DRSC/TRiP Functional Genomics Resources

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Protein Alignment dnt and INSR

DIOPT Version :10

Sequence 1:NP_477341.2 Gene:dnt / 35207 FlyBaseID:FBgn0024245 Length:584 Species:Drosophila melanogaster
Sequence 2:NP_000199.2 Gene:INSR / 3643 HGNCID:6091 Length:1382 Species:Homo sapiens


Alignment Length:406 Identity:111/406 - (27%)
Similarity:189/406 - (46%) Gaps:76/406 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   189 LSEDVDDPQLLETVMLPPTGLITLVVGVSVAMGSVCLLLMIAYCVKGAANKRQHHQHGGQPMRTS 253
            :::.:|.|..:..:::.|   :..|...||.:||:.|.|          .|||            
Human   944 VTDYLDVPSNIAKIIIGP---LIFVFLFSVVIGSIYLFL----------RKRQ------------ 983

  Fly   254 SFQRLNTHPPCQSSMGSAAYMTPSIIAPIHGSSLPRKV------PVSVEQQHPEELHRRISELTV 312
                                 ....:.|::.||.|..:      |.||  ..|:|..       |
Human   984 ---------------------PDGPLGPLYASSNPEYLSASDVFPCSV--YVPDEWE-------V 1018

  Fly   313 ERCRVRLSSLLQEGTFGRVYRGTYND------TQDVLVKTVAQHASQMQVLLLLQEGMLLYGASH 371
            .|.::.|...|.:|:||.||.|...|      ...|.||||.:.||..:.:..|.|..::.|.:.
Human  1019 SREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTC 1083

  Fly   372 PGILSVLGVSIEDHTTPFVLYPALNNTRNLKQFL--LDPAC----ARTVTTIQ-IVMMASQLSMA 429
            ..::.:|||..:...|..|:  .|....:||.:|  |.|..    .|...|:| ::.||::::..
Human  1084 HHVVRLLGVVSKGQPTLVVM--ELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADG 1146

  Fly   430 LDHLHSHGVVHKDIATRNCVIDDQLRVKLSDSSLSRDLFPSDYNCLGDSENRPVKWMSLEALQHK 494
            :.:|::...||:|:|.|||::.....||:.|..::||::.:||...|.....||:||:.|:|:..
Human  1147 MAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDG 1211

  Fly   495 QFSEASDSWAFGVLMWELCTSAKQPYAEVDPFEMEHYLKDGYRLAQPFNCPDELFTIMAYCWALL 559
            .|:.:||.|:|||::||:.:.|:|||..:...::..::.||..|.||.|||:.:..:|..||...
Human  1212 VFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFN 1276

  Fly   560 PAERPTFAQLQSCLSE 575
            |..||||.::.:.|.:
Human  1277 PKMRPTFLEIVNLLKD 1292

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dntNP_477341.2 WIF 46..182 CDD:128745
Protein Kinases, catalytic domain 310..580 CDD:473864 89/279 (32%)
INSRNP_000199.2 Recep_L_domain 52..164 CDD:460032
Furin-like 179..337 CDD:395614
Recep_L_domain 359..472 CDD:460032
FN3 <582..>658 CDD:442628
FN3 622..>665 CDD:238020
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 686..708
Insulin-binding 733..741
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 746..766
FN3 867..944 CDD:238020 111/406 (27%)
Insulin_TMD 940..987 CDD:465543 13/88 (15%)
PTKc_InsR 1016..1303 CDD:133192 89/286 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1360..1382
PIK3R1-binding 1361..1364
Blue background indicates that the domain is not in the aligned region.

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