Protein Alignment dnt and Insr

DIOPT Version :10

• Sequence 1: NP_477341.2
• Gene: dnt / 35207
• FlyBaseID: FBgn0024245
• Length: 584
• Species: Drosophila melanogaster
• Sequence 2: NP_001316985.1
• Gene: Insr / 16337
• MGIID: 96575
• Length: 1384
• Species: Mus musculus
• Alignment Length: 415
• Identity: 115/415 - (27%)
• Similarity: 192/415 - (46%)
• Gaps: 75/415 - (18%)

  Fly   189 LSEDVDDPQLLETVMLPPTGLITLVVGVSVAMGSVCLLLMIAYCVKGAANKRQHHQHGGQPMRTS 253
            :::.:|.|..:..:::.|   :..|...||.:||:.|.|          .|||.....| |:..|
Mouse   946 VTDYLDVPSNIAKIIIGP---LIFVFLFSVVIGSIYLFL----------RKRQPDGPMG-PLYAS 996

  Fly   254 SFQRLNTHPPCQSSMGSAAYMTPSIIAPIHGSSLPRKVPVSVEQQHPEELHRRISELTVERCRVR 318
            |               :..|::.|.:       .|..|.|..|.:.|.|             ::.
Mouse   997 S---------------NPEYLSASDV-------FPSSVYVPDEWEVPRE-------------KIT 1026

  Fly   319 LSSLLQEGTFGRVYRGTYND------TQDVLVKTVAQHASQMQVLLLLQEGMLLYGASHPGILSV 377
            |...|.:|:||.||.|...|      ...|.||||.:.||..:.:..|.|..::.|.:...::.:
Mouse  1027 LLRELGQGSFGMVYEGNAKDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRL 1091

  Fly   378 LGVSIEDHTTPFVLYPALNNTRNLKQFL--LDPAC----ARTVTTIQ-IVMMASQLSMALDHLHS 435
            |||..:...|..|:  .|....:||..|  |.|..    .|...|:| ::.|.::::..:.:|::
Mouse  1092 LGVVSKGQPTLVVM--ELMAHGDLKSHLRSLRPDAENNPGRPPPTLQEMIQMTAEIADGMAYLNA 1154

  Fly   436 HGVVHKDIATRNCVIDDQLRVKLSDSSLSRDLFPSDYNCLGDSENRPVKWMSLEALQHKQFSEAS 500
            ...||:|:|.|||::.....||:.|..::||::.:||...|.....||:|||.|:|:...|:.:|
Mouse  1155 KKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTASS 1219

  Fly   501 DSWAFGVLMWELCTSAKQPYAEVDPFEMEHYLKDGYRLAQPFNCPDELFTIMAYCWALLPAERPT 565
            |.|:|||::||:.:.|:|||..:...::..::.||..|..|.|||:.|..:|..||...|..|||
Mouse  1220 DMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDPPDNCPERLTDLMRMCWQFNPKMRPT 1284

  Fly   566 FAQLQSCLSE-----------FYSQ 579
            |.::.:.|.:           |||:
Mouse  1285 FLEIVNLLKDDLHPSFPEVSFFYSE 1309

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dnt	NP_477341.2	WIF	46..182	CDD:128745
		Protein Kinases, catalytic domain	310..580	CDD:473864	90/294 (31%)
Insr	NP_001316985.1	Recep_L_domain	52..164	CDD:460032
		Furin-like	179..337	CDD:395614
		Recep_L_domain	359..472	CDD:460032
		FN3	<584..>660	CDD:442628
		FN3	624..>667	CDD:238020
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	688..709
		Insulin-binding. /evidence=ECO:0000250	735..743
		FN3	869..946	CDD:238020	115/415 (28%)
		Insulin_TMD	942..989	CDD:465543	13/55 (24%)
		Important for interaction with IRS1, SHC1 and STAT5B. /evidence=ECO:0000250	998..1001		0/2 (0%)
		PTKc_InsR	1018..1305	CDD:133192	89/301 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1361..1384
		PIK3R1 binding. /evidence=ECO:0000250	1363..1366