DRSC/TRiP Functional Genomics Resources

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Protein Alignment dnt and AXL

DIOPT Version :10

Sequence 1:NP_477341.2 Gene:dnt / 35207 FlyBaseID:FBgn0024245 Length:584 Species:Drosophila melanogaster
Sequence 2:NP_068713.2 Gene:AXL / 558 HGNCID:905 Length:894 Species:Homo sapiens


Alignment Length:475 Identity:118/475 - (24%)
Similarity:209/475 - (44%) Gaps:117/475 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   156 VSLEVVLNRSLNNVTHLVFRRKKICLMNDSAEDLSEDVDDPQLL----------------ETVML 204
            |:||:..:.|::|:|        :|:...:|..     |.|..|                :.|..
Human   389 VTLELQGDGSVSNLT--------VCVAAYTAAG-----DGPWSLPVPLEAWRPGQAQPVHQLVKE 440

  Fly   205 PPTGLIT-----LVVGVSVAMGSVCLLLMIAYCVKGAANKRQHHQHGGQPMRTS----------- 253
            |.|...:     :::|..||  :.|:|::..:.|    ::|:.....|:....:           
Human   441 PSTPAFSWPWWYVLLGAVVA--AACVLILALFLV----HRRKKETRYGEVFEPTVERGELVVRYR 499

  Fly   254 ---SFQRLNTHPPCQSSMGSAAYMTPSIIAPIHGSSLPRKVPVSVEQQHPEELHRRISELTVERC 315
               |:.|..|.... :|:|.:                             |||..::.::.|:|.
Human   500 VRKSYSRRTTEATL-NSLGIS-----------------------------EELKEKLRDVMVDRH 534

  Fly   316 RVRLSSLLQEGTFGRVYRGTYNDTQDVL---VKTVAQHASQMQVLL--------LLQEGMLLYGA 369
            :|.|...|.||.||.|..|..|....:|   |||       |::.:        .|.|.:.:...
Human   535 KVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKT-------MKIAICTRSELEDFLSEAVCMKEF 592

  Fly   370 SHPGILSVLGVSI-----EDHTTPFVLYPALNNTRNLKQFLL------DPACARTVTTIQIVMMA 423
            .||.::.::||..     |....|.|:.|.:.: .:|..|||      .|.   .:.|..:|...
Human   593 DHPNVMRLIGVCFQGSERESFPAPVVILPFMKH-GDLHSFLLYSRLGDQPV---YLPTQMLVKFM 653

  Fly   424 SQLSMALDHLHSHGVVHKDIATRNCVIDDQLRVKLSDSSLSRDLFPSDYNCLGDSENRPVKWMSL 488
            :.::..:::|.:...:|:|:|.|||::::.:.|.::|..||:.::..||...|.....||||:::
Human   654 ADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAI 718

  Fly   489 EALQHKQFSEASDSWAFGVLMWELCTSAKQPYAEVDPFEMEHYLKDGYRLAQPFNCPDELFTIMA 553
            |:|..:.::..||.|:|||.|||:.|..:.||..|:..|:..||:.|.||.||.:|.|.|:.:|:
Human   719 ESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMS 783

  Fly   554 YCWALLPAERPTFAQLQSCL 573
            .||.|.|.:||:|.:|:..|
Human   784 RCWELNPQDRPSFTELREDL 803

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dntNP_477341.2 WIF 46..182 CDD:128745 7/25 (28%)
Protein Kinases, catalytic domain 310..580 CDD:473864 88/286 (31%)
AXLNP_068713.2 interaction with Gas6 26..92
IgI_1_Axl_like 35..135 CDD:409558
Ig strand A 35..40 CDD:409558
Ig strand A' 43..46 CDD:409558
Ig strand B 50..60 CDD:409558
Ig strand C 66..71 CDD:409558
Ig strand C' 74..76 CDD:409558
Ig strand D 81..88 CDD:409558
Ig strand E 95..106 CDD:409558
Ig strand F 113..121 CDD:409558
Ig strand G 124..135 CDD:409558
IgI_2_Axl_Tyro3_like 140..222 CDD:409407
Ig strand A 140..143 CDD:409407
Ig strand A' 146..150 CDD:409407
Ig strand B 154..163 CDD:409407
Ig strand C 168..175 CDD:409407
Ig strand C' 177..180 CDD:409407
Ig strand E 186..197 CDD:409407
Ig strand F 200..209 CDD:409407
Ig strand G 213..222 CDD:409407
FN3 225..328 CDD:238020
fn3 335..418 CDD:394996 10/41 (24%)
PTKc_Axl 535..811 CDD:270660 86/280 (31%)
Blue background indicates that the domain is not in the aligned region.

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