Protein Alignment dnt and Fgfr3

DIOPT Version :10

• Sequence 1: NP_477341.2
• Gene: dnt / 35207
• FlyBaseID: FBgn0024245
• Length: 584
• Species: Drosophila melanogaster
• Sequence 2: NP_001156689.1
• Gene: Fgfr3 / 14184
• MGIID: 95524
• Length: 802
• Species: Mus musculus
• Alignment Length: 521
• Identity: 142/521 - (27%)
• Similarity: 224/521 - (42%)
• Gaps: 69/521 - (13%)

  Fly    85 VPANVKDISFTWQSLAGRGLPYSINVVSSDQ---EVLPRPAINVSHSGEIPTTIQTWSIALKCSG 146
            :|||       ..::.|..:.:...|.|..|   :.|....:|.|..|...|...|   .||...
Mouse   253 LPAN-------QTAILGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVT---VLKSWI 307

  Fly   147 LKAAEVDVTVSLEVVLNRS----LNNVTHLVFRRKKICLMNDSAEDLSEDVDDPQLLETVMLPPT 207
            .:..|.|..:.|..|..|.    |...|:.:...:|...:.         |..||..|..::...
Mouse   308 SENVEADARLRLANVSERDGGEYLCRATNFIGVAEKAFWLR---------VHGPQAAEEELMETD 363

  Fly   208 GLITLVVGVSVAMGSVCLLLMIAYCVKGAANKRQHHQHG-GQPM--RTSSFQ-RLNTHPPCQSSM 268
            ...::..|| ::.|.|..|.::..........|...:.| |.|.  :.|.|. :........|||
Mouse   364 EAGSVYAGV-LSYGVVFFLFILVVAAVILCRLRSPPKKGLGSPTVHKVSRFPLKRQVSLESNSSM 427

  Fly   269 GSAAYMTPSI-IAPIHGSSLPRKVPVSVEQQHPEELHRRISELTVERCRVRLSSLLQEGTFGRVY 332
            .|   .||.: ||.:.....|....|| |.:.|.:....:|     |.|:.|...|.||.||:|.
Mouse   428 NS---NTPLVRIARLSSGEGPVLANVS-ELELPADPKWELS-----RTRLTLGKPLGEGCFGQVV 483

  Fly   333 R----GTYNDTQ----DVLVKTVAQHASQMQVLLLLQE-GMLLYGASHPGILSVLGVSIEDHTTP 388
            .    |...|..    .|.||.:...|:...:..|:.| .|:.....|..|:::||...:....
Mouse   484 MAEAIGIDKDRTAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPL- 547

  Fly   389 FVL--YPALNNTRNLKQFL-------LD---PAC---ARTVTTIQIVMMASQLSMALDHLHSHGV 438
            :||  |.|..   ||::||       :|   .||   ...:|...:|..|.|::..:::|.|...
Mouse   548 YVLVEYAAKG---NLREFLRARRPPGMDYSFDACRLPEEQLTCKDLVSCAYQVARGMEYLASQKC 609

  Fly   439 VHKDIATRNCVIDDQLRVKLSDSSLSRDLFPSDYNCLGDSENRPVKWMSLEALQHKQFSEASDSW 503
            :|:|:|.||.::.:...:|::|..|:||:...||.....:...|||||:.|||..:.::..||.|
Mouse   610 IHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVW 674

  Fly   504 AFGVLMWELCTSAKQPYAEVDPFEMEHYLKDGYRLAQPFNCPDELFTIMAYCWALLPAERPTFAQ 568
            :||||:||:.|....||..:...|:...||:|:|:.:|.:|..:|:.||..||..:|::||||.|
Mouse   675 SFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPASCTHDLYMIMRECWHAVPSQRPTFKQ 739

  Fly   569 L 569
            |
Mouse   740 L 740

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dnt	NP_477341.2	WIF	46..182	CDD:128745	23/103 (22%)
		Protein Kinases, catalytic domain	310..580	CDD:473864	90/284 (32%)
Fgfr3	NP_001156689.1	ig	46..110	CDD:395002
		Ig strand B	55..59	CDD:409353
		Ig strand C	69..73	CDD:409353
		Ig strand E	91..94	CDD:409353
		Ig strand F	104..108	CDD:409353
		IgI_2_FGFR	145..239	CDD:409443
		Ig strand A	145..148	CDD:409443
		Ig strand A'	156..161	CDD:409443
		Ig strand B	165..173	CDD:409443
		Ig strand C	179..184	CDD:409443
		Ig strand C'	187..189	CDD:409443
		Ig strand D	198..201	CDD:409443
		Ig strand E	205..210	CDD:409443
		Ig strand F	219..226	CDD:409443
		Ig strand G	229..239	CDD:409443
		IgI_3_FGFR	247..347	CDD:409363	23/103 (22%)
		Ig strand A	247..250	CDD:409363
		Ig strand A'	254..258	CDD:409363	3/10 (30%)
		Ig strand B	266..273	CDD:409363	1/6 (17%)
		Ig strand C	277..284	CDD:409363	1/6 (17%)
		Ig strand D	299..304	CDD:409363	1/7 (14%)
		Ig strand E	315..320	CDD:409363	0/4 (0%)
		Ig strand F	328..336	CDD:409363	1/7 (14%)
		Ig strand G	339..347	CDD:409363	1/7 (14%)
		PTKc_FGFR3	455..788	CDD:173652	92/295 (31%)