DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dnt and Ryk

DIOPT Version :9

Sequence 1:	NP_001260567.1	Gene:	dnt / 35207	FlyBaseID:	FBgn0024245	Length:	584	Species:	Drosophila melanogaster
Sequence 2:	NP_536327.1	Gene:	Ryk / 140585	RGDID:	620549	Length:	594	Species:	Rattus norvegicus

Alignment Length:	598	Identity:	227/598 - (37%)
Similarity:	332/598 - (55%)	Gaps:	64/598 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 VLSLLALAALQLHSGSEVAA-----HLNVFLNPVEVMRLLGVSAEVYYVREGHINNYALNFIVPV 85
            :|.|||:..........:||     .::::|:..||.||||:.||:||||...|::|||:|.:.|
  Rat    22 LLLLLAMLPAAAPRSPALAAAPAGPSVSLYLSEDEVRRLLGLDAELYYVRNDLISHYALSFNLLV 86

  Fly    86 PANVKDISFTWQSLAGRGLPYSINVVSSDQEVLPRPAINVSHSGEIPTTIQTWSIALKCSGLKAA 150
            |:....:.|||.  |...:.|.:.....:...:..|.:|:|..||:|.|:..:.:.|.|:|...:
  Rat    87 PSETNFLHFTWH--AKSKVEYKLGFQVDNFVAMGMPQVNISAQGEVPRTLSVFRVELSCTGKVDS 149

  Fly   151 EVDVTVSLEVVLNRSLNNVTHLVFRRKKICL-----MNDSAED--LSEDVDDPQLLETVMLPPTG 208
            ||.:.:.|.:.:|.| .|.|.|.|:|:|:|.     :..||.|  .|..:.||     |...||
  Rat   150 EVMILMQLNLTVNSS-KNFTVLNFKRRKMCYKKLEEVKTSALDKNTSRTIYDP-----VHAAPT- 207

  Fly   209 LITLVVGVSVAMGSVCLLLMIAYCVKGAANKRQHHQHGGQPMR-------TSSFQRLNTHPPCQS 266
            ..|.|..:||  |..|.::.:...:....     |.|..:.:.       :||.|.|:     |.
  Rat   208 TSTRVFYISV--GVCCAVIFLVAIILAVL-----HLHSMKRIELDDSISASSSSQGLS-----QP 260

  Fly   267 SMGSAAYM---TPSIIAPIHGSS-LPRKVPVSVEQQHPE-----ELHRRISELTVERCRVRLSSL 322
            |..:..|:   ||:...|:..|| .|   .:.:|:....     |...::.::.:.|.||.|..:
  Rat   261 STQTTQYLRADTPNNATPVTSSSGYP---TLRIEKNDLRSVTLLEAKAKVKDIAISRERVTLKDV 322

  Fly   323 LQEGTFGRVYRGTYNDTQD------VLVKTVAQHASQMQVLLLLQEGMLLYGASHPGILSVLGVS 381
            ||||||||::.|...|.:|      ..||||...||::||.::|.|...|.|..|..:|.:..|.
  Rat   323 LQEGTFGRIFHGILVDEKDPNKEKQTFVKTVKDQASEVQVTMMLTESCKLRGLHHRNLLPITHVC 387

  Fly   382 IEDHTTPFVLYPALNNTRNLKQF-----LLDPACARTVTTIQIVMMASQLSMALDHLHSHGVVHK 441
            ||:...|.|:.|.: |..|||.|     |::....:.::...:|.||.|::..:.:|....|:||
  Rat   388 IEEGEKPMVISPYM-NWGNLKLFLRQCKLVEANNPQAISQQDLVHMAIQIACGMSYLARREVIHK 451

  Fly   442 DIATRNCVIDDQLRVKLSDSSLSRDLFPSDYNCLGDSENRPVKWMSLEALQHKQFSEASDSWAFG 506
            |:|.|||||||.|:||::|::|||||||.||:||||:|||||:||:||:|.:.:||.|||.||||
  Rat   452 DLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNENRPVRWMALESLVNNEFSSASDVWAFG 516

  Fly   507 VLMWELCTSAKQPYAEVDPFEMEHYLKDGYRLAQPFNCPDELFTIMAYCWALLPAERPTFAQLQS 571
            |.:|||.|..:.||.::|||||..|||||||:|||.|||||||.:||.||||.|.|||.|.||..
  Rat   517 VTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQ 581

  Fly   572 CLSEFYSQITRYV 584
            ||:||::.:..||
  Rat   582 CLTEFHAALGAYV 594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dnt	NP_001260567.1	WIF	46..182	CDD:128745	47/140 (34%)
		PKc_like	310..580	CDD:304357	140/280 (50%)
		Pkinase_Tyr	317..573	CDD:285015	134/266 (50%)
Ryk	NP_536327.1	WIF	47..180	CDD:128745	47/135 (35%)
		PTK_Ryk	310..590	CDD:270639	140/280 (50%)
		Pkinase_Tyr	317..583	CDD:285015	134/266 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	270	1.000	Domainoid score	I1758
eggNOG	1	0.900	-	-		E1_KOG1025
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	362	1.000	Inparanoid score	I2121
OMA	1	1.010	-	-		QHG45854
OrthoDB	1	1.010	-	-		D359098at33208
OrthoFinder	1	1.000	-	-		FOG0005256
OrthoInspector	1	1.000	-	-		otm45465
orthoMCL	1	0.900	-	-		OOG6_106190
Panther	1	1.100	-	-	LDO	PTHR24416
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3777
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.840