DRSC/TRiP Functional Genomics Resources

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Protein Alignment dnt and ROR1

DIOPT Version :10

Sequence 1:NP_477341.2 Gene:dnt / 35207 FlyBaseID:FBgn0024245 Length:584 Species:Drosophila melanogaster
Sequence 2:NP_005003.2 Gene:ROR1 / 4919 HGNCID:10256 Length:937 Species:Homo sapiens


Alignment Length:567 Identity:131/567 - (23%)
Similarity:215/567 - (37%) Gaps:143/567 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    52 NPVEVMRLLGVSAEVYYVREGHINNYALNFIVPV--PANVKDISFTWQSLAGRGLPYSINVVSSD 114
            ||:.:|||...:.|.....|.......:...:|:  |.|.....:....:..||   :::|..|.
Human   270 NPMILMRLKLPNCEDLPQPESPEAANCIRIGIPMADPINKNHKCYNSTGVDYRG---TVSVTKSG 331

  Fly   115 QEVLP---------------RPAINVSHS--------GEIPTTIQTWSIALKCSGLKAAEVDVTV 156
            ::..|               .|.:|..||        .|.|     |...|. ...|:...|:..
Human   332 RQCQPWNSQYPHTHTFTALRFPELNGGHSYCRNPGNQKEAP-----WCFTLD-ENFKSDLCDIPA 390

  Fly   157 SLEVVLNRSLNNVTHLVFRRKKICLMNDSAEDLSEDVDDPQLLETVMLPPTGLITLVVGVSVAMG 221
                                   |...||.|....::               |..||..|::.:.
Human   391 -----------------------CDSKDSKEKNKMEI---------------LYILVPSVAIPLA 417

  Fly   222 SVCLLLMIAYC-----VKGAANKRQHHQHGGQPMRTSSFQRLNTHPPCQSSMGSAAYMTPSIIAP 281
            ...|...|..|     ...|..:||.....||.:..|   .||.:.|                  
Human   418 IALLFFFICVCRNNQKSSSAPVQRQPKHVRGQNVEMS---MLNAYKP------------------ 461

  Fly   282 IHGSSLPRKVPVSVEQQHPEELHRRISELTVERCRVRLSSLLQEGTFGRVYRG-----TYNDTQD 341
               .|..:::|:|.                     ||....|.|..||::|:|     ..:..|.
Human   462 ---KSKAKELPLSA---------------------VRFMEELGECAFGKIYKGHLYLPGMDHAQL 502

  Fly   342 VLVKTVAQHASQMQVLLLLQEGMLLYGASHPGILSVLGVSIEDHTTPFVLYPALNNTRNLKQFLL 406
            |.:||:..:.:..|.....||..|:....||.|:.:||...::.  |..:.....|..:|.:||:
Human   503 VAIKTLKDYNNPQQWTEFQQEASLMAELHHPNIVCLLGAVTQEQ--PVCMLFEYINQGDLHEFLI 565

  Fly   407 ------DPACAR----TVTTI----QIVMMASQLSMALDHLHSHGVVHKDIATRNCVIDDQLRVK 457
                  |..|:.    ||.:.    ..:.:|.|::..:::|.||..||||:|.||.:|.:||.||
Human   566 MRSPHSDVGCSSDEDGTVKSSLDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILIGEQLHVK 630

  Fly   458 LSDSSLSRDLFPSDYNCLGDSENRPVKWMSLEALQHKQFSEASDSWAFGVLMWELCTSAKQPYAE 522
            :||..|||:::.:||..:......|::||..||:.:.:||..||.|:|||::||:.:...|||..
Human   631 ISDLGLSREIYSADYYRVQSKSLLPIRWMPPEAIMYGKFSSDSDIWSFGVVLWEIFSFGLQPYYG 695

  Fly   523 VDPFEMEHYLKDGYRLAQPFNCPDELFTIMAYCWALLPAERPTFAQL 569
            ....|:...::....|....:||..::::|..||..:|:.||.|..:
Human   696 FSNQEVIEMVRKRQLLPCSEDCPPRMYSLMTECWNEIPSRRPRFKDI 742

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dntNP_477341.2 WIF 46..182 CDD:128745 26/154 (17%)
Protein Kinases, catalytic domain 310..580 CDD:473864 83/279 (30%)
ROR1NP_005003.2 IG_like 66..148 CDD:214653
Ig strand B 75..79 CDD:409570
Ig strand C 88..92 CDD:409570
Ig strand E 114..118 CDD:409570
Ig strand F 128..133 CDD:409570
Ig strand G 141..144 CDD:409570
CRD_TK_ROR1 166..307 CDD:143576 8/36 (22%)
KR 311..393 CDD:214527 16/113 (14%)
PTKc_Ror1 467..749 CDD:270672 85/299 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 753..779
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 833..890
Blue background indicates that the domain is not in the aligned region.

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