DRSC/TRiP Functional Genomics Resources

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Protein Alignment dnt and Tyro3

DIOPT Version :10

Sequence 1:NP_477341.2 Gene:dnt / 35207 FlyBaseID:FBgn0024245 Length:584 Species:Drosophila melanogaster
Sequence 2:NP_058788.1 Gene:Tyro3 / 25232 RGDID:3923 Length:880 Species:Rattus norvegicus


Alignment Length:640 Identity:151/640 - (23%)
Similarity:254/640 - (39%) Gaps:152/640 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 STRNCTVKMSRKMWVLSLLALAALQLHSGSEVAAH-------LNVFLNPVE----VMRLLGVSAE 65
            |:.|.:|     .||.....||.  |||.:...||       |.|.: ||.    ::|.|..:  
  Rat   227 SSSNASV-----AWVPGADGLAL--LHSCTVQVAHAPGEWEALAVVV-PVPPFTCLLRNLAPA-- 281

  Fly    66 VYYVREGHINNYAL-----NFIVPVPANVKD-ISFTWQSLAGRGLPYSINVVSSD-------QEV 117
                     .||:|     |.:.|.|..  | :.|..:.||....|.:.:.:.:|       :||
  Rat   282 ---------TNYSLRVRCANALGPSPYG--DWVPFQTKGLAPARAPQNFHAIRTDSGLILEWEEV 335

  Fly   118 LPRPAINVSHSGEIPTTIQTWSIA----------LKCSGLKAAEVDVTVSLEVVLNRSLNNVTHL 172
            :|      ...||.|  :..:.::          |...|..|...|.....::||          
  Rat   336 IP------EDPGEGP--LGPYKLSWVQENGTQDELMVEGTTANLTDWDPQKDLVL---------- 382

  Fly   173 VFRRKKICLMNDSAEDLSEDVDDPQLLETVML---------PP---TGLITLVVGVSVAMGSVCL 225
                 ::|..|...       |.|.....|:.         ||   |..:.:|:||..|:.:...
  Rat   383 -----RVCASNAIG-------DGPWSQPLVVSSHDHAGRQGPPHSRTSWVPVVLGVLTALITAAA 435

  Fly   226 LLMIAYCVKGAANKRQHHQHGGQPMRTSSFQRLNTHPPCQSSMGSAAYMTPSIIAPIH---GSSL 287
            |.:|      ...||:.....||     :|..:       .:.|..|         :|   ..|.
  Rat   436 LALI------LLRKRRKETRFGQ-----AFDSV-------MARGEPA---------VHFRAARSF 473

  Fly   288 PRKVPVSVEQQ-----HPEELHRRISELTVERCRVRLSSLLQEGTFGRVYRGTYNDTQDVLVKTV 347
            .|:.|..:|..     ..:||..::.::.:...:..|..:|.:|.||.|............||..
  Rat   474 NRERPERIEATLDSLGISDELKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVA 538

  Fly   348 -----AQHASQMQVLLLLQEGMLLYGASHPGILSVLGVSIEDHT-----TPFVLYPALNNTRNLK 402
                 |...:...:...|:|...:....||.:..::|||:....     .|.|:.|.:.: .:|.
  Rat   539 VKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKH-GDLH 602

  Fly   403 QFLL------DPACARTVTTIQIVMMASQLSMALDHLHSHGVVHKDIATRNCVIDDQLRVKLSDS 461
            .|||      :|......|.::.::   .::..:::|.|...:|:|:|.|||::.:.:.|.::|.
  Rat   603 AFLLASRIGENPFNLPLQTLVRFMV---DIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADF 664

  Fly   462 SLSRDLFPSDYNCLGDSENRPVKWMSLEALQHKQFSEASDSWAFGVLMWELCTSAKQPYAEVDPF 526
            .|||.::..||...|.:...||||::||:|....::..||.|||||.|||:.|..:.|||.::..
  Rat   665 GLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVHSDVWAFGVTMWEIMTRGQTPYAGIENA 729

  Fly   527 EMEHYLKDGYRLAQPFNCPDELFTIMAYCWALLPAERPTFAQLQSCLSEFYSQIT 581
            |:.:||..|.||.||..|.:|::.:|..||:..|.:||:|..|:..|......::
  Rat   730 EIYNYLISGNRLKQPPECMEEVYDLMYQCWSADPKQRPSFTCLRMELENILGHLS 784

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dntNP_477341.2 WIF 46..182 CDD:128745 32/169 (19%)
Protein Kinases, catalytic domain 310..580 CDD:473864 81/285 (28%)
Tyro3NP_058788.1 Ig 40..126 CDD:472250
Ig strand B 50..54 CDD:409553
Ig strand C 63..67 CDD:409553
Ig strand E 90..94 CDD:409553
Ig strand F 104..109 CDD:409553
Ig strand G 118..121 CDD:409553
IgI_2_Axl_Tyro3_like 130..209 CDD:409407
Ig strand A 130..133 CDD:409407
Ig strand A' 136..140 CDD:409407
Ig strand B 144..153 CDD:409407
Ig strand C 158..165 CDD:409407
Ig strand C' 167..170 CDD:409407
Ig strand E 174..185 CDD:409407
Ig strand F 188..197 CDD:409407
Ig strand G 201..209 CDD:409407
FN3 215..307 CDD:238020 26/100 (26%)
fn3 315..396 CDD:394996 18/110 (16%)
PTKc_Tyro3 498..781 CDD:270659 81/286 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 804..827
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 842..864
Blue background indicates that the domain is not in the aligned region.

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