Protein Alignment CG17568 and ZNF454

DIOPT Version :10

• Sequence 1: NP_609951.2
• Gene: CG17568 / 35198
• FlyBaseID: FBgn0032763
• Length: 513
• Species: Drosophila melanogaster
• Sequence 2: NP_872400.2
• Gene: ZNF454 / 285676
• HGNCID: 21200
• Length: 522
• Species: Homo sapiens
• Alignment Length: 377
• Identity: 103/377 - (27%)
• Similarity: 163/377 - (43%)
• Gaps: 61/377 - (16%)

  Fly   154 MEISKRTTTTHLIQTKKNVEMEIPKQEFIDLGP--------ILLEKNTSQLDM------EDVLDE 204
            |.:|...|......|.|:|.:...::|:..|.|        ::||..::.:.:      .|...:
Human     1 MAVSHLPTMVQESVTFKDVAILFTQEEWGQLSPAQRALYRDVMLENYSNLVSLGLLGPKPDTFSQ 65

  Fly   205 LPQEELSQPR-------LDSTTSPASMENDVKSEM----LDSCEGDDDF-------------LPV 245
            |.:.|:..|.       ||..|.|||.::.||:|:    ||.....:.|             ...
Human    66 LEKREVWMPEDTPGGFCLDWMTMPASKKSTVKAEIPEEELDQWTIKERFSSSSHWKCASLLEWQC 130

  Fly   246 DGQLMDLVAVATT-PNTLESTAEE-----------------KAKRGRMDCEKCGKVYRNRASYEK 292
            .||.:.|..|..| |||.....:|                 :..:...:|.:||||:...::..|
Human   131 GGQEISLQRVVLTHPNTPSQECDESGSTMSSSLHSDQSQGFQPSKNAFECSECGKVFSKSSTLNK 195

  Fly   293 H--LERECRRIERRVKVDKTTTTCDICNKTLSSATALKLHKEGIHQNVKPYICDSCGKQLKTITA 355
            |  :..| :...:::.:.:....|..|.|....:|.| :|.:.||...|||.|..|||.....::
Human   196 HQKIHNE-KNANQKIHIKEKRYECRECGKAFHQSTHL-IHHQRIHTGEKPYECKECGKAFSVSSS 258

  Fly   356 LNEHKLVHTESRPFECTVCKAGFKNRARLKAHYQIH-AEPSFVCNICGKKLQTRRTWNMHKVVHT 419
            |..|:.:||..:||||.:|...|.....|..|::|| .|..|.||||.|....|.....|:.:|:
Human   259 LTYHQKIHTGEKPFECNLCGKAFIRNIHLAHHHRIHTGEKPFKCNICEKAFVCRAHLTKHQNIHS 323

  Fly   420 EERRLKCDVCGALFKRSKTLKTHLLSHTGLRPYVCNYCGKSFACNANCRSHK 471
            .|:..||:.||..|.:|.:...|...|||.:|:.||.|||:|..|::...|:
Human   324 GEKPYKCNECGKAFNQSTSFLQHQRIHTGEKPFECNECGKAFRVNSSLTEHQ 375

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG17568	NP_609951.2	zf-AD	10..87	CDD:214871
		COG5048	<313..471	CDD:227381	58/158 (37%)
		C2H2 Zn finger	314..335	CDD:275368	6/20 (30%)
		C2H2 Zn finger	343..363	CDD:275368	6/19 (32%)
		C2H2 Zn finger	371..391	CDD:275368	5/19 (26%)
		C2H2 Zn finger	398..418	CDD:275368	7/19 (37%)
		C2H2 Zn finger	426..446	CDD:275368	6/19 (32%)
		C2H2 Zn finger	454..475	CDD:275368	8/18 (44%)
ZNF454	NP_872400.2	KRAB	14..73	CDD:214630	11/58 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	147..170		2/22 (9%)
		C2H2 Zn finger	180..200	CDD:275368	7/19 (37%)
		COG5048	186..522	CDD:227381	63/192 (33%)
		C2H2 Zn finger	218..238	CDD:275368	6/20 (30%)
		C2H2 Zn finger	246..266	CDD:275368	6/19 (32%)
		C2H2 Zn finger	274..294	CDD:275368	5/19 (26%)
		C2H2 Zn finger	302..322	CDD:275368	7/19 (37%)
		C2H2 Zn finger	330..350	CDD:275368	6/19 (32%)
		C2H2 Zn finger	358..378	CDD:275368	8/18 (44%)
		C2H2 Zn finger	386..406	CDD:275368
		C2H2 Zn finger	414..434	CDD:275368
		C2H2 Zn finger	442..462	CDD:275368
		C2H2 Zn finger	470..490	CDD:275368
		C2H2 Zn finger	498..518	CDD:275368