DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gammaTub37C and gtb1

DIOPT Version :9

Sequence 1:	NP_001260565.1	Gene:	gammaTub37C / 35199	FlyBaseID:	FBgn0010097	Length:	457	Species:	Drosophila melanogaster
Sequence 2:	NP_596147.1	Gene:	gtb1 / 2540223	PomBaseID:	SPBC32F12.04	Length:	446	Species:	Schizosaccharomyces pombe

Alignment Length:	445	Identity:	299/445 - (67%)
Similarity:	364/445 - (81%)	Gaps:	3/445 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPSEIITLQLGQCGNQIGFEFWKRLCLEHGISPDGVLEDFATDGQDRKDVFFYQADDNHYIPRAV 65
            |..||||||.||||||||.:||::|||||||.|||.||.|||:|.|||||||||:||..|||||:
pombe     1 MGREIITLQAGQCGNQIGSQFWQQLCLEHGIGPDGTLESFATEGVDRKDVFFYQSDDTRYIPRAI 65

  Fly    66 LIDLEPRVINNIMTSPYSKLYNQENVFLSKHGGGAGNNWASGFSQGEKVQEEVFDILDREADGSD 130
            ||||||||:|||::..|..|||.||:.::|:|||||||||:|:|..|::.|::.|::||||||||
pombe    66 LIDLEPRVVNNILSDTYGSLYNPENILITKNGGGAGNNWANGYSHAERIFEDIMDMIDREADGSD 130

  Fly   131 SLEGFVLCHSIAGGTGSGMGSYVLERLSERFPKKLIQTYSVFPNQDEISDVVVQPYNSILTLKRL 195
            |||||.|.||||||||||:||::||||::|:|||:|||||||||...:||||||||||:|.||||
pombe   131 SLEGFSLLHSIAGGTGSGLGSFLLERLNDRYPKKIIQTYSVFPNSQSVSDVVVQPYNSLLALKRL 195

  Fly   196 TKCADSVVVLDNTALNRIATERLHIQTPTFTQINNLVSTIMSLSTTTLRYPSYMNNNLIGLTASL 260
            |..|||||||||.||..||.:|||.|.|||.|.|.||||:||.||||||||.||||:|:.:.|||
pombe   196 TLNADSVVVLDNAALAHIAADRLHTQNPTFHQQNQLVSTVMSASTTTLRYPGYMNNDLVSIIASL 260

  Fly   261 IPTPQLHFLMTGYTPLMS-DCETKTSVRKTTVLDVMRRLLQPKNMMVSALTDKQSRQCFVSILNI 324
            ||:|:.|||:|.|||..: ..|...::|||||||||||||.|||.|||....|:|  ||:|||:|
pombe   261 IPSPRCHFLLTSYTPFTNQQVEEAKAIRKTTVLDVMRRLLLPKNQMVSVNPSKKS--CFISILDI 323

  Fly   325 IQGEVDPSQVHKSLQRIRERKLANFIPWGPASIQVALPRSSPYVQSAHKVSGLMMANHTGISSLF 389
            ||||.||:.|||||.|||||:.|:|||||||||||||.:.|||:::.|:|||||:||||.|:|||
pombe   324 IQGEADPADVHKSLLRIRERRYASFIPWGPASIQVALSKKSPYIKTNHRVSGLMLANHTSIASLF 388

  Fly   390 KRALAQYDKLRKRNAFLDNFRRESMFQDDLTELDIARDTVDCLVQEYEAATQIDY 444
            ||.|.|||:||||||||:.:::|::|:|||.|.|.:||.|..|:.||||....:|
pombe   389 KRTLDQYDRLRKRNAFLEQYKKEAIFEDDLNEFDSSRDVVADLINEYEACEDPNY 443

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gammaTub37C	NP_001260565.1	PLN00222	1..447	CDD:215108	299/445 (67%)
gammaTub37C	NP_001260565.1	gamma_tubulin	4..436	CDD:276957	293/432 (68%)
gtb1	NP_596147.1	PLN00222	1..444	CDD:215108	299/445 (67%)
gtb1	NP_596147.1	gamma_tubulin	3..435	CDD:276957	293/433 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	329	1.000	Domainoid score	I213
eggNOG	1	0.900	-	-		E1_COG5023
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H833
Inparanoid	1	1.050	630	1.000	Inparanoid score	I140
OMA	1	1.010	-	-		QHG53966
OrthoFinder	1	1.000	-	-		FOG0002428
OrthoInspector	1	1.000	-	-		otm47237
orthoMCL	1	0.900	-	-		OOG6_101897
Panther	1	1.100	-	-	O	PTHR11588
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1481
SonicParanoid	1	1.000	-	-		X1612
TreeFam	1	0.960	-	-
	14	13.860