DRSC/TRiP Functional Genomics Resources

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Protein Alignment dnt and ERBB2

DIOPT Version :10

Sequence 1:NP_477341.2 Gene:dnt / 35207 FlyBaseID:FBgn0024245 Length:584 Species:Drosophila melanogaster
Sequence 2:NP_001369713.1 Gene:ERBB2 / 2064 HGNCID:3430 Length:1294 Species:Homo sapiens


Alignment Length:410 Identity:106/410 - (25%)
Similarity:175/410 - (42%) Gaps:75/410 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   192 DVDDPQL-LETVMLPPTGLITLVVGVSVAMGSVCLLLMIAYCVKGAANKRQHHQHGGQPMRTSSF 255
            |:||... .|....|.|.:|:.|||:        ||:::...|.|...||:.     |.:|..:.
Human   675 DLDDKGCPAEQRASPLTSIISAVVGI--------LLVVVLGVVFGILIKRRQ-----QKIRKYTM 726

  Fly   256 QRLNTHPPCQSSMGSAAYMTPSIIAPIHGSSLPRKVPVSVEQQHPEELHRRISELTVERCRVRLS 320
            :||              .....::.|:..|.           ..|.:...||    ::...:|..
Human   727 RRL--------------LQETELVEPLTPSG-----------AMPNQAQMRI----LKETELRKV 762

  Fly   321 SLLQEGTFGRVYRGTY-----NDTQDVLVKTVAQHASQMQVLLLLQEGMLLYGASHPGILSVLGV 380
            .:|..|.||.||:|.:     |....|.:|.:.::.|......:|.|..::.|...|.:..:||:
Human   763 KVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGI 827

  Fly   381 ---SIEDHTTPFVLYPAL------NNTRNLKQFLLDPACARTVTTIQIVMMASQLSMALDHLHSH 436
               |.....|..:.|..|      |..|...|.||:              ...|::..:.:|...
Human   828 CLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLN--------------WCMQIAKGMSYLEDV 878

  Fly   437 GVVHKDIATRNCVIDDQLRVKLSDSSLSR--DLFPSDYNCLGDSENRPVKWMSLEALQHKQFSEA 499
            .:||:|:|.||.::.....||::|..|:|  |:..::|:  .|....|:|||:||::..::|:..
Human   879 RLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYH--ADGGKVPIKWMALESILRRRFTHQ 941

  Fly   500 SDSWAFGVLMWELCTSAKQPYAEVDPFEMEHYLKDGYRLAQPFNCPDELFTIMAYCWALLPAERP 564
            ||.|::||.:|||.|...:||..:...|:...|:.|.||.||..|..:::.||..||.:....||
Human   942 SDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRP 1006

  Fly   565 TFAQLQSCLSEFYSQITRYV 584
            .|.:|.|..|.......|:|
Human  1007 RFRELVSEFSRMARDPQRFV 1026

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dntNP_477341.2 WIF 46..182 CDD:128745
Protein Kinases, catalytic domain 310..580 CDD:473864 79/285 (28%)
ERBB2NP_001369713.1 Recep_L_domain 52..173 CDD:460032
Furin-like 189..338 CDD:395614
Recep_L_domain 433..521 CDD:460032
GF_recep_IV 550..682 CDD:464344 3/6 (50%)
TM_ErbB2 680..723 CDD:213055 14/55 (25%)
PTKc_HER2 751..1029 CDD:270684 83/296 (28%)
Blue background indicates that the domain is not in the aligned region.

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