DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment dnt and Erbb2

DIOPT Version :9

Sequence 1:NP_001260567.1 Gene:dnt / 35207 FlyBaseID:FBgn0024245 Length:584 Species:Drosophila melanogaster
Sequence 2:NP_058699.2 Gene:Erbb2 / 24337 RGDID:2561 Length:1259 Species:Rattus norvegicus


Alignment Length:413 Identity:100/413 - (24%)
Similarity:163/413 - (39%) Gaps:108/413 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   205 PPTGLITLVVGVSVAMGSVCLLLMIAYCVKGAANKRQHHQHGGQPMRTSSFQRLNTHPPCQSSMG 269
            |.|.:|..||||        ||.:|...|.|...||:.     |.:|..:.:||           
  Rat   654 PVTFIIATVVGV--------LLFLILVVVVGILIKRRR-----QKIRKYTMRRL----------- 694

  Fly   270 SAAYMTPSIIAPIHGSSLPRKVPVSVEQQHPEELHRRISELTVERCRVRLSSLLQEGTFGRVYRG 334
               .....::.|:..|.           ..|.:...||    ::...:|...:|..|.||.||:|
  Rat   695 ---LQETELVEPLTPSG-----------AMPNQAQMRI----LKETELRKVKVLGSGAFGTVYKG 741

  Fly   335 TY-----NDTQDVLVKTVAQHASQMQVLLLLQEGMLLYGASHPGILSVLGVSIEDHTTPFVLYPA 394
            .:     |....|.:|.:.::.|......:|.|..::.|...|.:..:||:.:            
  Rat   742 IWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICL------------ 794

  Fly   395 LNNTRNLKQFLLDPACARTVTTIQIVMMASQLSMALDHLHSH----------------------- 436
                               .:|:|:|.........|||:..|                       
  Rat   795 -------------------TSTVQLVTQLMPYGCLLDHVREHRGRLGSQDLLNWCVQIAKGMSYL 840

  Fly   437 ---GVVHKDIATRNCVIDDQLRVKLSDSSLSR--DLFPSDYNCLGDSENRPVKWMSLEALQHKQF 496
               .:||:|:|.||.::.....||::|..|:|  |:..::|:  .|....|:|||:||::..::|
  Rat   841 EDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYH--ADGGKVPIKWMALESILRRRF 903

  Fly   497 SEASDSWAFGVLMWELCTSAKQPYAEVDPFEMEHYLKDGYRLAQPFNCPDELFTIMAYCWALLPA 561
            :..||.|::||.:|||.|...:||..:...|:...|:.|.||.||..|..:::.||..||.:...
  Rat   904 THQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSE 968

  Fly   562 ERPTFAQLQSCLSEFYSQITRYV 584
            .||.|.:|.|..|.......|:|
  Rat   969 CRPRFRELVSEFSRMARDPQRFV 991

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dntNP_001260567.1 WIF 46..182 CDD:128745
PKc_like 310..580 CDD:304357 75/302 (25%)
Pkinase_Tyr 317..573 CDD:285015 74/288 (26%)
Erbb2NP_058699.2 Recep_L_domain 55..177 CDD:279382
Furin-like 193..342 CDD:279142
FU 239..284 CDD:238021
Recep_L_domain 370..490 CDD:279382
GF_recep_IV 514..647 CDD:291509
FU 515..565 CDD:238021
FU 561..607 CDD:214589
TM_ErbB2 645..688 CDD:213055 15/46 (33%)
PTKc_HER2 716..994 CDD:270684 79/313 (25%)
Pkinase_Tyr 724..980 CDD:285015 74/288 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1025
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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