Protein Alignment dnt and mst1ra

DIOPT Version :10

• Sequence 1: NP_477341.2
• Gene: dnt / 35207
• FlyBaseID: FBgn0024245
• Length: 584
• Species: Drosophila melanogaster
• Sequence 2: XP_005166175.1
• Gene: mst1ra / 100002448
• ZFINID: ZDB-GENE-071218-2
• Length: 1356
• Species: Danio rerio
• Alignment Length: 760
• Identity: 175/760 - (23%)
• Similarity: 303/760 - (39%)
• Gaps: 230/760 - (30%)

  Fly    15 NCTV---KMSRKMWVLSLLALAALQLHSGSEVAAHLNVFLNPVEVMRLLGVSAEVYYVREGHINN 76
            :|||   |.|.     |||....:...||...:.::.:.:|..:       :...|:: .|....
Zfish   596 DCTVVPEKTSS-----SLLVCRIVGEESGLHQSVNITIQVNEKK-------AGSGYFI-SGKAGI 647

  Fly    77 YALNFIVPVPANVKDIS--------FTWQSLAGRGLPY--SINVVSSDQEVLPRPAINVSHSGEI 131
            ...:|:.|   .:.|||        .|..:|:|:.|..  |..:...|:..   |..:||..|.
Zfish   648 QGFSFVTP---EITDISPSFGPKIGGTLITLSGKHLDAGGSRTISLGDRNC---PVESVSSDGT- 705

  Fly   132 PTTIQTWSIALKCSGLK-AAEVDVTVSLEVVLNRSLNNVTHLV------------FRR-KKICLM 182
                   ||..:..|:| ..||||.|.::.....|....::.|            ||| .||.:.
Zfish   706 -------SIVCRSEGVKDTLEVDVKVVIDGSTISSTKTFSYRVNPEVTGVNPNCGFRRGSKIIIT 763

  Fly   183 NDSAEDLSEDV-------DDPQLLETV------------MLP----PTGLITL------------ 212
            ..:.:.:|:.|       .||  :|||            |.|    .||::::
Zfish   764 GQNLDSVSQAVIKYKGGYKDP--VETVCSGQGNPTQMECMSPVCEESTGILSVDLDGAKDLQSQT 826

  Fly   213 -----------------VVGVSVAMGSVCL----LLMIAYCV----------------------- 233
                             |:.:|.....|.|    |.:::.|:
Zfish   827 FTCHANGEPIPFETEDRVLELSPGQDEVSLHHKKLALVSGCMEIIMTVNGVDCNAKVLDNEITCR 891

  Fly   234 ---------KGAANK----RQHHQHGGQPMRTSSF------------------------------ 255
                     :||..|    |:.|..|...|:.|:.
Zfish   892 IPKNLTIPRQGAPVKVLVNREEHDIGMVVMKNSNLIVGVVLGILAAVGVGAAIVYVAMAQERKKK 956

  Fly   256 ------QRLNTHPPCQSSMGSAA---------YMTPSI------IAPIHGS-----SLP------ 288
                  .||:.|    |:..:|.         |...::      ::|.|||     |||
Zfish   957 KAALVEVRLSMH----SNRTTAENYDRSPDGDYRRETVRPAGLSVSPFHGSGTTFTSLPYAGSMD 1017

  Fly   289 ------RKVPVSVEQQHPEELHRRISEL-TVERCRVRLSSLLQEGTFGRVYRGTYNDTQD----V 342
                  .:..||:....|:.|....:.| :.::.:::...::.:|.||.||.|...|:.:    .
Zfish  1018 SAAAPLMRRQVSMSALRPDLLEEVKNVLISPDKIKIQHEQIIGKGHFGTVYHGYLTDSDNKETHC 1082

  Fly   343 LVKTVAQHASQMQVLLLLQEGMLLYGASHPGILSVLGVSIEDHTTPFVLYPALNNTRNLKQFLLD 407
            .||::.:.....:|...|:||:.:....|..:||:||:.:.....|.|:.|.:.: .:|:.|:..
Zfish  1083 AVKSLNRITDLEEVEQFLREGLFMKAFHHSHVLSLLGIVLPSDGLPLVILPYMKH-GDLRHFIRS 1146

  Fly   408 PACARTVTTIQIVMMASQLSMALDHLHSHGVVHKDIATRNCVIDDQLRVKLSDSSLSRDLFPSDY 472
            |  .|:.|...::....|::..:::|.:...||:|:|.|||::|:...||::|..::||::..:|
Zfish  1147 P--ERSPTVKDLIGFGLQVAKGMEYLANKKFVHRDLAARNCMLDESFTVKVADFGMARDVYDKEY 1209

  Fly   473 NCLGDSENR--PVKWMSLEALQHKQFSEASDSWAFGVLMWELCTSAKQPYAEVDPFEMEHYLKDG 535
            ..:.||:..  |||||:||:||.::|:..||.|::|||||||.|....||.:|||:::..||..|
Zfish  1210 YSIQDSKKAKLPVKWMALESLQTQKFTTKSDVWSYGVLMWELLTRGASPYPDVDPYDITPYLMQG 1274

  Fly   536 YRLAQPFNCPDELFTIMAYCWALLPAERPTFAQLQSCLSEFYSQI 580
            .||.||..|.|.|::::..||...|.:||.|..|...:.:.:|.:
Zfish  1275 RRLPQPQYCFDSLWSVLMQCWHPEPEKRPGFTTLVQAVQDIHSSL 1319

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dnt	NP_477341.2	WIF	46..182	CDD:128745	34/159 (21%)
		Protein Kinases, catalytic domain	310..580	CDD:473864	89/276 (32%)
mst1ra	XP_005166175.1	Sema_MET_like	41..504	CDD:200509
		PSI	507..549	CDD:396154
		IPT	550..654	CDD:472823	14/70 (20%)
		IPT_plexin_repeat2	655..740	CDD:238584	24/98 (24%)
		IPT	742..828	CDD:214657	16/87 (18%)
		PTKc_Met_Ron	1057..1318	CDD:270649	87/263 (33%)