRLPVKWMAPEALFDRVYTHQSDVWSYGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMD 722

  Fly   540 QPFNCPDELFTIMAYCWALLPAERPTFAQL 569
            :|.||..||:.||..||..:|::||||.||
Zfish   723 KPANCTHELYMIMRECWHAVPSQRPTFRQL 752

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dntNP_477341.2 WIF 46..182 CDD:128745 37/237 (16%)
Protein Kinases, catalytic domain 310..580 CDD:473864 84/298 (28%)
fgfr3XP_009305459.1 Ig 46..120 CDD:472250 6/16 (38%)
Ig strand B 70..74 CDD:409353
Ig strand C 82..86 CDD:409353
Ig strand E 103..107 CDD:409353 0/3 (0%)
IgI_2_FGFR 163..257 CDD:409443 12/93 (13%)
Ig strand A 163..166 CDD:409443 2/2 (100%)
Ig strand A' 174..179 CDD:409443 1/4 (25%)
Ig strand B 183..191 CDD:409443 0/7 (0%)
Ig strand C 197..202 CDD:409443 0/4 (0%)
Ig strand C' 205..207 CDD:409443 0/1 (0%)
Ig strand D 216..219 CDD:409443 1/2 (50%)
Ig strand E 223..228 CDD:409443 2/4 (50%)
Ig strand F 237..244 CDD:409443 1/6 (17%)
Ig strand G 247..257 CDD:409443 0/9 (0%)
IgI_3_FGFR 265..366 CDD:409363 14/103 (14%)
Ig strand A 265..268 CDD:409363 0/2 (0%)
Ig strand A' 272..276 CDD:409363 1/3 (33%)
Ig strand B 284..291 CDD:409363 0/6 (0%)
Ig strand C 295..302 CDD:409363 0/6 (0%)
Ig strand D 317..322 CDD:409363 1/4 (25%)
Ig strand E 333..338 CDD:409363 0/4 (0%)
Ig strand F 346..354 CDD:409363 0/7 (0%)
Ig strand G 357..365 CDD:409363 0/7 (0%)
PTKc_FGFR3 467..800 CDD:173652 85/309 (28%)
Blue background indicates that the domain is not in the aligned region.

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