DRSC/TRiP Functional Genomics Resources

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Protein Alignment dnt and EPHA4

DIOPT Version :10

Sequence 1:NP_477341.2 Gene:dnt / 35207 FlyBaseID:FBgn0024245 Length:584 Species:Drosophila melanogaster
Sequence 2:NP_004429.1 Gene:EPHA4 / 2043 HGNCID:3388 Length:986 Species:Homo sapiens


Alignment Length:575 Identity:124/575 - (21%)
Similarity:220/575 - (38%) Gaps:135/575 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    41 SEVAAHLNVFLNPVEVMRLLGVS---------------------AEVYYVREGHINNY--ALNFI 82
            :::.||.|.   ..|:..:.|||                     :.:..|:...:..|  ||.::
Human   401 TDLLAHTNY---TFEIWAVNGVSKYNPNPDQSVSVTVTTNQAAPSSIALVQAKEVTRYSVALAWL 462

  Fly    83 VPVPANVKDISFTWQSLAGRGLPYSINVVSSDQ-----EVLPRPAINVSHSGEIPTTIQTWSIAL 142
            .|...|            |..|.|.:.....||     .::...|.|....|..|.|...:.:..
Human   463 EPDRPN------------GVILEYEVKYYEKDQNERSYRIVRTAARNTDIKGLNPLTSYVFHVRA 515

  Fly   143 KCSGLKAAEVDVTVSLEVVLNRSLNNVTHLVFRRKKICLMNDSAEDLSEDVDDPQLLETVMLPPT 207
            :.:   |...|.:..|||..|...:.:            :.|.|.            .||:|   
Human   516 RTA---AGYGDFSEPLEVTTNTVPSRI------------IGDGAN------------STVLL--- 550

  Fly   208 GLITLVVGVSVAMGSVCL--LLMIAYCVKGAANKRQHHQHGGQPMRTSSFQRLNTHPPCQSSMGS 270
                    |||: |||.|  :|:.|:.:     .|:..::..........:.||        .|.
Human   551 --------VSVS-GSVVLVVILIAAFVI-----SRRRSKYSKAKQEADEEKHLN--------QGV 593

  Fly   271 AAYMTPSIIAPIHGSSLPRKVPVSVEQQHPEELHRRISELTVERCRVRLSSLLQEGTFGRVYRGT 335
            ..|:.|                  ...:.|.:..|..::.....| :::..::..|.||.|..|.
Human   594 RTYVDP------------------FTYEDPNQAVREFAKEIDASC-IKIEKVIGVGEFGEVCSGR 639

  Fly   336 YNDTQD----VLVKTVAQHASQMQVLLLLQEGMLLYGASHPGILSVLGVSIEDHTTPFVLYPALN 396
            ......    |.:||:....:..|....|.|..::....||.|:.:.||..:       ..|.:.
Human   640 LKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQFDHPNIIHLEGVVTK-------CKPVMI 697

  Fly   397 NTRNLKQFLLDPACART---VTTIQIVMMASQLSMALDHLHSHGVVHKDIATRNCVIDDQLRVKL 458
            .|..::...||....:.   .|.||:|.|...:...:.:|.....||:|:|.||.:::..|..|:
Human   698 ITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKV 762

  Fly   459 SDSSLSR---DLFPSDYNCLGDSENRPVKWMSLEALQHKQFSEASDSWAFGVLMWELCTSAKQPY 520
            ||..:||   |...:.|...|.  ..|::|.:.||:.:::|:.|||.|::|::|||:.:..::||
Human   763 SDFGMSRVLEDDPEAAYTTRGG--KIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPY 825

  Fly   521 AEVDPFEMEHYLKDGYRLAQPFNCPDELFTIMAYCWALLPAERPTFAQLQSCLSE 575
            .::...::...:::||||..|.:||..|..:|..||....::||.|.|:.:.|.:
Human   826 WDMSNQDVIKAIEEGYRLPPPMDCPIALHQLMLDCWQKERSDRPKFGQIVNMLDK 880

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dntNP_477341.2 WIF 46..182 CDD:128745 28/163 (17%)
Protein Kinases, catalytic domain 310..580 CDD:473864 73/276 (26%)
EPHA4NP_004429.1 EphR_LBD_A4 30..203 CDD:198450
FN3 329..436 CDD:238020 7/37 (19%)
FN3 441..532 CDD:238020 21/105 (20%)
EphA2_TM 562..618 CDD:464211 10/86 (12%)
PTKc_EphR_A 616..882 CDD:270651 73/275 (27%)
SAM_EPH-A4 911..981 CDD:188944
PDZ-binding. /evidence=ECO:0000255 984..986
Blue background indicates that the domain is not in the aligned region.

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