Protein Alignment dnt and Fgfr2

DIOPT Version :10

• Sequence 1: NP_477341.2
• Gene: dnt / 35207
• FlyBaseID: FBgn0024245
• Length: 584
• Species: Drosophila melanogaster
• Sequence 2: NP_036844.1
• Gene: Fgfr2 / 25022
• RGDID: 2611
• Length: 841
• Species: Rattus norvegicus
• Alignment Length: 671
• Identity: 156/671 - (23%)
• Similarity: 270/671 - (40%)
• Gaps: 131/671 - (19%)

  Fly     3 SVNKCGKSASTRNCTVKMSRKMWVLSLLALAALQLHSGSEVAAHLNVFLNPVEVMRLLGVSAEV- 66
            |.|:..:.|.....|.||.:::..:........:..:|.          ||...||.|....|.
  Rat   164 SENRSNQRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGG----------NPTPTMRWLKNGKEFK 218

  Fly    67 -------YYVREGHINNYALNFIVP---------VPANVKDISFTW----------QSLAGRGLP 105
                   |.||..|. :..:..:||         |......|:.|:          :.:...|||
  Rat   219 QEHRIGGYKVRNQHW-SLIMESVVPSDKGNYTCLVENEYGSINHTYHLDVVERSPHRPILQAGLP 282

  Fly   106 YSIN-VVSSDQEVL------PRPAI----NVSHSGE------IPTTIQTWSIALKCSGLKAAEVD 153
            .:.: ||..|.|.:      .:|.|    :|..:|.      :|     :...||.||:.::..:
  Rat   283 ANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLP-----YLKVLKHSGINSSNAE 342

  Fly   154 VTVSLEVVLNRSLNNVTHLVFRRKKICLMNDSAEDLSEDV--------DDPQLLETVMLPPTGLI 210
            |.         :|.|||.: ...:.||.:::.....::..        ..|...:.:...|..|.
  Rat   343 VL---------ALFNVTEM-DAGEYICKVSNYIGQANQSAWLTVLPKQQAPVREKEITASPDYLE 397

  Fly   211 TLVVGVSVAMGSVCLLLMIAYCVKGAANKRQHHQHGGQP------MRTSSFQRLNTHPPCQSSMG 269
            ..:..:.|.: ..|:::.:.:|......|:.  ....||      .|....:::.......|||.
  Rat   398 IAIYCIGVFL-IACMVVTVIFCRMKTTTKKP--DFSSQPAVHKLTKRIPLRRQVTVSAESSSSMN 459

  Fly   270 SAAYMTPSIIAPIHGSS---LPRKVPVSVEQQHPEELHRRISELTVERCRVRLSSLLQEGTFGRV 331
            |   .||.:......||   .|....|| |.:.||:     .:....|.::.|...|.||.||:|
  Rat   460 S---NTPLVRITTRLSSTADTPMLAGVS-EYELPED-----PKWEFPRDKLTLGKPLGEGCFGQV 515

  Fly   332 Y--------RGTYNDTQDVLVKTVAQHASQMQVLLLLQE-GMLLYGASHPGILSVLGVSIEDHTT 387
            .        :....:...|.||.:...|::..:..|:.| .|:.....|..|:::||...:|  .
  Rat   516 VMAEAVGIDKDRPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQD--G 578

  Fly   388 PFVLYPALNNTRNLKQFL-------------LDPACARTVTTIQIVMMASQLSMALDHLHSHGVV 439
            |..:.....:..||:::|             ::......:|...:|....||:..:::|.|...:
  Rat   579 PLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCI 643

  Fly   440 HKDIATRNCVIDDQLRVKLSDSSLSRDLFPSDYNCLGDSENRPVKWMSLEALQHKQFSEASDSWA 504
            |:|:|.||.::.:...:|::|..|:||:...||.....:...|||||:.|||..:.::..||.|:
  Rat   644 HRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWS 708

  Fly   505 FGVLMWELCTSAKQPYAEVDPFEMEHYLKDGYRLAQPFNCPDELFTIMAYCWALLPAERPTFAQL 569
            |||||||:.|....||..:...|:...||:|:|:.:|.||.:||:.:|..||..:|::||||.||
  Rat   709 FGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPTNCTNELYMMMRDCWHAVPSQRPTFKQL 773

  Fly   570 QSCL--------SEFYSQITR 582
            ...|        :|.|..:|:
  Rat   774 VEDLDRILTLTTNEEYLDLTQ 794

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dnt	NP_477341.2	WIF	46..182	CDD:128745	38/179 (21%)
		Protein Kinases, catalytic domain	310..580	CDD:473864	86/299 (29%)
Fgfr2	NP_036844.1	Ig	50..143	CDD:472250
		Ig strand B	77..81	CDD:409362
		Ig strand C	88..92	CDD:409362
		Ig strand E	109..113	CDD:409362
		Ig strand F	123..128	CDD:409362
		Ig strand G	136..139	CDD:409362
		IgI_2_FGFR	173..267	CDD:409443	19/104 (18%)
		Ig strand A	173..176	CDD:409443	0/2 (0%)
		Ig strand A'	184..189	CDD:409443	0/4 (0%)
		Ig strand B	193..201	CDD:409443	0/7 (0%)
		Ig strand C	207..212	CDD:409443	2/4 (50%)
		Ig strand C'	215..217	CDD:409443	0/1 (0%)
		Ig strand D	226..229	CDD:409443	1/2 (50%)
		Ig strand E	233..238	CDD:409443	0/5 (0%)
		Ig strand F	247..254	CDD:409443	1/6 (17%)
		Ig strand G	257..267	CDD:409443	2/9 (22%)
		Ig	275..377	CDD:472250	23/116 (20%)
		Ig strand B	293..297	CDD:409353	1/3 (33%)
		Ig strand C	306..310	CDD:409353	1/3 (33%)
		Ig strand E	342..346	CDD:409353	1/12 (8%)
		Ig strand F	356..361	CDD:409353	2/4 (50%)
		Ig strand G	369..372	CDD:409353	0/2 (0%)
		PTKc_FGFR2	476..788	CDD:270679	90/319 (28%)