Protein Alignment dnt and Ryk

DIOPT Version :9

• Sequence 1: NP_001260567.1
• Gene: dnt / 35207
• FlyBaseID: FBgn0024245
• Length: 584
• Species: Drosophila melanogaster
• Sequence 2: NP_038677.3
• Gene: Ryk / 20187
• MGIID: 101766
• Length: 594
• Species: Mus musculus
• Alignment Length: 598
• Identity: 226/598 - (37%)
• Similarity: 332/598 - (55%)
• Gaps: 64/598 - (10%)

  Fly    26 VLSLLALAALQLHSGSEVAA-----HLNVFLNPVEVMRLLGVSAEVYYVREGHINNYALNFIVPV 85
            :|.|||:..........:||     .::::|:..||.||||:.||:||||...|::|||:|.:.|
Mouse    22 LLLLLAMLPAAAPRSPALAAAPAGPSVSLYLSEDEVRRLLGLDAELYYVRNDLISHYALSFNLLV 86

  Fly    86 PANVKDISFTWQSLAGRGLPYSINVVSSDQEVLPRPAINVSHSGEIPTTIQTWSIALKCSGLKAA 150
            |:....:.|||.  |...:.|.:.....:...:..|.:|:|..||:|.|:..:.:.|.|:|...:
Mouse    87 PSETNFLHFTWH--AKSKVEYKLGFQVDNFVAMGMPQVNISAQGEVPRTLSVFRVELSCTGKVDS 149

  Fly   151 EVDVTVSLEVVLNRSLNNVTHLVFRRKKICL-----MNDSAED--LSEDVDDPQLLETVMLPPTG 208
            ||.:.:.|.:.:|.| .|.|.|.|:|:|:|.     :..||.|  .|..:.||     |...||
Mouse   150 EVMILMQLNLTVNSS-KNFTVLNFKRRKMCYKKLEEVKTSALDKNTSRTIYDP-----VHAAPT- 207

  Fly   209 LITLVVGVSVAMGSVCLLLMIAYCVKGAANKRQHHQHGGQPMR-------TSSFQRLNTHPPCQS 266
            ..|.|..:||  |..|.::.:...:....     |.|..:.:.       :||.|.|:     |.
Mouse   208 TSTRVFYISV--GVCCAVIFLVAIILAVL-----HLHSMKRIELDDSISASSSSQGLS-----QP 260

  Fly   267 SMGSAAYM---TPSIIAPIHGSS-LPRKVPVSVEQQHPE-----ELHRRISELTVERCRVRLSSL 322
            |..:..|:   ||:...||..|| .|   .:.:|:....     |...::.::.:.|.|:.|..:
Mouse   261 STQTTQYLRADTPNNATPITSSSGYP---TLRIEKNDLRSVTLLEAKAKVKDIAISRERITLKDV 322

  Fly   323 LQEGTFGRVYRGTYNDTQD------VLVKTVAQHASQMQVLLLLQEGMLLYGASHPGILSVLGVS 381
            ||||||||::.|...|.:|      ..||||...||::||.::|.|...|.|..|..:|.:..|.
Mouse   323 LQEGTFGRIFHGILVDEKDPNKEKQTFVKTVKDQASEVQVTMMLTESCKLRGLHHRNLLPITHVC 387

  Fly   382 IEDHTTPFVLYPALNNTRNLKQF-----LLDPACARTVTTIQIVMMASQLSMALDHLHSHGVVHK 441
            ||:...|.|:.|.: |..|||.|     |::....:.::...:|.||.|::..:.:|....|:|:
Mouse   388 IEEGEKPMVVLPYM-NWGNLKLFLRQCKLVEANNPQAISQQDLVHMAIQIACGMSYLARREVIHR 451

  Fly   442 DIATRNCVIDDQLRVKLSDSSLSRDLFPSDYNCLGDSENRPVKWMSLEALQHKQFSEASDSWAFG 506
            |:|.|||||||.|:||::|::|||||||.||:||||:|||||:||:||:|.:.:||.|||.||||
Mouse   452 DLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNENRPVRWMALESLVNNEFSSASDVWAFG 516

  Fly   507 VLMWELCTSAKQPYAEVDPFEMEHYLKDGYRLAQPFNCPDELFTIMAYCWALLPAERPTFAQLQS 571
            |.:|||.|..:.||.::|||||..|||||||:|||.|||||||.:||.||||.|.|||.|.||..
Mouse   517 VTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQ 581

  Fly   572 CLSEFYSQITRYV 584
            ||:||::.:..||
Mouse   582 CLTEFHAALGAYV 594

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dnt	NP_001260567.1	WIF	46..182	CDD:128745	47/140 (34%)
		PKc_like	310..580	CDD:304357	138/280 (49%)
		Pkinase_Tyr	317..573	CDD:285015	132/266 (50%)
Ryk	NP_038677.3	WIF	47..180	CDD:128745	47/135 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	250..283		11/37 (30%)
		PTK_Ryk	310..590	CDD:270639	138/280 (49%)
		Pkinase_Tyr	317..583	CDD:285015	132/266 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	269	1.000	Domainoid score	I1833
eggNOG	1	0.900	-	-		E1_KOG1025
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	361	1.000	Inparanoid score	I2184
Isobase	1	0.950	-	0	Normalized mean entropy	S3376
OMA	1	1.010	-	-		QHG45854
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005256
OrthoInspector	1	1.000	-	-		otm43395
orthoMCL	1	0.900	-	-		OOG6_106190
Panther	1	1.100	-	-	LDO	PTHR24416
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3316
SonicParanoid	1	1.000	-	-		X3777
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.810