DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment dnt and erbb2

DIOPT Version :10

Sequence 1:NP_477341.2 Gene:dnt / 35207 FlyBaseID:FBgn0024245 Length:584 Species:Drosophila melanogaster
Sequence 2:XP_002940420.3 Gene:erbb2 / 100492078 XenbaseID:XB-GENE-5938588 Length:1323 Species:Xenopus tropicalis


Alignment Length:645 Identity:139/645 - (21%)
Similarity:236/645 - (36%) Gaps:164/645 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    35 LQLHSGSEVAAHLNVFLNPVEVM--RLLGVSAEVYYVREGHINNYALNFIVPVPANV------KD 91
            :.:.|..|....||||.| :.|:  |:|...|....:|...|::..|..:..|.:.:      .|
 Frog   410 IYIESWPEELKSLNVFEN-LRVIHGRMLQNGAYSLVLRNLSISHLGLRSLTEVSSGLVLIEGNPD 473

  Fly    92 ISF----TWQSLAGRGLPYSINVVSSDQEVLPRPAINVSH--SGEIPTTIQTW----SIALKCSG 146
            :.|    .|.||........:..::..||...:...|...  .|.     :.|    |..::|:|
 Frog   474 LCFLESAPWASLFRNPRQTILKTINKPQEACDQEGQNCFSRCDGN-----KCWGPGPSQCVRCNG 533

  Fly   147 LKAAEVDVTVSLEVVLNRSLNNVTHLVFRRKKICLMNDSAED--LSEDVDDPQLL--ETVMLPPT 207
                                       |.|...|:.:.:..|  ..|.|:..|.:  ....||..
 Frog   534 ---------------------------FLRGHDCIESCNVLDGYPREHVNGSQCVPCHPQCLPQN 571

  Fly   208 GLITLVVGVSVAMGSVCLLLMIAYCVKGAANKRQHHQHG-------GQPMRTSSFQRLNTHPP-- 263
            |.:|            |.......|::.|     |:..|       ...::.:||..:..:|.  
 Frog   572 GTLT------------CNGTEAHQCMECA-----HYLDGEDCVEQCPSGVKGNSFVPIWKYPDKD 619

  Fly   264 ---------CQSSM-------------GSAAYMTPSIIAPI---------------HGSSLPRK- 290
                     |..|.             .|..||..||:..|               ....|.:| 
 Frog   620 RICQLCNVNCSHSCNQLDERGCPILPDNSQVYMVASIVISILIVITISTAIVLYIRRRKQLKKKH 684

  Fly   291 -----------VPVSVEQQHPEELHRRISELTVERCRVRLSSLLQEGTFGRVYRGTY-----NDT 339
                       .|::.....|.:...||    ::...::...:|..|.||.||:|.:     |..
 Frog   685 TMRRLLQDELVEPLTPSGAIPNQAQMRI----LKETELKKMMILGSGAFGTVYKGIWIPDGENIK 745

  Fly   340 QDVLVKTVAQHASQMQVLLLLQEGMLLYGASHPGILSVLGVSIEDHTTPFVLYPALNNTRNLKQF 404
            ..|.:|.:.::.|......:|.|..::.|...|.:..:||:             .|.:|..|...
 Frog   746 IPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVCRLLGI-------------CLTSTVQLVTQ 797

  Fly   405 LLDPAC--------ARTVTTIQIVMMASQLSMALDHLHSHGVVHKDIATRNCVIDDQLRVKLSDS 461
            |:...|        ...:.:..::....|::..:.:|....:||:|:|.||.::.....||::|.
 Frog   798 LMPYGCLLDYVRENKDRIASRDLLNWCVQIAKGMTYLEDVRLVHRDLAARNVLVKSPSHVKITDF 862

  Fly   462 SLSR--DLFPSDYNCLGDSENRPVKWMSLEALQHKQFSEASDSWAFGVLMWELCTSAKQPYAEVD 524
            .|:|  |:..::|:  .|....|:|||:||::.|::|:..||.|::||.:|||.|...:||..:.
 Frog   863 GLARLLDVDETEYH--ADGGKVPIKWMALESILHRRFTHQSDVWSYGVTVWELMTFGAKPYDGIP 925

  Fly   525 PFEMEHYLKDGYRLAQPFNCPDELFTIMAYCWALLPAERPTFAQLQSCLSEFYSQITRYV 584
            ..|:...|:.|.||.||..|..:::.||..||.:....||.|..|...||......:|||
 Frog   926 AREIPDLLEKGERLPQPPVCTIDVYMIMVKCWMIDSEFRPKFRDLVGELSRMARDPSRYV 985

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dntNP_477341.2 WIF 46..182 CDD:128745 29/153 (19%)
Protein Kinases, catalytic domain 310..580 CDD:473864 75/284 (26%)
erbb2XP_002940420.3 Recep_L_domain 56..168 CDD:460032
Furin-like 184..340 CDD:395614
Recep_L_domain 366..479 CDD:460032 17/69 (25%)
GF_recep_IV 511..642 CDD:464344 26/179 (15%)
PTKc_HER2 710..988 CDD:270684 80/295 (27%)
COG4372 <1153..>1317 CDD:443500
CwlO1 <1161..>1232 CDD:443091
Blue background indicates that the domain is not in the aligned region.

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