DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment brat and Trim2

DIOPT Version :9

Sequence 1:	NP_001188842.2	Gene:	brat / 35197	FlyBaseID:	FBgn0010300	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	XP_011238598.1	Gene:	Trim2 / 80890	MGIID:	1933163	Length:	774	Species:	Mus musculus

Alignment Length:	914	Identity:	211/914 - (23%)
Similarity:	353/914 - (38%)	Gaps:	249/914 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   179 CTACKSKCSDAVAKCFECQSYLCANC----VTAHEF-MHCFNGHNVCLIKGFEASTTGTP-LSVG 237
            |:.|..:..:  .|...|....|..|    :.||.. :.|    .||      ..|:..| ..|.
Mouse    49 CSICLERYKN--PKVLPCLHTFCERCLQNYIPAHSLTLSC----PVC------RQTSILPEKGVA 101

  Fly   238 SPSNNPASNEFKYASSLTMMLQQQQQLDSQQQQQQQQLLPAQPMSQLSKIVLAAAAQANSQEQQR 302
            :..||      .:.::|..:||:....:.:.             |.:.:.|.|.||
Mouse   102 ALQNN------FFITNLMDVLQRTPGSNGED-------------SSILETVTAVAA--------- 138

  Fly   303 EDSIYGSLHPQQQQQQQQQQQRQLFCPRHKQELLKFSCRTCCILVCKECIVLEHSTGLHELENVQ 367
                                .:.|.||.|...:::|.|::|...:|:||...||:         :
Mouse   139 --------------------GKPLSCPNHDGNVMEFYCQSCETAMCRECTEGEHA---------E 174

  Fly   368 SPGMTTSTGSTANESALQTLLADMRGKIGEIVGIAGNSDQNLTKV--KLQYQKAH--NELNETHQ 428
            .|.:........::::||..|..:..::.||    .::.|.::::  :|..|||.  ::::.|..
Mouse   175 HPTVPLKDVVEQHKASLQVQLDAVNKRLPEI----DSALQFISEIIHQLTNQKASIVDDIHSTFD 235

  Fly   429 FFASMLDERKTELLKELETLYTAKVNSNNSWQQRSRDLIDKGLATCEAVER--SPAPPSSLLTEA 491
            .....|:.||:.||.|||..|..|    :...|...|.:.:|..:.::...  :.|......||.
Mouse   236 ELQKTLNVRKSVLLMELEVNYGLK----HKVLQSQLDTLLQGQESIKSCSNFTAQALNHGTETEV 296

  Fly   492 LLLRKSLEQQLQTGIQEMQLPF------EIEFMSNYQSIQAGVRNTFGYIRAN--SSDGGPTGMS 548
            ||::|.:.::|.. :.:...|.      :::|:...:.::..:.|....:..|  :|:...||..
Mouse   297 LLVKKQMSEKLNE-LADQDFPLHPRENDQLDFIVETEGLKKSIHNLGTILTTNAVASETVATGEG 360

  Fly   549 LTSNGHGKQPPIARP---TQSASNSSASSAGSGHHGHHQQSHHHGHHNHHQTAHHQQLQAQSSLH 610
            |      :|..|.:|   |.:..:.......:|              |.:.||.
Mouse   361 L------RQTIIGQPMSVTITTKDKDGELCKTG--------------NAYLTAE----------- 394

  Fly   611 GLGLGLSGASLLDSSSSAGGAVGAFSNGGLLLGGRDRNALAVEQHFGELMPKRGGGG---YT-GS 671
               |.....|:.|                                 ||::..:.|..   || ..
Mouse   395 ---LSTPDGSVAD---------------------------------GEILDNKNGTYEFLYTVQK 423

  Fly   672 NGSATSAVAHYNPYEKWSNGGSDNLFSSVTSGVSGSSAVADAFASLSAVGGSVVSGAGAGGSTVS 736
            .|..|.::..|:.:.:    ||......:.|        ||...:...|...|.| .|:|
Mouse   424 EGDFTLSLRLYDQHIR----GSPFKLKVIRS--------ADVSPTTEGVKRRVKS-PGSG----- 470

  Fly   737 SESLLDLTNKLLSATIYPPKSQIKRQKMIYHC--------------KFGEFGVMEGQFTEPSGVA 787
                            :..:..:||...:|..              :.|..|..:|:||...|||
Mouse   471 ----------------HVKQKAVKRPASMYSTGKRKENPIEDDLIFRVGTKGRNKGEFTNLQGVA 519

  Fly   788 VNAQNDIIVADTNNHRIQIFDKEGRFKFQFGECGKRDSQLLYPNRVAVVRNSGDIIVTERSPTHQ 852
            .:....|::||:||..:|||..:|:||.:||..|:...||..|..|| |..|||||:.:.. ...
Mouse   520 ASTSGKILIADSNNQCVQIFSNDGQFKSRFGIRGRSPGQLQRPTGVA-VHPSGDIIIADYD-NKW 582

  Fly   853 IQIYNQYGQFVRKFGATILQHPRGVTVDNKGRIIVVECKVMRVIIFDQNGNVLHKFGCSKH---- 913
            :.|::..|:|..|.|:..|..|:||:||..|.||||:.|...|.||..||.::.:||...:
Mouse   583 VSIFSNDGKFKTKIGSGKLMGPKGVSVDRNGHIIVVDNKACCVFIFQPNGKIVTRFGSRGNGDRQ 647

  Fly   914 ----LEFPNGVVVNDKQEIFISDNRAHCVKVFNYEGQYLRQIG----GEGITNYPIGVGINSNGE 970
                |:.|:...||...||.|:|...|.|||||.||:::.:.|    |.|..|.|.||.::|||.
Mouse   648 FAGTLDGPHFAAVNSNNEIIITDFHNHSVKVFNQEGEFMLKFGSNGEGNGQFNAPTGVAVDSNGN 712

  Fly   971 ILIADNHNNFNLTIFTQDGQLISALESKVKHAQCFD-------VALMDDGSVVLA-SKDYRLYIY 1027
            |::|| ..|..:.:|...|..:|.:.:..      |       :||..||.||:| |.::...:|
Mouse   713 IIVAD-WGNSRIQVFDGSGSFLSYINTSA------DPLYGPQGLALTSDGHVVVADSGNHCFKVY 770

  Fly  1028 RYVQ 1031
            ||:|
Mouse   771 RYLQ 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brat	NP_001188842.2	BBOX	176..222	CDD:197662	11/47 (23%)
		zf-B_box	328..366	CDD:279037	11/37 (30%)
		NHL_brat_like	760..1030	CDD:271329	104/303 (34%)
		NHL repeat	783..819	CDD:271329	15/35 (43%)
		NHL repeat	830..871	CDD:271329	14/40 (35%)
		NHL repeat	874..910	CDD:271329	17/35 (49%)
		NHL repeat	914..954	CDD:271329	17/43 (40%)
		NHL repeat	959..997	CDD:271329	13/37 (35%)
		NHL repeat	1002..1027	CDD:271329	9/32 (28%)
Trim2	XP_011238598.1	RING-HC_TRIM2	46..91	CDD:319681	11/53 (21%)
		Bbox2_TRIM2_C-VII	141..182	CDD:380882	13/49 (27%)
		BBC	187..313	CDD:128778	31/134 (23%)
		IG_FLMN	351..447	CDD:214720	25/166 (15%)
		NHL_TRIM2_like	497..774	CDD:271330	102/285 (36%)
		NHL repeat	515..554	CDD:271330	16/38 (42%)
		NHL repeat	562..601	CDD:271330	14/40 (35%)
		NHL repeat	604..640	CDD:271330	17/35 (49%)
		NHL repeat	648..692	CDD:271330	17/43 (40%)
		NHL repeat	701..741	CDD:271330	13/46 (28%)
		NHL repeat	744..770	CDD:271330	8/25 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D133242at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24104
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2677
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.050