DRSC/TRiP Functional Genomics Resources

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Protein Alignment dnt and Fgfr2

DIOPT Version :10

Sequence 1:NP_477341.2 Gene:dnt / 35207 FlyBaseID:FBgn0024245 Length:584 Species:Drosophila melanogaster
Sequence 2:NP_034337.2 Gene:Fgfr2 / 14183 MGIID:95523 Length:840 Species:Mus musculus


Alignment Length:671 Identity:158/671 - (23%)
Similarity:267/671 - (39%) Gaps:132/671 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 SVNKCGKSASTRNCTVKMSRKMWVLSLLALAALQLHSGSEVAAHLNVFLNPVEVMRLLGVSAEV- 66
            |.|:..:.|.....|.||.:::..:........:..:|.          ||...||.|....|. 
Mouse   164 SENRSNQRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGG----------NPTPTMRWLKNGKEFK 218

  Fly    67 -------YYVREGHINNYALNFIVPVPANVKDISFTWQSLAGR-GLPYSINVVSSD------QEV 117
                   |.||..|   ::|.....||::..:.:...::..|. ...|.::||...      |..
Mouse   219 QEHRIGGYKVRNQH---WSLIMESVVPSDKGNYTCLVENEYGSINHTYHLDVVERSPHRPILQAG 280

  Fly   118 LPRPAINVSHSGEIPTTIQTWSIA------------------------LKCSGLKAAEVDVT-VS 157
            ||..|..|. .|::....:.:|.|                        ||.  ||||.|:.| ..
Mouse   281 LPANASTVV-GGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKV--LKAAGVNTTDKE 342

  Fly   158 LEVVLNRSL------------NNVTHLVFRRKKICLMNDSAEDLSEDVDDPQLLETVMLPPTGLI 210
            :||:..|::            .|...:.|....:.::.....: .|....|..||        :.
Mouse   343 IEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPVRE-KEITASPDYLE--------IA 398

  Fly   211 TLVVGVSVAMGSVCLLLMIAYCVKGAANKRQHHQHGGQP------MRTSSFQRLNTHPPCQSSMG 269
            ...:||.:.   .|:::.:.:|......|:.  ....||      .|....:::.......|||.
Mouse   399 IYCIGVFLI---ACMVVTVIFCRMKTTTKKP--DFSSQPAVHKLTKRIPLRRQVTVSAESSSSMN 458

  Fly   270 SAAYMTPSIIAPIHGSS---LPRKVPVSVEQQHPEELHRRISELTVERCRVRLSSLLQEGTFGRV 331
            |   .||.:......||   .|....|| |.:.||:     .:....|.::.|...|.||.||:|
Mouse   459 S---NTPLVRITTRLSSTADTPMLAGVS-EYELPED-----PKWEFPRDKLTLGKPLGEGCFGQV 514

  Fly   332 Y--------RGTYNDTQDVLVKTVAQHASQMQVLLLLQE-GMLLYGASHPGILSVLGVSIEDHTT 387
            .        :....:...|.||.:...|::..:..|:.| .|:.....|..|:::||...:|  .
Mouse   515 VMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQD--G 577

  Fly   388 PFVLYPALNNTRNLKQFL-------------LDPACARTVTTIQIVMMASQLSMALDHLHSHGVV 439
            |..:.....:..||:::|             ::......:|...:|....||:..:::|.|...:
Mouse   578 PLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCI 642

  Fly   440 HKDIATRNCVIDDQLRVKLSDSSLSRDLFPSDYNCLGDSENRPVKWMSLEALQHKQFSEASDSWA 504
            |:|:|.||.::.:...:|::|..|:||:...||.....:...|||||:.|||..:.::..||.|:
Mouse   643 HRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWS 707

  Fly   505 FGVLMWELCTSAKQPYAEVDPFEMEHYLKDGYRLAQPFNCPDELFTIMAYCWALLPAERPTFAQL 569
            |||||||:.|....||..:...|:...||:|:|:.:|.||.:||:.:|..||..:|::||||.||
Mouse   708 FGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPTNCTNELYMMMRDCWHAVPSQRPTFKQL 772

  Fly   570 QSCL--------SEFYSQITR 582
            ...|        :|.|..:|:
Mouse   773 VEDLDRILTLTTNEEYLDLTQ 793

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dntNP_477341.2 WIF 46..182 CDD:128745 38/187 (20%)
Protein Kinases, catalytic domain 310..580 CDD:473864 86/299 (29%)
Fgfr2NP_034337.2 Ig 50..143 CDD:472250
Ig strand B 77..81 CDD:409353
Ig strand C 88..92 CDD:409353
Ig strand E 109..113 CDD:409353
Ig strand F 123..128 CDD:409353
Ig strand G 136..139 CDD:409353
IgI_2_FGFR 173..267 CDD:409443 19/106 (18%)
Ig strand A 173..176 CDD:409443 0/2 (0%)
Ig strand A' 184..189 CDD:409443 0/4 (0%)
Ig strand B 193..201 CDD:409443 0/7 (0%)
Ig strand C 207..212 CDD:409443 2/4 (50%)
Ig strand C' 215..217 CDD:409443 0/1 (0%)
Ig strand D 226..229 CDD:409443 1/2 (50%)
Ig strand E 233..238 CDD:409443 1/4 (25%)
Ig strand F 247..254 CDD:409443 0/6 (0%)
Ig strand G 257..267 CDD:409443 2/9 (22%)
IgI_3_FGFR2 275..379 CDD:409444 21/106 (20%)
Ig strand A 275..278 CDD:409444 0/2 (0%)
Ig strand A' 282..286 CDD:409444 1/3 (33%)
Ig strand B 294..301 CDD:409444 0/6 (0%)
Ig strand C 305..312 CDD:409444 0/6 (0%)
Ig strand D 327..332 CDD:409444 2/6 (33%)
Ig strand E 344..349 CDD:409444 2/4 (50%)
Ig strand F 357..365 CDD:409444 0/7 (0%)
Ig strand G 368..376 CDD:409444 1/7 (14%)
PTKc_FGFR2 475..787 CDD:270679 90/319 (28%)
Blue background indicates that the domain is not in the aligned region.

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