DRSC/TRiP Functional Genomics Resources

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Protein Alignment dnt and EPHA10

DIOPT Version :10

Sequence 1:NP_477341.2 Gene:dnt / 35207 FlyBaseID:FBgn0024245 Length:584 Species:Drosophila melanogaster
Sequence 2:NP_001092909.1 Gene:EPHA10 / 284656 HGNCID:19987 Length:1008 Species:Homo sapiens


Alignment Length:631 Identity:142/631 - (22%)
Similarity:234/631 - (37%) Gaps:168/631 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 KCGKSASTRNCTVKMSRKMWVLSLLALAALQLHSGSEVAAHLNVFLNP-----VEVMRLLGVSAE 65
            :||:......|.....|         :|.|...:|....|...:.|.|     |.|..|.|||. 
Human   379 RCGREGPAGACEPCGPR---------VAFLPRQAGLRERAATLLHLRPGARYTVRVAALNGVSG- 433

  Fly    66 VYYVREGHINNYALNFIVPVPANVKDISFTWQSLA-GRGLPYSINVVSSDQEVLPRPAINVSHSG 129
                                ||.....::...::: |.|.|:..:.:..|: |.|: ::::|...
Human   434 --------------------PAAAAGTTYAQVTVSTGPGAPWEEDEIRRDR-VEPQ-SVSLSWRE 476

  Fly   130 EIPT-------------------TIQTWSIALKCSGLKAAEVDVTVSLEVVLNRSLNNVTHLVFR 175
            .||.                   :.||:|:      :|.....|||:       :|...|..||:
Human   477 PIPAGAPGANDTEYEIRYYEKGQSEQTYSM------VKTGAPTVTVT-------NLKPATRYVFQ 528

  Fly   176 RK-----------------KICLMNDSAEDLSEDVDDPQLLETVMLPPTGLITLVVGVSVAMGSV 223
            .:                 ::..:.::|.. |.| ..|.::.||         :.:...:.:|||
Human   529 IRAASPGPSWEAQSFNPSIEVQTLGEAASG-SRD-QSPAIVVTV---------VTISALLVLGSV 582

  Fly   224 CLLLMI--AYCVKGAANKRQHHQ-----HGGQPMRTSSFQRLNTHPPCQSSMGSAAYMTP----S 277
            ..:|.|  ..|..|......|.:     |...|.|.:                   ::.|    .
Human   583 MSVLAIWRRPCSYGKGGGDAHDEEELYFHFKVPTRRT-------------------FLDPQSCGD 628

  Fly   278 IIAPIHGSSLPRKVPVSVEQQHPEELHRRISELTVERCRVRLSSLLQEGTFGRVYRGTYN--DTQ 340
            ::..:|              ...:||..:  .:|:||.       |..|.||.:..|...  ..|
Human   629 LLQAVH--------------LFAKELDAK--SVTLERS-------LGGGRFGELCCGCLQLPGRQ 670

  Fly   341 DVLVKT--VAQHASQMQVLLLLQEGMLLYGASHPGILSVLGVSIEDHTTPFVLYPALNNTRNLKQ 403
            ::||..  :...||..|.|..|.|.:.|....|..|:.:.||.....|...|       |..:..
Human   671 ELLVAVHMLRDSASDSQRLGFLAEALTLGQFDHSHIVRLEGVVTRGSTLMIV-------TEYMSH 728

  Fly   404 FLLDPACAR---TVTTIQIVMMASQLSMALDHLHSHGVVHKDIATRNCVIDDQLRVKLSDSSLS- 464
            ..||....|   .:...|::.:...|:.|:.:|...|.||:.:|.|:.::...|..|:|..... 
Human   729 GALDGFLRRHEGQLVAGQLMGLLPGLASAMKYLSEMGYVHRGLAARHVLVSSDLVCKISGFGRGP 793

  Fly   465 RDLFPSDYNCLGDSENRPVKWMSLEALQHKQFSEASDSWAFGVLMWELCTSAKQPYAEVDPFEME 529
            ||...:.|..:  |...|..|.:.|.||...||.|||.|:||::|||:....::||.::...::.
Human   794 RDRSEAVYTTM--SGRSPALWAAPETLQFGHFSSASDVWSFGIIMWEVMAFGERPYWDMSGQDVI 856

  Fly   530 HYLKDGYRLAQPFNCPDELFTIMAYCWALLPAERPTFAQLQSCLSE 575
            ..::||:||..|.|||:.|..:|..||...|.|||.|:|:.|.||:
Human   857 KAVEDGFRLPPPRNCPNLLHRLMLDCWQKDPGERPRFSQIHSILSK 902

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dntNP_477341.2 WIF 46..182 CDD:128745 30/177 (17%)
Protein Kinases, catalytic domain 310..580 CDD:473864 83/274 (30%)
EPHA10NP_001092909.1 EphR_LBD_A10 35..210 CDD:198455
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 322..342
fn3 339..431 CDD:394996 13/60 (22%)
FN3 451..531 CDD:214495 19/94 (20%)
EphA2_TM 569..642 CDD:464211 17/114 (15%)
PTKc_EphR_A10 639..904 CDD:133195 85/282 (30%)
SAM_superfamily 929..998 CDD:472832
Blue background indicates that the domain is not in the aligned region.

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