DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment dnt and Tie1

DIOPT Version :10

Sequence 1:NP_477341.2 Gene:dnt / 35207 FlyBaseID:FBgn0024245 Length:584 Species:Drosophila melanogaster
Sequence 2:NP_035717.2 Gene:Tie1 / 21846 MGIID:99906 Length:1134 Species:Mus musculus


Alignment Length:637 Identity:152/637 - (23%)
Similarity:250/637 - (39%) Gaps:157/637 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 RKMWVLSLLALAA----LQLHSGSE-VAAHLNVFLNPVEVMRLLGVSAEVYYVREGHINNYALNF 81
            |..|.|..:.|:.    |:|..|:. .....|:.........|.|::...:|..:  :..|....
Mouse   561 RVSWSLPSVPLSGDGFLLRLWDGARGQERRENISFPQARTALLTGLTPGTHYQLD--VRLYHCTL 623

  Fly    82 IVPV--PANV--------------------KDISFTWQSLAGRGLPYSINVVSSDQEVLPRPAIN 124
            :.|.  ||:|                    .:|...||.......|.|..:|.          |.
Mouse   624 LGPASPPAHVHLPPSGPPAPRHLHAQALSDSEIQLMWQHPEAPSGPISKYIVE----------IQ 678

  Fly   125 VSHSGEIPTTIQTWSIALKCSGLKAAEVDVTVSLEVVLNRSLNNVTHLVFR-RKKICLMNDSAED 188
            |:.....|    .|           .:||......::: |.||..|..:|| |..:..:.|.:..
Mouse   679 VAGGSGDP----QW-----------MDVDRPEETSIIV-RGLNASTRYLFRVRASVQGLGDWSNT 727

  Fly   189 LSE-----------DVDDPQLLETVMLPPTGLITLVVGVSVAMGSVCLLLMIA----YCVKGAAN 238
            :.|           .|.:.:..|..:  ...|:..|||   ::.:.||.::.|    .|::.:..
Mouse   728 VEEATLGNGLQSEGPVRESRAAEEGL--DQQLVLAVVG---SVSATCLTILAALLALVCIRRSCL 787

  Fly   239 KRQHHQHGGQPMRTSSFQRLNTHPPCQSSMGSAAYMTPSIIAPIHGS-SLPRKVPVSVEQQHPEE 302
            .|:         ||.::         ||..|.     .:|:....|: :|.|:     .:..||.
Mouse   788 HRR---------RTFTY---------QSGSGE-----ETILQFSSGTLTLTRR-----PKPQPEP 824

  Fly   303 LHRRISE---LTVERCRVRLSSLLQEGTFGRVYRGTYND---TQDVLVKTVAQHAS--------- 352
            |...:.|   :|.|       .|:.||.||:|.|.....   ..:..:|.:.::||         
Mouse   825 LSYPVLEWEDITFE-------DLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHRDFAG 882

  Fly   353 QMQVLLLLQEGMLLYGASHPGILSVLGVSIEDHTTPFVLYPALNNT--RNLKQFL-------LDP 408
            :::||..|        ..||.|:::|| :.|:..   .||.|:...  .||..||       .||
Mouse   883 ELEVLCKL--------GHHPNIINLLG-ACENRG---YLYIAIEYAPYGNLLDFLRKSRVLETDP 935

  Fly   409 ACAR------TVTTIQIVMMASQLSMALDHLHSHGVVHKDIATRNCVIDDQLRVKLSDSSLSRDL 467
            |.||      |:::.|::..||..:..:.:|.....:|:|:|.||.::.:.|..|::|..|||..
Mouse   936 AFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGE 1000

  Fly   468 FPSDYNCLGDSENRPVKWMSLEALQHKQFSEASDSWAFGVLMWELCTSAKQPYAEVDPFEMEHYL 532
            .......:|   ..||:||::|:|.:..::..||.|:||||:||:.:....||..:...|:...|
Mouse  1001 EVYVKKTMG---RLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKL 1062

  Fly   533 KDGYRLAQPFNCPDELFTIMAYCWALLPAERPTFAQLQSCLSEFYSQITRYV 584
            ..|||:.||.||.||::.:|..||...|.|||.|||:...|.........||
Mouse  1063 PQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGRMLEARKAYV 1114

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dntNP_477341.2 WIF 46..182 CDD:128745 28/158 (18%)
Protein Kinases, catalytic domain 310..580 CDD:473864 89/296 (30%)
Tie1NP_035717.2 ig 127..208 CDD:395002
Furin-like 220..336 CDD:395614
EGF_Lam 225..263 CDD:238012
Ig 348..439 CDD:472250
Ig strand B 366..370 CDD:409353
Ig strand C 382..386 CDD:409353
Ig strand E 407..411 CDD:409353
Ig strand F 421..426 CDD:409353
Ig strand G 434..437 CDD:409353
fn3 447..518 CDD:394996
fn3 546..628 CDD:394996 13/68 (19%)
fn3 641..725 CDD:394996 20/109 (18%)
PTKc_Tie1 832..1128 CDD:270671 91/305 (30%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.