Protein Alignment dnt and EPHB1

DIOPT Version :10

• Sequence 1: NP_477341.2
• Gene: dnt / 35207
• FlyBaseID: FBgn0024245
• Length: 584
• Species: Drosophila melanogaster
• Sequence 2: NP_004432.1
• Gene: EPHB1 / 2047
• HGNCID: 3392
• Length: 984
• Species: Homo sapiens
• Alignment Length: 612
• Identity: 146/612 - (23%)
• Similarity: 255/612 - (41%)
• Gaps: 135/612 - (22%)

  Fly     6 KCGKSASTRNCTVKMSRKMWVLSLLALAALQLHSGSEVAAHLNVFLNP--VEVMRLLGVSAEVYY 68
            ||  .|..|:|:.......:|...|.|...:: |.|.:.||     .|  .::..:.|||::..:
Human   362 KC--RADRRSCSRCDDNVEFVPRQLGLTECRV-SISSLWAH-----TPYTFDIQAINGVSSKSPF 418

  Fly    69 VREGHIN-----NYALNFIVP----VPANVKDISFTWQSLAGRGLPYSINVVSSDQEVLPRPAIN 124
            ..: |::     |.|....||    |.|.::.|:.:|..      |...|.:..|.|:   ....
Human   419 PPQ-HVSVNITTNQAAPSTVPIMHQVSATMRSITLSWPQ------PEQPNGIILDYEI---RYYE 473

  Fly   125 VSHSGEIPTTIQTWSIALKCSGLKAAEVDVTVSLEVVLNRSLNNVTHLVFRRKKICLMNDSAEDL 189
            ..|:....:..::.:...:..||:...|      .||..|:.....:..| ..|:|.     :.|
Human   474 KEHNEFNSSMARSQTNTARIDGLRPGMV------YVVQVRARTVAGYGKF-SGKMCF-----QTL 526

  Fly   190 SEDVDDPQLLETVMLPPTGLITLVVGVSVAMGSVCLLLMIAYCV---------KGA--ANKRQHH 243
            ::|....:|.|  .||      |:.| |.|.|.|.::.::|..:         |.|  ::|.||:
Human   527 TDDDYKSELRE--QLP------LIAG-SAAAGVVFVVSLVAISIVCSRKRAYSKEAVYSDKLQHY 582

  Fly   244 QHGGQPMRTSSFQRLNTHPPCQSSMGSAAYMTPSIIAPIHGSSLPRKVPVSVEQQHPEELHRRIS 308
            ..|                  :.|.|...|:.|                  ...:.|.|..|..:
Human   583 STG------------------RGSPGMKIYIDP------------------FTYEDPNEAVREFA 611

  Fly   309 ELTVERCRVRLSSLLQEGTFGRVYRG---------TYNDTQDVLVKTVAQHASQMQVLLLLQEGM 364
            : .::...|::..::..|.||.||:|         .|     |.:||:....|:.|....|.|..
Human   612 K-EIDVSFVKIEEVIGAGEFGEVYKGRLKLPGKREIY-----VAIKTLKAGYSEKQRRDFLSEAS 670

  Fly   365 LLYGASHPGILSVLGVSIEDH----TTPFVLYPALNN--TRNLKQFLLDPACARTVTTIQIVMMA 423
            ::....||.|:.:.||..:..    .|.|:...||::  .:|..||          |.||:|.|.
Human   671 IMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQF----------TVIQLVGML 725

  Fly   424 SQLSMALDHLHSHGVVHKDIATRNCVIDDQLRVKLSDSSLSRDL-----FPSDYNCLGDSENRPV 483
            ..::..:.:|.....||:|:|.||.:::..|..|:||..|||.|     .|:..:.||.  ..||
Human   726 RGIAAGMKYLAEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGG--KIPV 788

  Fly   484 KWMSLEALQHKQFSEASDSWAFGVLMWELCTSAKQPYAEVDPFEMEHYLKDGYRLAQPFNCPDEL 548
            :|.:.||:.:::|:.|||.|::|::|||:.:..::||.::...::.:.::..|||..|.:||..|
Human   789 RWTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDCPAAL 853

  Fly   549 FTIMAYCWALLPAERPTFAQLQSCLSE 575
            ..:|..||......||.||::.:.|.:
Human   854 HQLMLDCWQKDRNSRPRFAEIVNTLDK 880

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dnt	NP_477341.2	WIF	46..182	CDD:128745	28/146 (19%)
		Protein Kinases, catalytic domain	310..580	CDD:473864	81/286 (28%)
EPHB1	NP_004432.1	EphR_LBD_B1	20..195	CDD:198444
		fn3	326..412	CDD:394996	13/57 (23%)
		fn3	435..518	CDD:394996	18/98 (18%)
		EphA2_TM	542..616	CDD:464211	19/111 (17%)
		PTKc_EphR_B	614..882	CDD:173638	81/284 (29%)
		SAM_EPH-B1	908..975	CDD:188950
		PDZ-binding. /evidence=ECO:0000255	982..984