DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17568 and ace2

DIOPT Version :9

Sequence 1:	NP_609951.2	Gene:	CG17568 / 35198	FlyBaseID:	FBgn0032763	Length:	513	Species:	Drosophila melanogaster
Sequence 2:	NP_594109.1	Gene:	ace2 / 2541661	PomBaseID:	SPAC6G10.12c	Length:	533	Species:	Schizosaccharomyces pombe

Alignment Length:	483	Identity:	102/483 - (21%)
Similarity:	165/483 - (34%)	Gaps:	158/483 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 DWTHIIK-PIPALEMESDNVYQKPAELLKDFPLAETSSQEMEISKRT---TTTHLIQTKKN---- 171
            |::.::| |...| :|:::.|....::......:..||.:..:|..:   |....|.|::|
pombe    76 DYSSVLKTPFNPL-LEANSAYFLSNQISLPDSHSYASSFDASLSPPSSPLTCVSQIHTEQNFNNN 139

  Fly   172 --VEMEIPKQEFIDLGPILLEKNTSQLDMEDVLDEL--PQEELSQPRLD---------------- 216
              ..:...:|.|.::|          .|..:.:|||  .|:.||.|..|
pombe   140 DAFSLTNSQQAFSEIG----------YDASNWIDELDSQQQVLSFPEFDIPEIKTETCSNKDHLE 194

  Fly   217 ----------STTSPASMENDVKSEM---------------LDSCEGDDDFLPVDGQL------- 249
                      .|:.|||......|::               ||...|...|..::.|:
pombe   195 NFDYLSSSIPETSGPASSVLPSSSQLESFNEFMFLPSSPPGLDEINGAPSFEELNFQISQPSPAH 259

  Fly   250 -MDLVAVATTPN-----------TLESTAEEKAKRGRMDCEKCGKVYRNRASYEKHLERECRRIE 302
             :||.:..|.||           .||.|:.:|..            :...:|: .||: .||..:
pombe   260 PVDLSSPETAPNISPVSPFAQLVKLEPTSPQKPS------------FALDSSF-SHLD-VCRHTD 310

  Fly   303 RR-------------VKVDKTTTTCD--------ICNKTLSSATALKLHKEGIHQNVKPYICDSC 346
            .:             .:.:|.::.||        ..|.||:...||....|......||..|.:.
pombe   311 NQKAFAKLSSPAEYVSEFEKFSSVCDHGLDISNANINNTLTQQFALSAPYESCIVTKKPEPCITV 375

  Fly   347 GKQ-----------LKTITALNEHKLVHTESRP-------FEC-------TVCKAGFKNRARLKA 386
            .::           |.....:.||     :|:|       ..|       .:|:...:..|.|
pombe   376 KEEEQLAPKIESADLSITPQVTEH-----DSKPPVRISYDHRCKTRKQSTRICRIPPETMASL-- 433

  Fly   387 HYQIHAEPSFVC--NICGKKLQTRRTWNMHKVVHTEERRLKCDVCGALFKRSKTLKTHLLSHTGL 449
            :....|:..:||  |.|.|::..:.....|...|..:|..:||:|.|.|.|...||.||..|...
pombe   434 YCGPEADGKYVCLYNGCNKRIARKYNVESHIQTHLSDRPYRCDLCKAGFVRHHDLKRHLRIHENG 498

  Fly   450 RPYVCNYCGKSFACNANCRSHKLKKHPQ 477
            |||||. |.|.|.     |...|.:|.|
pombe   499 RPYVCE-CLKRFN-----RLDALNRHKQ 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17568	NP_609951.2	zf-AD	10..87	CDD:214871
		COG5048	<313..471	CDD:227381	49/192 (26%)
		C2H2 Zn finger	314..335	CDD:275368	8/28 (29%)
		C2H2 Zn finger	343..363	CDD:275368	4/30 (13%)
		C2H2 Zn finger	371..391	CDD:275368	4/26 (15%)
		C2H2 Zn finger	398..418	CDD:275368	5/21 (24%)
		C2H2 Zn finger	426..446	CDD:275368	10/19 (53%)
		zf-H2C2_2	439..463	CDD:290200	13/23 (57%)
		C2H2 Zn finger	454..475	CDD:275368	6/20 (30%)
ace2	NP_594109.1	COG5048	45..518	CDD:227381	100/479 (21%)
		C2H2 Zn finger	448..467	CDD:275368	4/18 (22%)
		zf-C2H2	473..495	CDD:278523	10/21 (48%)
		C2H2 Zn finger	475..495	CDD:275368	10/19 (53%)
		zf-H2C2_2	487..511	CDD:290200	13/29 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	84	1.000	Inparanoid score	I1804
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050