DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dnt and si:ch73-383l1.1

DIOPT Version :9

Sequence 1:	NP_001260567.1	Gene:	dnt / 35207	FlyBaseID:	FBgn0024245	Length:	584	Species:	Drosophila melanogaster
Sequence 2:	XP_021331611.1	Gene:	si:ch73-383l1.1 / 101885162	ZFINID:	ZDB-GENE-121214-64	Length:	1392	Species:	Danio rerio

Alignment Length:	324	Identity:	81/324 - (25%)
Similarity:	137/324 - (42%)	Gaps:	66/324 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   292 PVSVEQQHPEELHRRISELTVERCRVRLSSLLQEGTFGRVYRGTYNDTQD-----VLVKTVAQHA 351
            |::.....|.:...||.:.| |..||:   :|..|.||.||:|.:....:     |.:|.:.:..
Zfish   686 PLTPSGTAPNQAQLRILKET-ELKRVK---ILGTGAFGTVYKGIWVPEGETVKIPVAIKILNEST 746

  Fly   352 SQMQVLLLLQEGMLLYGASHPGILSVLGVSIEDHTTPFVLYPALNNTRNLKQFLLDPACARTVTT 416
            .....:..:.|.:::....||.::.:|||                        .|.|       |
Zfish   747 GPKANVEFMDEALIMASMEHPHLVRLLGV------------------------CLSP-------T 780

  Fly   417 IQIVMMASQLSMALDHLHSH--------------------------GVVHKDIATRNCVIDDQLR 455
            ||:|.........||::|.|                          .:||:|:|.||.::.....
Zfish   781 IQLVTQLMPHGCLLDYVHEHQDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNH 845

  Fly   456 VKLSDSSLSRDLFPSDYNCLGDSENRPVKWMSLEALQHKQFSEASDSWAFGVLMWELCTSAKQPY 520
            :|::|..|:|.|..::.....|....|:|||:||.:.:::|:..||.|::||.:|||.|...:||
Zfish   846 IKITDFGLARLLETNEKEYSADEGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPY 910

  Fly   521 AEVDPFEMEHYLKDGYRLAQPFNCPDELFTIMAYCWALLPAERPTFAQLQSCLSEFYSQITRYV 584
            ..:...|:...|:.|.||.||..|..:::.:|..||.:....||.|.:|.:..|.......||:
Zfish   911 DGIPTREIPDILEKGERLPQPPICTIDVYMVMVKCWMIDADSRPRFKELAAEFSRMARDPQRYL 974

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dnt	NP_001260567.1	WIF	46..182	CDD:128745
		PKc_like	310..580	CDD:304357	75/300 (25%)
		Pkinase_Tyr	317..573	CDD:285015	71/286 (25%)
si:ch73-383l1.1	XP_021331611.1	Recep_L_domain	54..166	CDD:307256
		Furin-like	183..331	CDD:307072
		Recep_L_domain	357..477	CDD:307256
		GF_recep_IV	501..633	CDD:317276
		TM_ErbB4	631..674	CDD:213053
		PKc_like	699..995	CDD:328722	79/311 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900