DRSC/TRiP Functional Genomics Resources

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Protein Alignment dnt and Erbb3

DIOPT Version :9

Sequence 1:NP_001260567.1 Gene:dnt / 35207 FlyBaseID:FBgn0024245 Length:584 Species:Drosophila melanogaster
Sequence 2:NP_034283.1 Gene:Erbb3 / 13867 MGIID:95411 Length:1339 Species:Mus musculus


Alignment Length:301 Identity:81/301 - (26%)
Similarity:146/301 - (48%) Gaps:20/301 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly   294 SVEQQHPEELHRRISELTVERCRVRLSSLLQEGTFGRVYRGTYNDTQD-----VLVKTVAQHASQ 353
            |:|...|.|...::.....:...:|...:|..|.||.|::|.:....:     |.:| |.:..|.
Mouse   684 SIEPLDPSEKANKVLARIFKETELRKLKVLGSGVFGTVHKGIWIPEGESIKIPVCIK-VIEDKSG 747

  Fly   354 MQVLLLLQEGMLLYGA-SHPGILSVLGV----SIEDHTTPFVLYPALNNTRNLKQFLLDPACART 413
            .|....:.:.||..|: .|..|:.:||:    |::..|....|...|::.|..::         |
Mouse   748 RQSFQAVTDHMLAVGSLDHAHIVRLLGLCPGSSLQLVTQYLPLGSLLDHVRQHRE---------T 803

  Fly   414 VTTIQIVMMASQLSMALDHLHSHGVVHKDIATRNCVIDDQLRVKLSDSSLSRDLFPSDYNCLGDS 478
            :....::....|::..:.:|..|.:||:|:|.||.::....:|:::|..::..|.|.|...|...
Mouse   804 LGPQLLLNWGVQIAKGMYYLEEHSMVHRDLALRNVMLKSPSQVQVADFGVADLLPPDDKQLLHSE 868

  Fly   479 ENRPVKWMSLEALQHKQFSEASDSWAFGVLMWELCTSAKQPYAEVDPFEMEHYLKDGYRLAQPFN 543
            ...|:|||:||::...:::..||.|::||.:|||.|...:|||.:...|:...|:.|.|||||..
Mouse   869 AKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEIPDLLEKGERLAQPQI 933

  Fly   544 CPDELFTIMAYCWALLPAERPTFAQLQSCLSEFYSQITRYV 584
            |..:::.:|..||.:....||||.:|.:..:.......||:
Mouse   934 CTIDVYMVMVKCWMIDENIRPTFKELANEFTRMARDPPRYL 974

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dntNP_001260567.1 WIF 46..182 CDD:128745
PKc_like 310..580 CDD:304357 75/279 (27%)
Pkinase_Tyr 317..573 CDD:285015 75/265 (28%)
Erbb3NP_034283.1 Recep_L_domain 56..167 CDD:279382
Furin-like 179..329 CDD:279142
FU 180..215 CDD:214589
FU 226..266 CDD:238021
Recep_L_domain 353..474 CDD:279382
GF_recep_IV 499..630 CDD:291509
FU 500..542 CDD:238021
FU 548..592 CDD:214589
TM_ErbB3 638..674 CDD:213056
PKc_like 699..977 CDD:304357 77/286 (27%)
Pkinase_Tyr 707..963 CDD:285015 75/265 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1028..1052
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1077..1156
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1181..1212
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1025
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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