DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17568 and CG11695

DIOPT Version :9

Sequence 1:	NP_609951.2	Gene:	CG17568 / 35198	FlyBaseID:	FBgn0032763	Length:	513	Species:	Drosophila melanogaster
Sequence 2:	NP_572732.1	Gene:	CG11695 / 32106	FlyBaseID:	FBgn0030316	Length:	544	Species:	Drosophila melanogaster

Alignment Length:	578	Identity:	129/578 - (22%)
Similarity:	210/578 - (36%)	Gaps:	163/578 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 CRLCAKDDAHGNVKVQMNENSQGNW--DNVLIMAIRKYFEVQMQLEDELSSVLCTECYTLISELI 73
            ||||. |||..:|.: .:::..|:.  .:.|...|.|:.::.:...|.:|..|||:|:..:::..
  Fly     3 CRLCL-DDAEHSVPI-FDQDDSGDQPVPSNLAELIEKHLQLVLLPNDGVSKSLCTQCWQQLADFE 65

  Fly    74 DFAEHVTKVQDIFEVLRRTETDGDQEMDVAALRQQFGLCDDDWTHIIKPIPALEMESDNVYQKPA 138
            .|...|.|.|...:.|:......|::.|..|   |. ||:.:..  :.|..|...|.:.:.
  Fly    66 QFCAMVMKKQLGLQQLKMEPFSEDEDADTKA---QI-LCEPEID--VSPAAADNEECNEID---- 120

  Fly   139 ELLKDFPLAETSSQEMEISKRTTTTHLIQTKKNVEMEIPKQEFIDLGPILLEKNTSQLDMEDVLD 203
                    .:.||.....|.|||:..        ||.:|       .||   :...:|.....
  Fly   121 --------GDASSNSRSSSIRTTSLR--------EMRLP-------SPI---RRRMRLPRAVT-- 157

  Fly   204 ELPQEELSQPRLDSTTSPASMENDVKSEMLDSCEGDDDFLPVDGQLMDLVAVATTPNTLESTAEE 268
             .|:.:..:.:..:.|..|..:.|      :..||:.|                 |.:..|.:.|
  Fly   158 -APKTQAVKAKARTKTHKAEADED------EDAEGEGD-----------------PESRSSNSRE 198

  Fly   269 K----AKRGRMDCEKCG--KVYRNRASYEKHLERE---------C-RRIERR--------VKVDK 309
            .    |..||::|..||  :.:.|.|..::|....         | ||.::|        :..|.
  Fly   199 MDSYIALHGRLECCICGGDEQFPNFAEMKRHFRNHHQSLGYVVCCQRRYKKRALYVDHLHMHNDP 263

  Fly   310 TTTTCDICNKTLSSATALKLHKEGIHQNVK--PYICDSCGKQLKTITALNEHKLVHTESRPFECT 372
            ....|.||:|.|.|..:..:|....|.|..  .:.||.|.|:......|..|..||.:.|..:|.
  Fly   264 NYFRCKICSKQLVSRISYDVHMLRFHPNKDDLSFACDQCSKRFSKQFLLTIHSRVHQQERNEQCK 328

  Fly   373 VCKAGFKNRARLKAHYQIHAEPSFV---CNICGKKLQTRRTWNMHK-VVHTEE------------ 421
            .|...|:....|:.|.:...:|:||   |:.||.|.:|::...:|| .||.|.
  Fly   329 HCDRSFRTAVDLRLHMRRTHDPAFVPFICDSCGAKFKTKQNLLVHKRTVHREGSQLPEVQCQECQ 393

  Fly   422 ----------------------RRLKCDVCG----------------------------ALFKRS 436
                                  |:.||:.||                            ..||.|
  Fly   394 VWLSDENSLRKHMYMHLDAASLRQWKCEQCGLEKGSRAKLAAHIRYHHPKEYHKCTHCAKEFKSS 458

  Fly   437 KTLKTHLLSHTGLRPYVCNYCGKSFACNANCRSHKLKKHPQEVQQEDGARLPSRLNVP 494
            ::|:.|..:|||...|.|.:|.::|..:.|...|:.:.|..:|     |.|..:..||
  Fly   459 RSLEEHTATHTGQDLYECAFCERTFKNSGNMHKHRRQMHAAQV-----AALQQQKKVP 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17568	NP_609951.2	zf-AD	10..87	CDD:214871	22/77 (29%)
		COG5048	<313..471	CDD:227381	54/225 (24%)
		C2H2 Zn finger	314..335	CDD:275368	7/20 (35%)
		C2H2 Zn finger	343..363	CDD:275368	6/19 (32%)
		C2H2 Zn finger	371..391	CDD:275368	5/19 (26%)
		C2H2 Zn finger	398..418	CDD:275368	7/20 (35%)
		C2H2 Zn finger	426..446	CDD:275368	8/47 (17%)
		zf-H2C2_2	439..463	CDD:290200	9/23 (39%)
		C2H2 Zn finger	454..475	CDD:275368	5/20 (25%)
CG11695	NP_572732.1	zf-AD	2..81	CDD:285071	22/79 (28%)
		C2H2 Zn finger	268..289	CDD:275368	7/20 (35%)
		C2H2 Zn finger	299..319	CDD:275368	6/19 (32%)
		C2H2 Zn finger	327..348	CDD:275368	5/20 (25%)
		C2H2 Zn finger	357..376	CDD:275368	7/18 (39%)
		C2H2 Zn finger	389..409	CDD:275368	0/19 (0%)
		C2H2 Zn finger	420..440	CDD:275368	3/19 (16%)
		C2H2 Zn finger	448..468	CDD:275368	5/19 (26%)
		C2H2 Zn finger	476..494	CDD:275368	5/17 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24390
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010