DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dnt and ERBB2

DIOPT Version :9

Sequence 1:	NP_001260567.1	Gene:	dnt / 35207	FlyBaseID:	FBgn0024245	Length:	584	Species:	Drosophila melanogaster
Sequence 2:	XP_024306409.1	Gene:	ERBB2 / 2064	HGNCID:	3430	Length:	1301	Species:	Homo sapiens

Alignment Length:	410	Identity:	106/410 - (25%)
Similarity:	175/410 - (42%)	Gaps:	75/410 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   192 DVDDPQL-LETVMLPPTGLITLVVGVSVAMGSVCLLLMIAYCVKGAANKRQHHQHGGQPMRTSSF 255
            |:||... .|....|.|.:|:.|||:        ||:::...|.|...||:.     |.:|..:.
Human   682 DLDDKGCPAEQRASPLTSIISAVVGI--------LLVVVLGVVFGILIKRRQ-----QKIRKYTM 733

  Fly   256 QRLNTHPPCQSSMGSAAYMTPSIIAPIHGSSLPRKVPVSVEQQHPEELHRRISELTVERCRVRLS 320
            :||              .....::.|:..|.           ..|.:...||    ::...:|..
Human   734 RRL--------------LQETELVEPLTPSG-----------AMPNQAQMRI----LKETELRKV 769

  Fly   321 SLLQEGTFGRVYRGTY-----NDTQDVLVKTVAQHASQMQVLLLLQEGMLLYGASHPGILSVLGV 380
            .:|..|.||.||:|.:     |....|.:|.:.::.|......:|.|..::.|...|.:..:||:
Human   770 KVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGI 834

  Fly   381 ---SIEDHTTPFVLYPAL------NNTRNLKQFLLDPACARTVTTIQIVMMASQLSMALDHLHSH 436
               |.....|..:.|..|      |..|...|.||:              ...|::..:.:|...
Human   835 CLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLN--------------WCMQIAKGMSYLEDV 885

  Fly   437 GVVHKDIATRNCVIDDQLRVKLSDSSLSR--DLFPSDYNCLGDSENRPVKWMSLEALQHKQFSEA 499
            .:||:|:|.||.::.....||::|..|:|  |:..::|:  .|....|:|||:||::..::|:..
Human   886 RLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYH--ADGGKVPIKWMALESILRRRFTHQ 948

  Fly   500 SDSWAFGVLMWELCTSAKQPYAEVDPFEMEHYLKDGYRLAQPFNCPDELFTIMAYCWALLPAERP 564
            ||.|::||.:|||.|...:||..:...|:...|:.|.||.||..|..:::.||..||.:....||
Human   949 SDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRP 1013

  Fly   565 TFAQLQSCLSEFYSQITRYV 584
            .|.:|.|..|.......|:|
Human  1014 RFRELVSEFSRMARDPQRFV 1033

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dnt	NP_001260567.1	WIF	46..182	CDD:128745
		PKc_like	310..580	CDD:304357	79/285 (28%)
		Pkinase_Tyr	317..573	CDD:285015	78/271 (29%)
ERBB2	XP_024306409.1	Recep_L_domain	52..173	CDD:307256
		Furin-like	189..384	CDD:307072
		Recep_L_domain	412..532	CDD:307256
		GF_recep_IV	557..689	CDD:317276	3/6 (50%)
		TM_ErbB2	687..730	CDD:213055	14/55 (25%)
		PTKc_HER2	758..1036	CDD:270684	83/296 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900