DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment dnt and fgfr1a

DIOPT Version :10

Sequence 1:NP_477341.2 Gene:dnt / 35207 FlyBaseID:FBgn0024245 Length:584 Species:Drosophila melanogaster
Sequence 2:NP_694494.2 Gene:fgfr1a / 30705 ZFINID:ZDB-GENE-980526-255 Length:810 Species:Danio rerio


Alignment Length:554 Identity:146/554 - (26%)
Similarity:238/554 - (42%) Gaps:94/554 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    70 REGHINN-YALNFIVPVPANVKDISFTWQSLAGRGLPYS-INVVSSDQEVL------PRP----- 121
            |.|.||: |.|:.:...|         .:.:...|||.: ..||.||.|..      |:|     
Zfish   224 RHGSINHTYQLDVVERSP---------HRPILQAGLPANRTAVVGSDVEFECKVFSDPQPHIQWL 279

  Fly   122 ---AINVSHSGE--IPTTIQTWSIALKCSGLKAAEVDVTVSLEVVLNRSLNNVTHLVFRRKKICL 181
               .:|.|..|.  :|     :..|||.:|:...:.::.| |: :.|.||.:.....      ||
Zfish   280 KHIEVNGSRYGPDGLP-----YVRALKTAGVNTTDKEMEV-LQ-IRNVSLEDAGEYT------CL 331

  Fly   182 MNDSAEDLSEDVDDPQLLETVMLPPTGL--------ITLVVG---VSVAMGSVCLLLMIAYCVKG 235
            ..:|   :........|.....:|||.|        :...||   :.|.:|:..|..|.:...|.
Zfish   332 AGNS---IGHSHHSAWLTVYKAVPPTQLPNQTYLEVLIYCVGFFLICVMVGTAVLAKMHSSAKKS 393

  Fly   236 AANKR--QHHQHGGQPMRTSSFQRLNTHPPCQSSMGSAAYMT-PSIIAPIHGSSLPRKVPVSVEQ 297
            ..|.:  .|......|:|    :::.......|||.|...:. ||.::   .|..|....|| |.
Zfish   394 DFNSQLAVHKLAKSIPLR----RQVTVSVDSSSSMHSGGMLVRPSRLS---SSGSPMLSGVS-EY 450

  Fly   298 QHPEELHRRISELTVERCRVRLSSLLQEGTFGRVY--------RGTYNDTQDVLVKTVAQHASQM 354
            :.|::     ....|:|.|:.|...|.||.||:|.        :...|....|.||.:...|::.
Zfish   451 ELPQD-----PRWEVQRDRLVLGKPLGEGCFGQVMMAEAMGMDKEKPNRITKVAVKMLKSDATEK 510

  Fly   355 QVLLLLQE-GMLLYGASHPGILSVLGVSIEDHTTPFVLYPALNNTRNLKQFLL------------ 406
            .:..|:.| .|:.....|..|:::||...:|  .|..:........||:::|.            
Zfish   511 DLSDLISEMEMMKIIGKHKNIINLLGACTQD--GPLYVIVEFAAKGNLREYLRVRRPPGMEYCYN 573

  Fly   407 -DPACARTVTTIQIVMMASQLSMALDHLHSHGVVHKDIATRNCVIDDQLRVKLSDSSLSRDLFPS 470
             |......::...:|..|.|::..:::|.|...:|:|:|.||.::.:...:|::|..|:||:...
Zfish   574 PDQVPVENMSIKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHI 638

  Fly   471 DYNCLGDSENRPVKWMSLEALQHKQFSEASDSWAFGVLMWELCTSAKQPYAEVDPFEMEHYLKDG 535
            ||.....:...|||||:.|||..:.::..||.|:||||:||:.|....||..|...|:...||:|
Zfish   639 DYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEG 703

  Fly   536 YRLAQPFNCPDELFTIMAYCWALLPAERPTFAQL 569
            :|:.:|..|..||:.:|..||..:|::||||.||
Zfish   704 HRMDRPSTCTHELYMMMRDCWHAVPSQRPTFKQL 737

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dntNP_477341.2 WIF 46..182 CDD:128745 31/129 (24%)
Protein Kinases, catalytic domain 310..580 CDD:473864 85/282 (30%)
fgfr1aNP_694494.2 Ig 28..116 CDD:472250
Ig strand B 49..53 CDD:409353
Ig strand C 61..65 CDD:409353
Ig strand E 82..86 CDD:409353
Ig strand F 96..101 CDD:409353
Ig strand G 109..112 CDD:409353
Ig 142..236 CDD:472250 6/11 (55%)
Ig strand B 163..167 CDD:409353
Ig strand C 176..180 CDD:409353
Ig strand E 202..206 CDD:409353
Ig strand F 216..221 CDD:409353
Ig strand G 229..232 CDD:409353 1/2 (50%)
Ig 244..347 CDD:472250 27/118 (23%)
Ig strand B 262..266 CDD:409353 1/3 (33%)
Ig strand C 275..279 CDD:409353 0/3 (0%)
Ig strand E 313..317 CDD:409353 2/5 (40%)
Ig strand F 327..332 CDD:409353 1/10 (10%)
Ig strand G 340..343 CDD:409353 0/2 (0%)
PTKc_FGFR1 451..752 CDD:270678 86/294 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 787..810
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.