DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dnt and Nrk

DIOPT Version :9

Sequence 1:	NP_001260567.1	Gene:	dnt / 35207	FlyBaseID:	FBgn0024245	Length:	584	Species:	Drosophila melanogaster
Sequence 2:	NP_477255.1	Gene:	Nrk / 36445	FlyBaseID:	FBgn0020391	Length:	724	Species:	Drosophila melanogaster

Alignment Length:	426	Identity:	115/426 - (26%)
Similarity:	200/426 - (46%)	Gaps:	49/426 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   184 DSAEDLSEDVDDPQLLETVMLPPTGLITLVVGVS-VAMGSVCLLLMIAYCVKGAANKRQHHQHGG 247
            |..:..:.|::.|..:|....|  .:|.|:.|:. ||:.::.|::::.|       |...|:...
  Fly   299 DYVDPNAVDLNTPIKMEKFFTP--SMIFLLAGIGFVAIVTLHLMILLVY-------KLSKHKDYS 354

  Fly   248 QPMRTSSFQ-------------RLNTHPPCQSSMGS----AAYMTPSIIAPIHGSSLPRKVPVSV 295
            ||...::.:             .|||........|:    |.:.|....|.||.:.:......:|
  Fly   355 QPAGAATAECSVSMRGGGDCGGNLNTSRETLGGNGNTNTLAKWGTIRSTATIHSNCVALTTVTNV 419

  Fly   296 EQQHPEELHRRISELTVERCRVRLSSLLQEGTFGRVYR----GTYNDTQDVL--VKTVAQHASQM 354
            ......:.:.|:.:|...|..:.....|.:|.||||::    |...|.:|:|  ||.:...||..
  Fly   420 SDAKGTKPNARLEKLEYPRGDIVYVRSLGQGAFGRVFQARAPGLVPDQEDLLVAVKMLKDDASDQ 484

  Fly   355 QVLLLLQEGMLLYGASHPGILSVLGVSIEDHTTPFVLYPALNNTRNLKQFLLDPACARTVT---- 415
            ..:...:|..||....||.|:.:|||.....  |..|........:|.:||  .||:...|
  Fly   485 MQMDFEREACLLAEFDHPNIVRLLGVCALGR--PMCLLFEYMAPGDLSEFL--RACSPYATHQAP 545

  Fly   416 --------TIQIVMMASQLSMALDHLHSHGVVHKDIATRNCVIDDQLRVKLSDSSLSRDLFPSDY 472
                    .:.::.||:.::..:.:|.....||:|:|||||:|::.:.||::|..||..::..||
  Fly   546 TQDRLQLNELHLLQMAANIAAGMLYLSERKFVHRDLATRNCLINEHMAVKIADFGLSHKIYLQDY 610

  Fly   473 NCLGDSENRPVKWMSLEALQHKQFSEASDSWAFGVLMWELCTSAKQPYAEVDPFEMEHYLKDGYR 537
            ....:::..|::||.||::.:.:||..||.||:|:.:||:.:.|.|||..:...|:..|:|:|..
  Fly   611 YKGDENDFIPIRWMPLESILYNKFSLESDVWAYGICLWEVFSFALQPYFGLTHEEVIKYIKEGNV 675

  Fly   538 LAQPFNCPDELFTIMAYCWALLPAERPTFAQLQSCL 573
            |..|.|.|..::.:|..||...|:|||.||::..|:
  Fly   676 LGCPDNTPLSVYALMRRCWNRKPSERPGFAEINHCI 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dnt	NP_001260567.1	WIF	46..182	CDD:128745
		PKc_like	310..580	CDD:304357	88/282 (31%)
		Pkinase_Tyr	317..573	CDD:285015	85/273 (31%)
Nrk	NP_477255.1	CRD_FZ	67..212	CDD:295308
		KR	217..299	CDD:214527	115/426 (27%)
		PTKc_Musk	435..713	CDD:133181	87/281 (31%)
		Pkinase_Tyr	441..707	CDD:285015	85/269 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455365
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940