DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment dnt and MERTK

DIOPT Version :10

Sequence 1:NP_477341.2 Gene:dnt / 35207 FlyBaseID:FBgn0024245 Length:584 Species:Drosophila melanogaster
Sequence 2:NP_006334.2 Gene:MERTK / 10461 HGNCID:7027 Length:999 Species:Homo sapiens


Alignment Length:552 Identity:135/552 - (24%)
Similarity:227/552 - (41%) Gaps:105/552 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   104 LPYSINVVSSDQEVLPRPAINVSHSGEIP-TTIQTWSIALKCSGL-KAAEVDVTVSLEVVLNRSL 166
            ||:...:  ...:.|...:|.||...||. :.:..|.:|....|. ..|.::||    |.||.|.
Human   340 LPHLYQI--KQLQALANYSIGVSCMNEIGWSAVSPWILASTTEGAPSVAPLNVT----VFLNESS 398

  Fly   167 NNVT-------------HLV-FRRKKICLMNDSAEDLSEDV------------------------ 193
            :||.             .|| :|...:......:::|.|:|                        
Human   399 DNVDIRWMKPPTKQQDGELVGYRISHVWQSAGISKELLEEVGQNGSRARISVQVHNATCTVRIAA 463

  Fly   194 ---------DDPQLLETVMLPPTGLITLVVGVSVAMGSVCLLLMIAYCVKG------------AA 237
                     .||   ..:.:|..|.:......:.|.|:...:|:|..|..|            |.
Human   464 VTRGGVGPFSDP---VKIFIPAHGWVDYAPSSTPAPGNADPVLIIFGCFCGFILIGLILYISLAI 525

  Fly   238 NKRQHHQHGGQPMRTSSFQRLNTHPPCQSSMGSAAYMTPSIIAPIHGSSLPRKVPVSVEQQHPEE 302
            .||......|........:.:..:      :...::...:|...:|...:            .||
Human   526 RKRVQETKFGNAFTEEDSELVVNY------IAKKSFCRRAIELTLHSLGV------------SEE 572

  Fly   303 LHRRISELTVERCRVRLSSLLQEGTFGRVYRGTYND----TQDVLVKTV-AQHASQMQVLLLLQE 362
            |..::.::.::|..:.|..:|.||.||.|..|....    :..|.|||: ..::||.::...|.|
Human   573 LQNKLEDVVIDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSE 637

  Fly   363 GMLLYGASHPGILSVLGVSIEDHT---------TPFVLYPALNNTRNLKQFLLDPACARTVTTIQ 418
            ...:...|||.::.:|||.||..:         .||:.|..|:......:....|......|.::
Human   638 AACMKDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLK 702

  Fly   419 IVMMASQLSMALDHLHSHGVVHKDIATRNCVIDDQLRVKLSDSSLSRDLFPSDYNCLGDSENRPV 483
            .::   .:::.:::|.:...:|:|:|.|||::.|.:.|.::|..||:.::..||...|.....||
Human   703 FMV---DIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPV 764

  Fly   484 KWMSLEALQHKQFSEASDSWAFGVLMWELCTSAKQPYAEVDPFEMEHYLKDGYRLAQPFNCPDEL 548
            ||:::|:|..:.::..||.|||||.|||:.|....||..|...||..||..|:||.||.:|.|||
Human   765 KWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDEL 829

  Fly   549 FTIMAYCWALLPAERPTFAQLQSCLSEFYSQI 580
            :.||..||...|.:||||:.|:..|.:....:
Human   830 YEIMYSCWRTDPLDRPTFSVLRLQLEKLLESL 861

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dntNP_477341.2 WIF 46..182 CDD:128745 23/93 (25%)
Protein Kinases, catalytic domain 310..580 CDD:473864 90/283 (32%)
MERTKNP_006334.2 Ig 111..176 CDD:409353
Ig strand B 111..115 CDD:409353
Ig strand C 127..131 CDD:409353
Ig strand E 158..162 CDD:409353
Ig strand F 172..176 CDD:409353
IgI_2_Axl_Tyro3_like 198..279 CDD:409407
Ig strand A 198..201 CDD:409407
Ig strand A' 204..208 CDD:409407
Ig strand B 212..221 CDD:409407
Ig strand C 226..233 CDD:409407
Ig strand C' 235..238 CDD:409407
Ig strand E 243..254 CDD:409407
Ig strand F 257..266 CDD:409407
Ig strand G 270..279 CDD:409407
FN3 284..378 CDD:238020 10/39 (26%)
FN3 386..478 CDD:238020 17/98 (17%)
PTKc_Mer 579..862 CDD:271106 90/286 (31%)
Blue background indicates that the domain is not in the aligned region.

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