DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dnt and ERBB4

DIOPT Version :9

Sequence 1:	NP_001260567.1	Gene:	dnt / 35207	FlyBaseID:	FBgn0024245	Length:	584	Species:	Drosophila melanogaster
Sequence 2:	XP_016859066.1	Gene:	ERBB4 / 2066	HGNCID:	3432	Length:	1349	Species:	Homo sapiens

Alignment Length:	310	Identity:	81/310 - (26%)
Similarity:	141/310 - (45%)	Gaps:	38/310 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   292 PVSVEQQHPEELHRRI-SELTVERCRVRLSSLLQEGTFGRVYRGTYNDTQD-----VLVKTVAQH 350
            |::.....|.:...|| .|..::|.:|     |..|.||.||:|.:....:     |.:|.:.:.
Human   738 PLTPSGTAPNQAQLRILKETELKRVKV-----LGSGAFGTVYKGIWVPEGETVKIPVAIKILNET 797

  Fly   351 ASQMQVLLLLQEGMLLYGASHPGILSVLGVSIEDHTTPFVLYPALNNTRNLKQFLLDPAC----- 410
            ......:..:.|.:::....||.::.:|||             .|:.|..|...|:...|
Human   798 TGPKANVEFMDEALIMASMDHPHLVRLLGV-------------CLSPTIQLVTQLMPHGCLLEYV 849

  Fly   411 ---ARTVTTIQIVMMASQLSMALDHLHSHGVVHKDIATRNCVIDDQLRVKLSDSSLSRDLFPSD- 471
               ...:.:..::....|::..:.:|....:||:|:|.||.::.....||::|..|:| |...|
Human   850 HEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLAR-LLEGDE 913

  Fly   472 --YNCLGDSENRPVKWMSLEALQHKQFSEASDSWAFGVLMWELCTSAKQPYAEVDPFEMEHYLKD 534
              ||  .|....|:|||:||.:.:::|:..||.|::||.:|||.|...:||..:...|:...|:.
Human   914 KEYN--ADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEK 976

  Fly   535 GYRLAQPFNCPDELFTIMAYCWALLPAERPTFAQLQSCLSEFYSQITRYV 584
            |.||.||..|..:::.:|..||.:....||.|.:|.:..|.......||:
Human   977 GERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYL 1026

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dnt	NP_001260567.1	WIF	46..182	CDD:128745
		PKc_like	310..580	CDD:304357	74/285 (26%)
		Pkinase_Tyr	317..573	CDD:285015	72/271 (27%)
ERBB4	XP_016859066.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810