Protein Alignment CG17568 and ZNF335

DIOPT Version :10

• Sequence 1: NP_609951.2
• Gene: CG17568 / 35198
• FlyBaseID: FBgn0032763
• Length: 513
• Species: Drosophila melanogaster
• Sequence 2: NP_071378.1
• Gene: ZNF335 / 63925
• HGNCID: 15807
• Length: 1342
• Species: Homo sapiens
• Alignment Length: 518
• Identity: 112/518 - (21%)
• Similarity: 173/518 - (33%)
• Gaps: 176/518 - (33%)

  Fly    93 ETDGDQEMDVAALRQQFGLCDDDWTHIIKPIPALEMESDNVYQKPAELLKDFPLAETSSQEMEIS 157
            |.:|.:|.|           |||   |:......::|.|:.| .|||       .|...:::.:.
Human   296 EEEGPEEED-----------DDD---IVDAGAIDDLEEDSDY-NPAE-------DEPRGRQLRLQ 338

  Fly   158 KRTTTTHLIQTKKNVEMEIPKQEFIDL-----GPILLEKNTSQLDMEDVLDELPQE--------- 208
            :.|.:|...:.:.....::|:.|..||     |..|:...:.|...|....|.|..
Human   339 RPTPSTPRPRRRPGRPRKLPRLEISDLPDGVEGEPLVSSQSGQSPPEPQDPEAPSSSGPGHLVAM 403

  Fly   209 -ELSQPRLDSTTSPASMENDVKSEMLDSCEGDDDFLPVDGQLMDLVAVATTPNTLESTAEEKAKR 272
             ::|:..:::..|.:..||     ...||..:.|.||                         .:|
Human   404 GKVSRTPVEAGVSQSDAEN-----AAPSCPDEHDTLP-------------------------RRR 438

  Fly   273 GRMDCEKCGKVYRNRASYEKHLERECRRIERRVKVDKTTTTCDICNKTLSSATALKLH------- 330
            ||......||.||      |:..:..:.:.|       ...|.||.....|...|:.|
Human   439 GRPSRRFLGKKYR------KYYYKSPKPLLR-------PFLCRICGSRFLSHEDLRFHVNSHEAG 490

  Fly   331 --------------------KEGI--HQNVKPYICDSCGKQLKTITALNEHKLVHTESR------ 367
                                ||.:  |...|||.||.|.........:..|..||:..|
Human   491 DPQLFKCLQCSYRSRRWSSLKEHMFNHVGSKPYKCDECSYTSVYRKDVIRHAAVHSRDRKKRPDP 555

  Fly   368 -----PFECTVCKAGFKNRARLKAHYQIHA-EPSFVCNICGKKLQTRRTWNMHKVVHTE---ERR 423
                 .|.|.||...:..:.||..|.:.|: |...:|:.|||..:.|.|:.||.:.|.:   .||
Human   556 TPKLSSFPCPVCGRVYPMQKRLTQHMKTHSTEKPHMCDKCGKSFKKRYTFKMHLLTHIQAVANRR 620

  Fly   424 LKCDVCGALFKRSKTLKTHLLSHTGLRPYVCNYC--------------------GKSFAC----- 463
            .||:.|..:.:..|.|..|.|||...:|:.|::|                    .|.|||
Human   621 FKCEFCEFVCEDKKALLNHQLSHVSDKPFKCSFCPYRTFREDFLLSHVAVKHTGAKPFACEYCHF 685

  Fly   464 ----NANCRSHKL-----------KKHPQEVQQEDGARLPSR----LNVPTLDELRVMTQKLP 507
                ..|.|.|..           ::||:|.        |||    .::..::||:......|
Human   686 STRHKKNLRLHVRCRHASSFEEWGRRHPEEP--------PSRRRPFFSLQQIEELKQQHSAAP 740

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG17568	NP_609951.2	zf-AD	10..87	CDD:214871
		COG5048	<313..471	CDD:227381	57/230 (25%)
		C2H2 Zn finger	314..335	CDD:275368	8/49 (16%)
		C2H2 Zn finger	343..363	CDD:275368	4/19 (21%)
		C2H2 Zn finger	371..391	CDD:275368	6/19 (32%)
		C2H2 Zn finger	398..418	CDD:275368	8/19 (42%)
		C2H2 Zn finger	426..446	CDD:275368	6/19 (32%)
		C2H2 Zn finger	454..475	CDD:275368	9/60 (15%)
ZNF335	NP_071378.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..102
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	201..228
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	274..442		39/197 (20%)
		C2H2 Zn finger	467..487	CDD:275368	6/19 (32%)
		C2H2 Zn finger	497..517	CDD:275368	2/19 (11%)
		zf-H2C2_2	509..534	CDD:463886	9/24 (38%)
		zf-H2C2_5	523..546	CDD:404746	6/22 (27%)
		C2H2 Zn finger	529..545	CDD:275370	1/15 (7%)
		C2H2 Zn finger	564..584	CDD:275368	6/19 (32%)
		zf-H2C2_2	576..601	CDD:463886	9/24 (38%)
		C2H2 Zn finger	592..612	CDD:275368	8/19 (42%)
		C2H2 Zn finger	623..643	CDD:275368	6/19 (32%)
		C2H2 Zn finger	651..672	CDD:275368	2/20 (10%)
		C2H2 Zn finger	680..699	CDD:275368	4/18 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	732..763		2/9 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	964..1013
		C2H2 Zn finger	1021..1041	CDD:275368
		Involved in the interaction with CCAR2. /evidence=ECO:0000269|PubMed:19131338	1041..1342
		C2H2 Zn finger	1049..1069	CDD:275368
		zf-H2C2_5	1075..1099	CDD:404746
		C2H2 Zn finger	1077..1097	CDD:275368
		zf-H2C2_2	1089..1114	CDD:463886
		C2H2 Zn finger	1105..1126	CDD:275368