Protein Alignment dnt and ephb4

DIOPT Version :10

• Sequence 1: NP_477341.2
• Gene: dnt / 35207
• FlyBaseID: FBgn0024245
• Length: 584
• Species: Drosophila melanogaster
• Sequence 2: XP_031755496.1
• Gene: ephb4 / 100497297
• XenbaseID: XB-GENE-5881604
• Length: 945
• Species: Xenopus tropicalis
• Alignment Length: 560
• Identity: 134/560 - (23%)
• Similarity: 228/560 - (40%)
• Gaps: 122/560 - (21%)

  Fly    79 LNFIVPVPANVKD-----------ISFTWQSLAGRG---------LPYSINVVSSDQEVLPRPAI 123
            ||| .|.|..:.|           :::.::.||..|         |...:| |::|::| |.|..
 Frog   376 LNF-TPRPQRLVDRRLRVAGLRPRVTYNFRVLALNGVSERSTSGALGEEVN-VTTDRDV-PLPVS 437

  Fly   124 NVSHSGEIPTTIQ-TWSIALKCSGLKAAEVDV------------------TVSLEVVLNRSLNNV 169
            .:.......||:. .|:..|..:..|...:|.                  |.|.|.:|...|:..
 Frog   438 GIQQMAASETTLTLRWATPLHSAPTKGNILDYEVKYYAKDQEKPLIKFMKTTSNEALLAELLSGT 502

  Fly   170 THLVFRRKKICLMND------SAEDLSEDVDDPQLLETVMLPPTGLITLVVGVSVAMGSVCLLLM 228
            .::|..|.:    .:      |.:.|.:.::.|:..:    |...||....||..       ||:
 Frog   503 VYVVQVRAR----TEAGYGAFSGDTLVQTLEGPEKAQ----PQVALIAGTAGVGT-------LLV 552

  Fly   229 IAYCVKGAANKRQHHQHGGQPMRTSSFQRLNTHPPCQSSMG--SAAYMTPSIIAPIHGSSLPRKV 291
            :|..|......|:|         .||.:......|.|..:|  |..|:.|
 Frog   553 LAVIVTAVVCIRKH---------GSSKEPEYCDKPGQYLIGHNSKVYIDP--------------- 593

  Fly   292 PVSVEQQHPEELHRRISELTVERCRVRLSSLLQEGTFGRVYRGTY----NDTQDVLVKTVAQHAS 352
               ...:.|.|..|..::.....| |::..::..|.||.|.||..    .....|.:||:....:
 Frog   594 ---FTYEDPNEAVREFAKEIDVSC-VKIEEVIGAGEFGEVCRGRLKVPGKKENYVAIKTLKGGYT 654

  Fly   353 QMQVLLLLQEGMLLYGASHPGILSVLGVSIEDHTTPFVLYPALNN-------TRNLKQFLLDPAC 410
            :.|....|.|..::...:||.|:.:.|| |.::....::...:.|       .:|..||
 Frog   655 ERQRREFLSEASIMGQFNHPNIIHLEGV-ITNNCPVMIITEYMENGALDSFLRQNDGQF------ 712

  Fly   411 ARTVTTIQIVMMASQLSMALDHLHSHGVVHKDIATRNCVIDDQLRVKLSDSSLSRDL-----FPS 470
                |.||:|.|...::..:.:|.....||:|:|.||.:::..|..|:||..|||.|     .|:
 Frog   713 ----TPIQLVGMLRGIASGMRYLAEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLQEGSTDPT 773

  Fly   471 DYNCLGDSENRPVKWMSLEALQHKQFSEASDSWAFGVLMWELCTSAKQPYAEVDPFEMEHYLKDG 535
            ..:|||.  ..|::|.:.||:..::|:.|||.|.:|::|||:.:..::||.::...::.:.::..
 Frog   774 YTSCLGG--KIPIRWTAPEAIAFRKFTSASDVWGYGIVMWEVMSFGERPYWDMSNQDVINAIEQD 836

  Fly   536 YRLAQPFNCPDELFTIMAYCWALLPAERPTFAQLQSCLSE 575
            |||..|.:||..|..:|..||....|.||.||.:.|.|.:
 Frog   837 YRLPAPPDCPTALHQLMLDCWQRDRALRPRFADIVSSLDK 876

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dnt	NP_477341.2	WIF	46..182	CDD:128745	29/141 (21%)
		Protein Kinases, catalytic domain	310..580	CDD:473864	80/282 (28%)
ephb4	XP_031755496.1	EphR_LBD_B4	17..196	CDD:198442
		FN3	<321..>548	CDD:442628	36/182 (20%)
		EphA2_TM	541..612	CDD:464211	20/104 (19%)
		PTKc_EphR_B	610..878	CDD:173638	80/281 (28%)
		SAM_superfamily	907..>945	CDD:472832