DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dnt and erbb3b

DIOPT Version :9

Sequence 1:	NP_001260567.1	Gene:	dnt / 35207	FlyBaseID:	FBgn0024245	Length:	584	Species:	Drosophila melanogaster
Sequence 2:	NP_001014826.1	Gene:	erbb3b / 544664	ZFINID:	ZDB-GENE-050107-1	Length:	1429	Species:	Danio rerio

Alignment Length:	303	Identity:	83/303 - (27%)
Similarity:	151/303 - (49%)	Gaps:	24/303 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   294 SVEQQHPEELHRRISELTVERCRVRLSSLLQEGTFGRVYRGTYNDTQD-----VLVKTVAQHASQ 353
            |:|...|.|...::....::...:|...||..|.||.|.:|.:....|     |.:||: |:.|.
Zfish   687 SMEPLDPGEKGTKVHARILKPQELRKGKLLGYGVFGTVNKGFWIPEGDSLKIPVAIKTI-QNRSS 750

  Fly   354 MQVLLLLQEGMLLYGA-SHPGILSVLGV----SIEDHTTPFVLYPALNNTRNLKQF--LLDPACA 411
            .|....:.:.||..|: .||.|:.::|:    |::..|.   |.|..:..::|:|.  .|||.
Zfish   751 RQTFTEITDHMLSMGSLDHPYIVRLIGICPGASLQLITQ---LSPHGSLLQHLRQHKDSLDPQ-- 810

  Fly   412 RTVTTIQIVMMASQLSMALDHLHSHGVVHKDIATRNCVIDDQLRVKLSDSSLSRDLFPSDYNCLG 476
                  :::....|::..:.:|..|.:.|:::|.||.::.....|::||..::..|:|.|...:.
Zfish   811 ------RLLNWCVQIAKGMYYLEEHCMAHRNLAARNILLKSDYIVQISDFGVADLLYPDDKKYVY 869

  Fly   477 DSENRPVKWMSLEALQHKQFSEASDSWAFGVLMWELCTSAKQPYAEVDPFEMEHYLKDGYRLAQP 541
            ......:|||:||::...:::..||.|::||.:||:.:...:|||.:.|.::...|:.|.|||||
Zfish   870 SEHKTSIKWMALESILFGRYTHQSDVWSYGVTVWEMMSYGAEPYASMHPHDVPGLLEKGERLAQP 934

  Fly   542 FNCPDELFTIMAYCWALLPAERPTFAQLQSCLSEFYSQITRYV 584
            ..|..:::.:|..||.:....||||.:|.|..:.......||:
Zfish   935 QICTIDVYMVMVKCWMIDENVRPTFKELASEFTRMARDPPRYL 977

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dnt	NP_001260567.1	WIF	46..182	CDD:128745
		PKc_like	310..580	CDD:304357	77/281 (27%)
		Pkinase_Tyr	317..573	CDD:285015	77/267 (29%)
erbb3b	NP_001014826.1	Recep_L_domain	54..164	CDD:279382
		Furin-like	176..325	CDD:279142
		FU	222..267	CDD:238021
		Recep_L_domain	348..471	CDD:279382
		GF_recep_IV	498..630	CDD:291509
		FU	499..>532	CDD:238021
		FU	546..592	CDD:214589
		TM_ErbB3	639..677	CDD:213056
		PTK_HER3	702..980	CDD:173656	79/288 (27%)
		Pkinase_Tyr	710..966	CDD:285015	77/267 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910