DRSC/TRiP Functional Genomics Resources

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Protein Alignment dnt and Igf1r

DIOPT Version :10

Sequence 1:NP_477341.2 Gene:dnt / 35207 FlyBaseID:FBgn0024245 Length:584 Species:Drosophila melanogaster
Sequence 2:XP_006540704.1 Gene:Igf1r / 16001 MGIID:96433 Length:1401 Species:Mus musculus


Alignment Length:429 Identity:101/429 - (23%)
Similarity:187/429 - (43%) Gaps:108/429 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   209 LITLVVGVSVAMGSVCLLLMIAYCVKGAANKRQHHQHGGQPMRTSSFQRLNTHPPCQSSMGSAAY 273
            :|.|.|.:.:.:|.:.::|.:.:      .||.:.:.|...:..|                    
Mouse   939 IIALPVAILLIVGGLVIMLYVFH------RKRNNSRLGNGVLYAS-------------------- 977

  Fly   274 MTPSIIAPIHGSSLPRKVPVSVEQQHPEELHRRISELTVERCRVRLSSLLQEGTFGRVY----RG 334
                 :.|.:.|:....||               .|..|.|.::.::..|.:|:||.||    :|
Mouse   978 -----VNPEYFSAADVYVP---------------DEWEVAREKITMNRELGQGSFGMVYEGVAKG 1022

  Fly   335 TYNDTQD--VLVKTVAQHASQMQVLLLLQEGMLL--YGASHPGILSVLGVSIEDHTTPFVLYPAL 395
            ...|..:  |.:|||.:.||..:.:..|.|..::  :...|  ::.:|||..:...|..::  .|
Mouse  1023 VVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHH--VVRLLGVVSQGQPTLVIM--EL 1083

  Fly   396 NNTRNLKQFLLD----------------PACARTV-----------------------TTIQIVM 421
            ....:||.:|..                |...||:                       :..:::.
Mouse  1084 MTRGDLKSYLRSLRPEVEPRLSWNSLRRPGWPRTLRDSLASVSQVLALKQNNLVLIPPSLSKMIQ 1148

  Fly   422 MASQLSMALDHLHSHGVVHKDIATRNCVIDDQLRVKLSDSSLSRDLFPSDYNCLGDSENRPVKWM 486
            ||.:::..:.:|:::..||:|:|.|||::.:...||:.|..::||::.:||...|.....||:||
Mouse  1149 MAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWM 1213

  Fly   487 SLEALQHKQFSEASDSWAFGVLMWELCTSAKQPYAEVDPFEMEHYLKDGYRLAQPFNCPDELFTI 551
            |.|:|:...|:..||.|:|||::||:.|.|:|||..:...::..::.:|..|.:|.||||.||.:
Mouse  1214 SPESLKDGVFTTHSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFEL 1278

  Fly   552 MAYCWALLPAERPTFAQLQSCLSE-----------FYSQ 579
            |..||...|..||:|.::...:.:           :||:
Mouse  1279 MRMCWQYNPKMRPSFLEIIGSIKDEMEPSFQEVSFYYSE 1317

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dntNP_477341.2 WIF 46..182 CDD:128745
Protein Kinases, catalytic domain 310..580 CDD:473864 87/328 (27%)
Igf1rXP_006540704.1 Recep_L_domain 51..161 CDD:460032
Furin-like 175..330 CDD:395614
Recep_L_domain 353..468 CDD:460032
FN3 494..607 CDD:238020
FN3 612..>656 CDD:238020
FN3 837..926 CDD:238020
PTKc_InsR_like 994..1302 CDD:173625 85/311 (27%)
Blue background indicates that the domain is not in the aligned region.

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