Protein Alignment dnt and IGF1R

DIOPT Version :10

• Sequence 1: NP_477341.2
• Gene: dnt / 35207
• FlyBaseID: FBgn0024245
• Length: 584
• Species: Drosophila melanogaster
• Sequence 2: XP_016877626.1
• Gene: IGF1R / 3480
• HGNCID: 5465
• Length: 1392
• Species: Homo sapiens
• Alignment Length: 723
• Identity: 159/723 - (21%)
• Similarity: 273/723 - (37%)
• Gaps: 215/723 - (29%)

  Fly    49 VFLNPVEVMRLLGVSAEVYYVREGHINNYALNFIVP-VPANVKDIS------------------- 93
            |.|..||...:.|..:|:.|:|        .|..|| :|.:|...|
Human   609 VTLTMVENDHIRGAKSEILYIR--------TNASVPSIPLDVLSASNSSSQLIVKWNPPSLPNGN 665

  Fly    94 -----FTWQSLAGRGLPYSINVVSSDQEVLPRPA---INVSHSGEIPTTIQTWSIALKCSGLKAA 150
                 ..||.....|..|..|..|.|:..:.:.|   |::....|.|.|.........|......
Human   666 LSYYIVRWQRQPQDGYLYRHNYCSKDKIPIRKYADGTIDIEEVTENPKTEVCGGEKGPCCACPKT 730

  Fly   151 EVDVTVSLEVVLNRSL--NNVTHLVF----RRKKICLM------------NDSAEDLSEDVDDPQ 197
            |.:.....|....|.:  |.:.:.:|    .||:..:|            |.:|.| :.::.||:
Human   731 EAEKQAEKEEAEYRKVFENFLHNSIFVPRPERKRRDVMQVANTTMSSRSRNTTAAD-TYNITDPE 794

  Fly   198 LLETVM-----------------LPPTGLITLVV--------------------------GVSVA 219
            .|||..                 |.|..|..:.:                          |....
Human   795 ELETEYPFFESRVDNKERTVISNLRPFTLYRIDIHSCNHEAEKLGCSASNFVFARTMPAEGADDI 859

  Fly   220 MGSVC---------------------LLLM--IAY---------CVKGAANKRQHHQHGGQPMRT 252
            .|.|.                     |:||  |.|         ||    :::::.::||
Human   860 PGPVTWEPRPENSIFLKWPEPENPNGLILMYEIKYGSQVEDQRECV----SRQEYRKYGG----- 915

  Fly   253 SSFQRLN-------------------THPP---CQSSMGSAAYMTPSIIAPIHGSSLPRKVPVSV 295
            :...|||                   |.|.   .|:..|...::...|..|:....:...:.:.:
Human   916 AKLNRLNPGNYTARIQATSLSGNGSWTDPVFFYVQAKTGYENFIHLIIALPVAVLLIVGGLVIML 980

  Fly   296 EQQHPEELHRRI----------------------SELTVERCRVRLSSLLQEGTFGRVY----RG 334
            ...|.:..:.|:                      .|..|.|.::.:|..|.:|:||.||    :|
Human   981 YVFHRKRNNSRLGNGVLYASVNPEYFSAADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKG 1045

  Fly   335 TYNDTQD--VLVKTVAQHASQMQVLLLLQEGMLL--YGASHPGILSVLGVSIEDHTTPFVLYPAL 395
            ...|..:  |.:|||.:.||..:.:..|.|..::  :...|  ::.:|||..:...|..::  .|
Human  1046 VVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHH--VVRLLGVVSQGQPTLVIM--EL 1106

  Fly   396 NNTRNLKQFLL--------DPACARTVTTIQIVMMASQLSMALDHLHSHGVVHKDIATRNCVIDD 452
            ....:||.:|.        :|..| ..:..:::.||.:::..:.:|:::..||:|:|.|||::.:
Human  1107 MTRGDLKSYLRSLRPEMENNPVLA-PPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAE 1170

  Fly   453 QLRVKLSDSSLSRDLFPSDYNCLGDSENRPVKWMSLEALQHKQFSEASDSWAFGVLMWELCTSAK 517
            ...||:.|..::||::.:||...|.....||:|||.|:|:...|:..||.|:|||::||:.|.|:
Human  1171 DFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAE 1235

  Fly   518 QPYAEVDPFEMEHYLKDGYRLAQPFNCPDELFTIMAYCWALLPAERPTFAQLQSCLSE------- 575
            |||..:...::..::.:|..|.:|.||||.||.:|..||...|..||:|.::.|.:.|
Human  1236 QPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFR 1300

  Fly   576 ----FYSQ 579
                :||:
Human  1301 EVSFYYSE 1308

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dnt	NP_477341.2	WIF	46..182	CDD:128745	34/166 (20%)
		Protein Kinases, catalytic domain	310..580	CDD:473864	89/297 (30%)
IGF1R	XP_016877626.1	Recep_L_domain	76..186	CDD:460032
		Furin-like	200..355	CDD:395614
		Recep_L_domain	377..492	CDD:460032
		FN3	519..631	CDD:238020	8/29 (28%)
		FN3	636..>680	CDD:238020	6/43 (14%)
		FN3	860..949	CDD:238020	16/97 (16%)
		PTKc_InsR_like	1017..1293	CDD:173625	86/280 (31%)