Protein Alignment dnt and FGFR3

DIOPT Version :10

• Sequence 1: NP_477341.2
• Gene: dnt / 35207
• FlyBaseID: FBgn0024245
• Length: 584
• Species: Drosophila melanogaster
• Sequence 2: XP_006713931.1
• Gene: FGFR3 / 2261
• HGNCID: 3690
• Length: 811
• Species: Homo sapiens
• Alignment Length: 527
• Identity: 140/527 - (26%)
• Similarity: 223/527 - (42%)
• Gaps: 79/527 - (14%)

  Fly    85 VPANVKDISFTWQSLAGRGLPYSINVVSSDQ---EVLPRPAINVSHSGEIPTTIQTWSIALKCSG 146
            :|||       ..::.|..:.:...|.|..|   :.|....:|.|..|...|...|   .||...
Human   259 LPAN-------QTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVT---VLKSWI 313

  Fly   147 LKAAEVDVTVSLEVVLNRS----LNNVTHLVFRRKKICLMNDSAEDLSEDVDDPQLLETVMLPPT 207
            .::.|.||.:.|..|..|.    |...|:.:...:|...::         |..|:..|..::...
Human   314 SESVEADVRLRLANVSERDGGEYLCRATNFIGVAEKAFWLS---------VHGPRAAEEELVEAD 369

  Fly   208 GLITLVVGV-SVAMGSVCLLLMIAYCV---------KGAANKRQHHQHGGQPMRTSSFQRLNTHP 262
            ...::..|: |..:|....:|::|...         ||..:...|        :.|.|.......
Human   370 EAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVH--------KISRFPLKRQVT 426

  Fly   263 PCQSSMGSAAYMTPSI-IAPIHGSSLPRKVPVSVEQQHPEELHRRISELTVERCRVRLSSLLQEG 326
            ....|..|.:..||.: ||.:.....|....|| |.:.|.:....:|     |.|:.|...|.||
Human   427 VSLESNASMSSNTPLVRIARLSSGEGPTLANVS-ELELPADPKWELS-----RARLTLGKPLGEG 485

  Fly   327 TFGRVYR----GTYNDTQ----DVLVKTVAQHASQMQVLLLLQE-GMLLYGASHPGILSVLGVSI 382
            .||:|..    |...|..    .|.||.:...|:...:..|:.| .|:.....|..|:::||...
Human   486 CFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACT 550

  Fly   383 EDHTTPFVL--YPALNNTRNLKQFL-------LD---PAC---ARTVTTIQIVMMASQLSMALDH 432
            :.... :||  |.|..   ||::||       ||   ..|   ...:|...:|..|.|::..:::
Human   551 QGGPL-YVLVEYAAKG---NLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEY 611

  Fly   433 LHSHGVVHKDIATRNCVIDDQLRVKLSDSSLSRDLFPSDYNCLGDSENRPVKWMSLEALQHKQFS 497
            |.|...:|:|:|.||.::.:...:|::|..|:||:...||.....:...|||||:.|||..:.::
Human   612 LASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYT 676

  Fly   498 EASDSWAFGVLMWELCTSAKQPYAEVDPFEMEHYLKDGYRLAQPFNCPDELFTIMAYCWALLPAE 562
            ..||.|:||||:||:.|....||..:...|:...||:|:|:.:|.||..:|:.||..||...|::
Human   677 HQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQ 741

  Fly   563 RPTFAQL 569
            ||||.||
Human   742 RPTFKQL 748

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dnt	NP_477341.2	WIF	46..182	CDD:128745	24/103 (23%)
		Protein Kinases, catalytic domain	310..580	CDD:473864	91/284 (32%)
FGFR3	XP_006713931.1	Ig	37..109	CDD:472250
		Ig strand B	57..61	CDD:409362
		Ig strand C	69..75	CDD:409362
		Ig strand E	92..96	CDD:409362
		IgI_2_FGFR	151..245	CDD:409443
		Ig strand A	151..154	CDD:409443
		Ig strand A'	162..167	CDD:409443
		Ig strand B	171..179	CDD:409443
		Ig strand C	185..190	CDD:409443
		Ig strand C'	193..195	CDD:409443
		Ig strand D	204..207	CDD:409443
		Ig strand E	211..216	CDD:409443
		Ig strand F	225..232	CDD:409443
		Ig strand G	235..245	CDD:409443
		IgI_3_FGFR	253..354	CDD:409363	24/104 (23%)
		Ig strand A	253..256	CDD:409363
		Ig strand A'	260..264	CDD:409363	3/10 (30%)
		Ig strand B	272..279	CDD:409363	1/6 (17%)
		Ig strand C	283..290	CDD:409363	1/6 (17%)
		Ig strand D	305..310	CDD:409363	1/7 (14%)
		Ig strand E	321..326	CDD:409363	1/4 (25%)
		Ig strand F	334..342	CDD:409363	1/7 (14%)
		Ig strand G	345..353	CDD:409363	1/7 (14%)
		Protein Kinases, catalytic domain	463..797	CDD:473864	93/295 (32%)