Protein Alignment dnt and Ret

DIOPT Version :10

• Sequence 1: NP_477341.2
• Gene: dnt / 35207
• FlyBaseID: FBgn0024245
• Length: 584
• Species: Drosophila melanogaster
• Sequence 2: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Alignment Length: 483
• Identity: 121/483 - (25%)
• Similarity: 201/483 - (41%)
• Gaps: 73/483 - (15%)

  Fly   149 AAEVDVTVSLEVVLNRSLNNVTHLVFRRKKICLMNDSAEDLSEDVD-DPQLL-------ETVMLP 205
            |...|.|.:..:|...|.|.....::.....|:..|:.:.....:| :|::.       ||...|
  Fly   597 ACPQDCTPAGRIVGPHSSNENKRGIYSASGTCICEDNGKCSCAPLDEEPKMKKPRKRKNETEAEP 661

  Fly   206 PTGL-----------ITLVVGVSVAMGSVC-------------LLLMIAYCVKGAANKRQHHQHG 246
            ..|:           ..:::||....|..|             |.:::..|:..|..|....:.|
  Fly   662 LLGVRRGTPPNQPLQDPMLLGVLNVAGFECDRSCMFFVITCPLLFVLLLLCLLIAQRKMLQRRLG 726

  Fly   247 GQPMRTSSFQRLNTHPPCQSSMGSAAYMTPSIIAPIHGSSLPRKVPVSVEQQHPEELHRRISELT 311
            .|.|.|||.|.|.     :|..|..|.|      |:....  |......:.:.|.|
  Fly   727 KQSMTTSSKQALP-----ESGGGDFALM------PLQSGF--RFESGDAKWEFPRE--------- 769

  Fly   312 VERCRVRLSSLLQEGTFGRVYRGTYND------TQDVLVKTVAQHASQMQVLLLLQEGMLLYGAS 370
                :::|.::|.||.||:|.:|...:      ...|.||.:.:.::.::.:.||.|..||...|
  Fly   770 ----KLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQEVS 830

  Fly   371 HPGILSVLGVSIEDHTTPFVL-YPALNNTRNLKQFLLDPACA--------RTVTTIQIVMMASQL 426
            ||.::.:||..........:: |....:.|:..:......||        ..|....::..|.|:
  Fly   831 HPNVIKLLGACTSSEAPLLIIEYARYGSLRSYLRLSRKIECAGVDFADGVEPVNVKMVLTFAWQI 895

  Fly   427 SMALDHLHSHGVVHKDIATRNCVIDDQLRVKLSDSSLSRDLFPSDYNCLGDSENRPVKWMSLEAL 491
            ...:.:|....:||:|:|.||.::.|....|:||..|:||::..|.......:..|||||:.|:|
  Fly   896 CKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVPVKWMAPESL 960

  Fly   492 QHKQFSEASDSWAFGVLMWELCTSAKQPYAEVDPFEMEHYLKDGYRLAQPFNCPDELFTIMAYCW 556
            ....::..||.|:||||.|||.|....||..:.|..:...||.|||:.:|.||.:.:::|:..||
  Fly   961 ADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSEAVYSIVRTCW 1025

  Fly   557 ALLPAERPTFAQLQSCLSEFYSQITRYV 584
            |..|..||:|..|.|...:......:|:
  Fly  1026 ADEPNGRPSFKFLASEFEKLLGNNAKYI 1053

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dnt	NP_477341.2	WIF	46..182	CDD:128745	7/32 (22%)
		Protein Kinases, catalytic domain	310..580	CDD:473864	82/284 (29%)
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	82/278 (29%)