Protein Alignment gammaTub37C and TUBA4A

DIOPT Version :10

• Sequence 1: NP_476922.1
• Gene: gammaTub37C / 35199
• FlyBaseID: FBgn0010097
• Length: 457
• Species: Drosophila melanogaster
• Sequence 2: XP_047301630.1
• Gene: TUBA4A / 7277
• HGNCID: 12407
• Length: 457
• Species: Homo sapiens
• Alignment Length: 442
• Identity: 139/442 - (31%)
• Similarity: 239/442 - (54%)
• Gaps: 19/442 - (4%)

  Fly     4 EIITLQLGQCGNQIGFEFWKRLCLEHGISPDGVLEDFAT--DGQDRKDVFFYQADDNHYIPRAVL 66
            |.|::.:||.|.|:|...|:..||||||.|||.:....|  .|.|....||.:.....::||||.
Human    12 ECISVHVGQAGVQMGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFTTFFCETGAGKHVPRAVF 76

  Fly    67 IDLEPRVINNIMTSPYSKLYNQENVFLSKHGGGAGNNWASG-FSQGEKVQEEVFDILDREADGSD 130
            :||||.||:.|...||.:|::.|.:...|.  .|.||:|.| ::.|:::.:.|.|.:.:.:|...
Human    77 VDLEPTVIDEIRNGPYRQLFHPEQLITGKE--DAANNYARGHYTIGKEIIDPVLDRIRKLSDQCT 139

  Fly   131 SLEGFVLCHSIAGGTGSGMGSYVLERLSERFPKKLIQTYSVFPNQDEISDVVVQPYNSILTLKRL 195
            .|:||::.||..||||||..|.::||||..:.||....:|::| ..::|..||:|||||||....
Human   140 GLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYP-APQVSTAVVEPYNSILTTHTT 203

  Fly   196 TKCADSVVVLDNTALNRIATERLHIQTPTFTQINNLVSTIMSLSTTTLRYPSYMNNNLIGLTASL 260
            .:.:|...::||.|:..|....|.|:.||:|.:|.|:|.|:|..|.:||:...:|.:|.....:|
Human   204 LEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTNL 268

  Fly   261 IPTPQLHFLMTGYTPLMSDCETKTSVRKTTVLDVMRRLLQPKNMMVSALTDKQSRQCFVSILNII 325
            :|.|::||.:..|.|::|  ..|....:.:|.::.....:|.|.||..  |.:..: :::...:.
Human   269 VPYPRIHFPLATYAPVIS--AEKAYHEQLSVAEITNACFEPANQMVKC--DPRHGK-YMACCLLY 328

  Fly   326 QGEVDPSQVHKSLQRIRERKLANFIPWGPASIQVALPRSSPYVQSAHKVSGL-----MMANHTGI 385
            :|:|.|..|:.::..|:.::...|:.|.|...:|.:....|.|.....::.:     |::|.|.|
Human   329 RGDVVPKDVNAAIAAIKTKRSIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAI 393

  Fly   386 SSLFKRALAQYDKLRKRNAFLDNFRRESMFQDDLTELDIARDTVDCLVQEYE 437
            :..:.|...::|.:..:.||:..:..|.|.:.:.:|   ||:.:..|.::||
Human   394 AEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSE---AREDMAALEKDYE 442

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gammaTub37C	NP_476922.1	gamma_tubulin	4..436	CDD:276957	137/439 (31%)
TUBA4A	XP_047301630.1	PTZ00335	11..457	CDD:185562	139/442 (31%)