Protein Alignment dnt and ryk

DIOPT Version :10

• Sequence 1: NP_477341.2
• Gene: dnt / 35207
• FlyBaseID: FBgn0024245
• Length: 584
• Species: Drosophila melanogaster
• Sequence 2: XP_005165988.1
• Gene: ryk / 558502
• ZFINID: ZDB-GENE-070209-277
• Length: 632
• Species: Danio rerio
• Alignment Length: 597
• Identity: 218/597 - (36%)
• Similarity: 319/597 - (53%)
• Gaps: 81/597 - (13%)

  Fly    46 HLNVFLNPVEVMRLLGVSAEVYYVREGHINNYALNFIVPVPANVKDISFTWQSLAGRGLPYSINV 110
            ::|:|::..||.:|||:.||:||||:..:|:|||:|::|||::...:.|||.|  ...:.|.:..
Zfish    59 NVNIFMSEEEVKKLLGLDAELYYVRDDVVNHYALSFVLPVPSDTNSLHFTWHS--SSKVDYRLGF 121

  Fly   111 VSSDQEVLPRPAINVSHSGEIPTTIQTWSIALKCSGLKAAEVDVTVSLEVVLNRSLNNVTHLVFR 175
            ...:...:.:|..|:|..||:|.|...:.:.|.|||....|..:||.|.:   .:..|.|.|.|:
Zfish   122 HVENTSAMDQPQSNISVQGEVPRTRSVFRVDLFCSGKADGEAVLTVQLNL---STAANFTVLNFK 183

  Fly   176 RKKICLMNDSAEDLSEDVDDPQLLETVMLPPTGLITL--------VVGVSVAMGSVCLLLMIAYC 232
            |:|:|...         ::.|:..:|:..|.|.:..:        .....|...|||:..::.:.
Zfish   184 RRKMCYRR---------IEQPEPPKTLPFPNTTIQRIDASSPNAPTTSTRVFYISVCVCCIVIFL 239

  Fly   233 VKGAANKRQHHQHG-------------------GQP-MRTSSFQRL----NTHPPCQSSMGSAAY 273
            |  |......|.|.                   .|| .:|:.:.|.    |..|...:..|||..
Zfish   240 V--AIILAVLHLHSMKRVEMDDSVSDSGSSQGLSQPSTQTTQYLRADTPNNATPVTNAQTGSAPM 302

  Fly   274 MTPSIIAPIHGSSLPRK-VPVSVEQQHPE--------------ELHRRISELTVERCRVRLSSLL 323
            :      .:.|:|.|.. .|....:.:|.              |...::.::.:.|.||.|..:|
Zfish   303 L------QLAGASFPHPGAPSHETKSYPSLRIEKNDLRSVTLLEAKAKVKDIAISRERVTLRDVL 361

  Fly   324 QEGTFGRVYRGTYNDTQD------VLVKTVAQHASQMQVLLLLQEGMLLYGASHPGILSVLGVSI 382
            .||||||::.|...|.:|      |.||.|..|||::||.::|.|...|.|..|..:|.:..|.|
Zfish   362 HEGTFGRIFHGVLLDEKDPSKEKQVFVKAVKDHASEVQVTMMLTESCKLRGLHHRNLLPISHVCI 426

  Fly   383 EDHTTPFVLYPALNNTRNLKQFLLDPACA-----RTVTTIQIVMMASQLSMALDHLHSHGVVHKD 442
            ||...|.||.|.: |..|||.||.....|     :.::...:|.||.|:|..:.:|....|:|||
Zfish   427 EDGEKPMVLLPYM-NWGNLKLFLRQCKLAEANNPQAISQQDLVHMAIQISCGMSYLARREVIHKD 490

  Fly   443 IATRNCVIDDQLRVKLSDSSLSRDLFPSDYNCLGDSENRPVKWMSLEALQHKQFSEASDSWAFGV 507
            :|.||||||:.::||::|::|:|||||.||:||||:|||||:||:||:|.:..||.|||.|||||
Zfish   491 LAARNCVIDNSMQVKITDNALARDLFPMDYHCLGDNENRPVRWMALESLLNNDFSSASDVWAFGV 555

  Fly   508 LMWELCTSAKQPYAEVDPFEMEHYLKDGYRLAQPFNCPDELFTIMAYCWALLPAERPTFAQLQSC 572
            .:|||.|..:.||.::|||||..|||||||:|||.|||||||.:||.||||.|.|||.|.||..|
Zfish   556 TLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQC 620

  Fly   573 LSEFYSQITRYV 584
            |:||::.:..||
Zfish   621 LTEFHAALGAYV 632

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dnt	NP_477341.2	WIF	46..182	CDD:128745	48/135 (36%)
		Protein Kinases, catalytic domain	310..580	CDD:473864	141/280 (50%)
ryk	XP_005165988.1	WIF	63..184	CDD:460414	44/125 (35%)
		PTK_Ryk	348..628	CDD:270639	141/280 (50%)