DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment dnt and Egfr

DIOPT Version :10

Sequence 1:NP_477341.2 Gene:dnt / 35207 FlyBaseID:FBgn0024245 Length:584 Species:Drosophila melanogaster
Sequence 2:NP_113695.2 Gene:Egfr / 24329 RGDID:2543 Length:1209 Species:Rattus norvegicus


Alignment Length:505 Identity:114/505 - (22%)
Similarity:206/505 - (40%) Gaps:111/505 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   104 LPYSINVVSSDQEVLPRPAINVSHSGEIPTTIQTWSIALKC-SGLKAAEVDVTVSLEVVLNRSL- 166
            ||.::|:..:.:.  |...|..:|..:.|..::|      | ||:...            |.:| 
  Rat   563 LPQTMNITCTGRG--PDNCIKCAHYVDGPHCVKT------CPSGIMGE------------NNTLV 607

  Fly   167 ------NNVTHLVFRRKKICLMNDSAEDLSEDVDDPQLLETVMLPPTGLITLVVGVSVAMGSVCL 225
                  |||.||       |..|.:.......:...|..|...:|     ::..|:   :|.:..
  Rat   608 WKFADANNVCHL-------CHANCTYGCAGPGLKGCQQPEGPKIP-----SIATGI---VGGLLF 657

  Fly   226 LLMIAYCVKGAANKRQHHQHGGQPMRTSSFQRLNTHPPCQSSMGSAAYMTPSIIAPIHGSSLPRK 290
            ::::|..: |...:|:|      .:|..:.:||              .....::.|:..|.    
  Rat   658 IVVVALGI-GLFMRRRH------IVRKRTLRRL--------------LQERELVEPLTPSG---- 697

  Fly   291 VPVSVEQQHPEELHRRI-SELTVERCRVRLSSLLQEGTFGRVYRGTYNDTQD-----VLVKTVAQ 349
                   :.|.:.|.|| .|...::.:|     |..|.||.||:|.:....:     |.:|.:.:
  Rat   698 -------EAPNQAHLRILKETEFKKIKV-----LGSGAFGTVYKGLWIPEGEKVKIPVAIKELRE 750

  Fly   350 HASQMQVLLLLQEGMLLYGASHPGILSVLGVSIEDHTTPFV--LYP---ALNNTRNLK-----QF 404
            ..|......:|.|..::....:|.:..:||:.:.. |...:  |.|   .|:..|..|     |:
  Rat   751 ATSPKANKEILDEAYVMASVDNPHVCRLLGICLTS-TVQLITQLMPYGCLLDYVREHKDNIGSQY 814

  Fly   405 LLDPACARTVTTIQIVMMASQLSMALDHLHSHGVVHKDIATRNCVIDDQLRVKLSDSSLSRDLFP 469
            ||:              ...|::..:::|....:||:|:|.||.::.....||::|..|::.|..
  Rat   815 LLN--------------WCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGA 865

  Fly   470 SDYNCLGDSENRPVKWMSLEALQHKQFSEASDSWAFGVLMWELCTSAKQPYAEVDPFEMEHYLKD 534
            .:.....:....|:|||:||::.|:.::..||.|::||.:|||.|...:||..:...|:...|:.
  Rat   866 EEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEK 930

  Fly   535 GYRLAQPFNCPDELFTIMAYCWALLPAERPTFAQLQSCLSEFYSQITRYV 584
            |.||.||..|..:::.||..||.:....||.|.:|....|:......||:
  Rat   931 GERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELILEFSKMARDPQRYL 980

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dntNP_477341.2 WIF 46..182 CDD:128745 19/85 (22%)
Protein Kinases, catalytic domain 310..580 CDD:473864 73/284 (26%)
EgfrNP_113695.2 Recep_L_domain 57..168 CDD:460032
Furin-like 187..335 CDD:395614
Recep_L_domain 362..481 CDD:460032
GF_recep_IV 505..637 CDD:464344 20/100 (20%)
TM_ErbB1 634..678 CDD:213054 10/58 (17%)
PTKc_EGFR 705..1017 CDD:270683 78/296 (26%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.