DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17568 and ZNF335

DIOPT Version :9

Sequence 1:	NP_609951.2	Gene:	CG17568 / 35198	FlyBaseID:	FBgn0032763	Length:	513	Species:	Drosophila melanogaster
Sequence 2:	NP_071378.1	Gene:	ZNF335 / 63925	HGNCID:	15807	Length:	1342	Species:	Homo sapiens

Alignment Length:	518	Identity:	112/518 - (21%)
Similarity:	173/518 - (33%)	Gaps:	176/518 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 ETDGDQEMDVAALRQQFGLCDDDWTHIIKPIPALEMESDNVYQKPAELLKDFPLAETSSQEMEIS 157
            |.:|.:|.|           |||   |:......::|.|:.| .|||       .|...:::.:.
Human   296 EEEGPEEED-----------DDD---IVDAGAIDDLEEDSDY-NPAE-------DEPRGRQLRLQ 338

  Fly   158 KRTTTTHLIQTKKNVEMEIPKQEFIDL-----GPILLEKNTSQLDMEDVLDELPQE--------- 208
            :.|.:|...:.:.....::|:.|..||     |..|:...:.|...|....|.|..
Human   339 RPTPSTPRPRRRPGRPRKLPRLEISDLPDGVEGEPLVSSQSGQSPPEPQDPEAPSSSGPGHLVAM 403

  Fly   209 -ELSQPRLDSTTSPASMENDVKSEMLDSCEGDDDFLPVDGQLMDLVAVATTPNTLESTAEEKAKR 272
             ::|:..:::..|.:..||     ...||..:.|.||                         .:|
Human   404 GKVSRTPVEAGVSQSDAEN-----AAPSCPDEHDTLP-------------------------RRR 438

  Fly   273 GRMDCEKCGKVYRNRASYEKHLERECRRIERRVKVDKTTTTCDICNKTLSSATALKLH------- 330
            ||......||.||      |:..:..:.:.|       ...|.||.....|...|:.|
Human   439 GRPSRRFLGKKYR------KYYYKSPKPLLR-------PFLCRICGSRFLSHEDLRFHVNSHEAG 490

  Fly   331 --------------------KEGI--HQNVKPYICDSCGKQLKTITALNEHKLVHTESR------ 367
                                ||.:  |...|||.||.|.........:..|..||:..|
Human   491 DPQLFKCLQCSYRSRRWSSLKEHMFNHVGSKPYKCDECSYTSVYRKDVIRHAAVHSRDRKKRPDP 555

  Fly   368 -----PFECTVCKAGFKNRARLKAHYQIHA-EPSFVCNICGKKLQTRRTWNMHKVVHTE---ERR 423
                 .|.|.||...:..:.||..|.:.|: |...:|:.|||..:.|.|:.||.:.|.:   .||
Human   556 TPKLSSFPCPVCGRVYPMQKRLTQHMKTHSTEKPHMCDKCGKSFKKRYTFKMHLLTHIQAVANRR 620

  Fly   424 LKCDVCGALFKRSKTLKTHLLSHTGLRPYVCNYC--------------------GKSFAC----- 463
            .||:.|..:.:..|.|..|.|||...:|:.|::|                    .|.|||
Human   621 FKCEFCEFVCEDKKALLNHQLSHVSDKPFKCSFCPYRTFREDFLLSHVAVKHTGAKPFACEYCHF 685

  Fly   464 ----NANCRSHKL-----------KKHPQEVQQEDGARLPSR----LNVPTLDELRVMTQKLP 507
                ..|.|.|..           ::||:|.        |||    .::..::||:......|
Human   686 STRHKKNLRLHVRCRHASSFEEWGRRHPEEP--------PSRRRPFFSLQQIEELKQQHSAAP 740

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17568	NP_609951.2	zf-AD	10..87	CDD:214871
		COG5048	<313..471	CDD:227381	57/230 (25%)
		C2H2 Zn finger	314..335	CDD:275368	8/49 (16%)
		C2H2 Zn finger	343..363	CDD:275368	4/19 (21%)
		C2H2 Zn finger	371..391	CDD:275368	6/19 (32%)
		C2H2 Zn finger	398..418	CDD:275368	8/19 (42%)
		C2H2 Zn finger	426..446	CDD:275368	6/19 (32%)
		zf-H2C2_2	439..463	CDD:290200	10/43 (23%)
		C2H2 Zn finger	454..475	CDD:275368	9/60 (15%)
ZNF335	NP_071378.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..102
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	201..228
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	274..442		39/197 (20%)
		C2H2 Zn finger	467..487	CDD:275368	6/19 (32%)
		C2H2 Zn finger	497..517	CDD:275368	2/19 (11%)
		zf-H2C2_2	509..534	CDD:290200	9/24 (38%)
		C2H2 Zn finger	529..545	CDD:275370	1/15 (7%)
		C2H2 Zn finger	564..584	CDD:275368	6/19 (32%)
		zf-H2C2_2	577..600	CDD:290200	8/22 (36%)
		zf-C2H2	590..612	CDD:278523	8/21 (38%)
		C2H2 Zn finger	592..612	CDD:275368	8/19 (42%)
		C2H2 Zn finger	623..643	CDD:275368	6/19 (32%)
		C2H2 Zn finger	651..672	CDD:275368	2/20 (10%)
		C2H2 Zn finger	680..699	CDD:275368	4/18 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	732..763		2/9 (22%)
		PRK04654	<795..911	CDD:135173
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	964..1013
		C2H2 Zn finger	1021..1041	CDD:275368
		Involved in the interaction with CCAR2. /evidence=ECO:0000269\|PubMed:19131338	1041..1342
		C2H2 Zn finger	1049..1069	CDD:275368
		zf-H2C2_5	1075..1097	CDD:290620
		C2H2 Zn finger	1077..1097	CDD:275368
		zf-H2C2_2	1089..1114	CDD:290200
		C2H2 Zn finger	1105..1126	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144310
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840