DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment brat and TRIM56

DIOPT Version :9

Sequence 1:	NP_001188842.2	Gene:	brat / 35197	FlyBaseID:	FBgn0010300	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	NP_112223.1	Gene:	TRIM56 / 81844	HGNCID:	19028	Length:	755	Species:	Homo sapiens

Alignment Length:	856	Identity:	155/856 - (18%)
Similarity:	262/856 - (30%)	Gaps:	296/856 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   177 PRCTAC-----KSKCSDAVAKCFECQSYLCANCVTAHEFMHCFNGHNVCLIKGFEASTTGTPLSV 236
            |.|..|     .|....|.|:|.:|...||..|...|......:.|.|..:.|:.|.
Human    99 PACALCPLVGGTSTGGPATARCLDCADDLCQACADGHRCTRQTHTHRVVDLVGYRAG-------- 155

  Fly   237 GSPSNNPASNEFKYASSLTMMLQQQQQLDSQQQQQQQQLLPAQPMSQLSKIVLAAAAQANSQEQQ 301
                                      ..|.:.:::|                   |||
Human   156 --------------------------WYDEEARERQ-------------------AAQ------- 168

  Fly   302 REDSIYGSLHPQQQQQQQQQQQRQLFCPRHKQELLKFSCRTCCILVCKECIVLEHSTGLHELENV 366
                                      ||:|..|.|:|.|:.|..|:|:||.:..|         :
Human   169 --------------------------CPQHPGEALRFLCQPCSQLLCRECRLDPH---------L 198

  Fly   367 QSPGMTTSTGSTANESALQTLLADMRGKIGEIVGIAGNSDQNLTKVKLQYQKAHNELNETHQFFA 431
            ..|.:..:....|....|:.|||.:...:.|:........:.|.:::.|..:...::.|..:...
Human   199 DHPCLPLAEAVRARRPGLEGLLAGVDNNLVELEAARRVEKEALARLREQAARVGTQVEEAAEGVL 263

  Fly   432 SMLDERKTELLKELETLYTAKVNSNNSWQQRSRDLIDKGLATCEAVERSPAPPS----SLLTEAL 492
            ..|..:|.|:|.:|.....|   :..:.::|..:|..:     |.|.|:.|..:    ||..||.
Human   264 RALLAQKQEVLGQLRAHVEA---AEEAARERLAELEGR-----EQVARAAAAFARRVLSLGREAE 320

  Fly   493 LLRKSLEQQLQTGIQEMQ------------LPFEIEF---------------MSNYQSIQAGVRN 530
            :|  |||..:...::::|            || ::|.               ....|..:.|.::
Human   321 IL--SLEGAIAQRLRQLQGCPWAPGPAPCLLP-QLELHPGLLDKNCHLLRLSFEEQQPQKDGGKD 382

  Fly   531 TFGYIRANSSDGGPTGMSLTSN--------------GHGKQPPIARPTQSASNSSASS-----AG 576
            ..|      :.||....|...:              |.|.|.|.....|:.....|.:     |.
Human   383 GAG------TQGGEESQSRREDEPKTERQGGVQPQAGDGAQTPKEEKAQTTREEGAQTLEEDRAQ 441

  Fly   577 SGHHGHHQQSHHHGHHNHHQ--TAHHQQLQAQSSLHGLGLGLSGASLL---------------DS 624
            :.|.....|.|..|..|..:  ....:.:..:.| ..||..|.|:.||               |.
Human   442 TPHEDGGPQPHRGGRPNKKKKFKGRLKSISREPS-PALGPNLDGSGLLPRPIFYCSFPTRMPGDK 505

  Fly   625 SSSAGGAVGAFSNGGLLLGGRDRNALAVEQHFGELMPKRG--GGGYTGSNGSATSAVAHYNPYEK 687
            .|.....:..|....:|:......||           ||.  .|.|.|:
Human   506 RSPRITGLCPFGPREILVADEQNRAL-----------KRFSLNGDYKGT---------------- 543

  Fly   688 WSNGGSDNLFSSVTSGVSGSSAVADAFASLSAVGGSVVSGAGAGGSTVSSESLLDLTNKLLSATI 752
                      ..|..|.|.        .|::|:..:|...|                    ||.:
Human   544 ----------VPVPEGCSP--------CSVAALQSAVAFSA--------------------SARL 570

  Fly   753 Y--PPKSQIKRQKMIYHCKFGEFGVMEGQFTEPS-GVAVNAQNDIIVADTNNHRIQIFDKEGRFK 814
            |  .|..:::.::.:             ..::.| .||.....|.:......| :::::.||...
Human   571 YLINPNGEVQWRRAL-------------SLSQASHAVAALPSGDRVAVSVAGH-VEVYNMEGSLA 621

  Fly   815 FQFGECGKRDSQLLYPNRVAVVRNSGDIIVTERSP----------THQIQIYNQYGQFVRKFGAT 869
            .:|...||..            |....::....||          .:.:.|.:..||.|.::...
Human   622 TRFIPGGKAS------------RGLRALVFLTTSPQGHFVGSDWQQNSVVICDGLGQVVGEYKGP 674

  Fly   870 ILQ--HPRGVTVDNKGRIIVVECKVMRVIIFDQNGNVLHKFGCSKH-LEFPNGVVVNDKQEIFI- 930
            .|.  .|..|:||.||.|.:...:|.:|:|.|..|::|..|..:.| ||.|....:.|.:.:.:
Human   675 GLHGCQPGSVSVDKKGYIFLTLREVNKVVILDPKGSLLGDFLTAYHGLEKPRVTTMVDGRYLVVS 739

  Fly   931 -SDNRAHCVKV 940
             |:...|..:|
Human   740 LSNGTIHIFRV 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brat	NP_001188842.2	BBOX	176..222	CDD:197662	14/49 (29%)
		zf-B_box	328..366	CDD:279037	13/37 (35%)
		NHL_brat_like	760..1030	CDD:271329	40/197 (20%)
		NHL repeat	783..819	CDD:271329	8/36 (22%)
		NHL repeat	830..871	CDD:271329	7/50 (14%)
		NHL repeat	874..910	CDD:271329	14/35 (40%)
		NHL repeat	914..954	CDD:271329	7/29 (24%)
		NHL repeat	959..997	CDD:271329
		NHL repeat	1002..1027	CDD:271329
TRIM56	NP_112223.1	RAD18	8..>214	CDD:333230	36/209 (17%)
		RING-HC_TRIM56_C-V	19..60	CDD:319498
		RING-HC finger (C3HC4-type)	21..59	CDD:319498
		BBOX	169..205	CDD:237988	14/44 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	371..484		22/119 (18%)
		NHL	521..748	CDD:302697	58/317 (18%)
		WD40 repeat	593..627	CDD:293791	7/34 (21%)
		NHL repeat	598..626	CDD:271320	5/28 (18%)
		NHL repeat	634..674	CDD:271320	6/39 (15%)
		WD40 repeat	635..672	CDD:293791	6/36 (17%)
		WD40 repeat	681..720	CDD:293791	14/38 (37%)
		NHL repeat	681..714	CDD:271320	13/32 (41%)
		NHL repeat	723..748	CDD:271320	5/24 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489543at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010