Protein Alignment dnt and frk-1

DIOPT Version :10

• Sequence 1: NP_477341.2
• Gene: dnt / 35207
• FlyBaseID: FBgn0024245
• Length: 584
• Species: Drosophila melanogaster
• Sequence 2: NP_001369901.1
• Gene: frk-1 / 191635
• WormBaseID: WBGene00001487
• Length: 390
• Species: Caenorhabditis elegans
• Alignment Length: 436
• Identity: 100/436 - (22%)
• Similarity: 186/436 - (42%)
• Gaps: 61/436 - (13%)

  Fly   148 KAAEVDVTVSLEVVLNRSLNNVTHLVFRRKKICLMNDSAEDLSEDVDDPQLLETVMLPPTGLITL 212
            |::..|.:|:.::   ||......:|.|:        .||...:...|..:.:|..:|  |.:.|
 Worm     6 KSSNNDASVTDDI---RSAEYYHGMVPRQ--------DAEGFLKREGDFLVRKTEQMP--GKVVL 57

  Fly   213 VVGVSVAMGSVCLLLMIAYCVKGAANKRQHHQHGGQPMRTSSFQRLNTHPPCQSSMGSAAYMTPS 277
            .:.|.|. ..:|...|:.  :...:|| .:.:|..|....|  :.:|.|...::.:.:|:
 Worm    58 AMSVRVT-DELCRHFMLN--MDPTSNK-FYFEHTHQESTIS--ELINWHMTTKTPISAAS----- 111

  Fly   278 IIAPIHGSSLPRKVPVSVEQQHPEELHRRISELTVERCRVRLSSLLQEGTFGRVYRGTYND--TQ 340
                  |:.:.|          |.|.    |...:....:..:..|.||.||.|:....:.  .|
 Worm   112 ------GAKIRR----------PMER----SPWLINHDSIVANKKLGEGAFGDVFIAELDQGGKQ 156

  Fly   341 DVLVKTVAQHASQMQVLLLLQEGMLLYGASHPGILSVLGVSIEDHTTPFVLYPALNNTRNLKQFL 405
            :|.|||:...|::...|..::|..|:....|..::.::||:|.:|....|:....|.:      |
 Worm   157 EVAVKTMRAEATREARLRFMKEARLMRKYQHKHVVKLIGVAIHEHPLMIVMEYCPNGS------L 215

  Fly   406 LDPACARTVTTIQIVMMASQLSMALDHLHSHGVVHKDIATRNCVIDDQLRVKLSDSSLS--RDLF 468
            |.......|:.|:.:...::.:..:.:|.....:|:|||.|||::..:..:|:||..:|  :|..
 Worm   216 LSHLKKNKVSLIEKLRFTTEAADGIAYLERSKCIHRDIAARNCLLSAKNELKISDFGMSDNKDEI 280

  Fly   469 PSDYNCLGDSENRPVKWMSLEALQHKQFSEASDSWAFGVLMWELCTSAKQPYAEVDPFEME-HYL 532
            ..:     ..|..|:||::.|.:|.|.::..:|.|.||||:||:.:...:||..:...:.. ..:
 Worm   281 KDE-----TLEKVPIKWLAPETMQEKVYTHKTDIWTFGVLVWEIYSDGAEPYPGLTKIQTRAKIV 340

  Fly   533 KDGYRLAQPFNC-PDELFTIMAYCWALLPAERPTFAQLQSCLSEFY 577
            .:.||:..|... |.....:...||...|.:|.|...:...|.|||
 Worm   341 VNDYRMKMPDGTHPTVADVVTGTCWQKNPEKRSTMDSIHKKLREFY 386

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dnt	NP_477341.2	WIF	46..182	CDD:128745	7/33 (21%)
		Protein Kinases, catalytic domain	310..580	CDD:473864	69/274 (25%)
frk-1	NP_001369901.1	SH2_Fps_family	16..107	CDD:198224	22/109 (20%)
		TyrKc	131..382	CDD:197581	65/261 (25%)