Protein Alignment dnt and ephb3a

DIOPT Version :10

• Sequence 1: NP_477341.2
• Gene: dnt / 35207
• FlyBaseID: FBgn0024245
• Length: 584
• Species: Drosophila melanogaster
• Sequence 2: NP_571172.2
• Gene: ephb3a / 30313
• ZFINID: ZDB-GENE-990415-60
• Length: 925
• Species: Danio rerio
• Alignment Length: 597
• Identity: 152/597 - (25%)
• Similarity: 242/597 - (40%)
• Gaps: 111/597 - (18%)

  Fly     6 KC---GKSASTRNCTVKMSRKMWVLS--LLALAALQLHSGSEVAAHLNVFLNPVEVMRLLGVS-- 63
            ||   |.|.:..:..|::|.:...|:  ..|:..||.|:      |.:     .|:..:.|||
Zfish   361 KCLHDGGSCARCDDNVEVSPRRLGLAERQAAVRNLQAHT------HYS-----FEIQAVNGVSPK 414

  Fly    64 --AEVYYVREGHINNYALNFIVP----VPANVKDISFTWQSLAGRGLPYSINVVSSDQEVLPRPA 122
              :...|.......|.|....||    :.|....:|.:|..      |...|.|..|.|
Zfish   415 SPSSPQYTTVNITTNQAAPSAVPTVHLMRATAGTLSLSWLP------PEQPNGVILDYE------ 467

  Fly   123 INVSHSGE-IPTTIQTWSIALKCSGLKAAEV-DVTVSLEVV--LNRSLNNVTHLVFRRKKICLMN 183
            |.....|| ...|:.....:.|..||||..| .|.|....|  ..|..|.|
Zfish   468 IKYQERGESFSHTVTAQHTSAKVEGLKAGTVYSVQVRARTVAGYGRYSNPV-------------- 518

  Fly   184 DSAEDLSEDV-DDPQLLETVMLPPTGLITLVVGVSVAMGSVCLLLMIAYCVKGAANKRQHHQHGG 247
                |.|..: |||:.....:||      |:|| |.:.|.|.:|.||...|  ...:||  :.|.
Zfish   519 ----DFSTSLYDDPERSVQDLLP------LIVG-SASAGFVVILAMIVIAV--VCLRRQ--RTGS 568

  Fly   248 QPMRTSSFQRLNTHPPCQSSMGSAAYMTPSIIAPIHGSSLPRKVPVSVEQQHPEELHRRISELTV 312
            :...|...|:               |::|.:...|.        |.:.|..: |.:|....|:.:
Zfish   569 ELEYTEKLQQ---------------YVSPGVKVYID--------PFTYEDPN-EAVHEFAREIDI 609

  Fly   313 ERCRVRLSSLLQEGTFGRVYRGTYNDT----QDVLVKTVAQHASQMQVLLLLQEGMLLYGASHPG 373
            . | |::..::..|.||.|.||.....    ..|.:||:....::.|....|.|..::....||.
Zfish   610 S-C-VKIEEVIGAGEFGEVCRGRLKQAGRKETTVAIKTLKAGYTEHQRRDFLSEASIMGQFDHPN 672

  Fly   374 ILSVLGVSIEDHTTPFVLYPALNNTRNLKQFLLDPACARTVTTIQIVMMASQLSMALDHLHSHGV 438
            ::.:.||.  ..:.|.::.........|..||.......|||  |:|.|...::..:.:|.....
Zfish   673 VIHLEGVL--TRSCPVLIVTEFMENGALDSFLRLNDGRFTVT--QLVGMLRGIAAGMKYLSDMNY 733

  Fly   439 VHKDIATRNCVIDDQLRVKLSDSSLSRDL-----FPSDYNCLGDSENRPVKWMSLEALQHKQFSE 498
            ||:|:|.||.:::..|..|:||..|||.|     .|:..:.||.  ..|::|.:.||:..::|:.
Zfish   734 VHRDLAARNVLVNSNLVCKVSDFGLSRFLDDNSSDPTYTSSLGG--KIPIRWTAPEAIAFRKFTS 796

  Fly   499 ASDSWAFGVLMWELCTSAKQPYAEVDPFEMEHYLKDGYRLAQPFNCPDELFTIMAYCWALLPAER 563
            |||.|::|::|||:.:..::||.::...::.:.::..|||..|.:||..|..:|..||......|
Zfish   797 ASDVWSYGIVMWEVMSFGERPYWDMSNQDVMNAVEQDYRLPPPMDCPAVLHQLMLECWVKERNMR 861

  Fly   564 PTFAQLQSCLSE 575
            |.|.|:.|.|.:
Zfish   862 PRFGQIVSTLDK 873

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dnt	NP_477341.2	WIF	46..182	CDD:128745	34/147 (23%)
		Protein Kinases, catalytic domain	310..580	CDD:473864	77/275 (28%)
ephb3a	NP_571172.2	EphR_LBD_B3	21..193	CDD:198446
		FN3	<316..>523	CDD:442628	47/202 (23%)
		FN3	433..522	CDD:238020	27/118 (23%)
		EphA2_TM	539..608	CDD:464211	22/97 (23%)
		PTKc_EphR_B	607..875	CDD:173638	77/275 (28%)