DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment brat and ftr85

DIOPT Version :9

Sequence 1:	NP_001188842.2	Gene:	brat / 35197	FlyBaseID:	FBgn0010300	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	XP_698105.5	Gene:	ftr85 / 569616	ZFINID:	ZDB-GENE-070705-22	Length:	475	Species:	Danio rerio

Alignment Length:	445	Identity:	87/445 - (19%)
Similarity:	155/445 - (34%)	Gaps:	118/445 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   194 FECQSYLCANCVTAHEFMHCFNGHNVCL--IKGF-----EASTTGTPLSVGSPSNNPASNEFKYA 251
            |.|.  :|.:.:.....:.|  |||.|:  ||.|     :......|....|.:..||.|:
Zfish    15 FSCP--ICMDLLRDPVTIPC--GHNYCMECIKSFWEQKSQRKLCSCPECRQSFNPRPALNK---- 71

  Fly   252 SSLTMMLQQQQQLDSQQQQQQQQLLPAQPMSQLSKIVLAAAAQANSQEQQREDSIYGSLHPQQQQ 316
              .|:..:..:::  :....:...|||           ||.|:.:      :|::...|..:..:
Zfish    72 --NTLFAEVVEKM--RHTGTRSPTLPA-----------AAGAKGD------QDTVGEKLCEKLCE 115

  Fly   317 QQQQQQQRQLFCPRHKQELLKFSCRTCCILVCKECIVLEHSTGLHELENVQSPGMTTSTGSTANE 381
            |:.:|.||:                      |:: ::.:..|.|.:|.  |:..:..|:...|.|
Zfish   116 QELKQSQRR----------------------CQQ-VIRQRETELQDLS--QAVILLRSSAQEAVE 155

  Fly   382 SALQTLLADMRGKIGEIVGIAGNSDQNLTKVKLQYQKAHNELNETHQFFASMLD----------- 435
             |.:.:.:::      ::.|.....:....:|   :|...||:|:|.|...:..
Zfish   156 -ATEKIFSEL------VLSIEALCFEVTEMIK---EKEQAELDESHGFMEKLEQEIAEFKRRDAE 210

  Fly   436 -------ERKTELLKELETLYT---------AKVNSNNSWQQRSR----------DLIDKGLA-T 473
                   |.||:.||..|||.:         ..||.:..::..:|          ||..|.|. .
Zfish   211 YDRLAQLEDKTQFLKGYETLCSLPELLTSPAVLVNPDFCFEMVARKLTYLNEEIKDLCQKKLVKL 275

  Fly   474 CEAVER---SPAPPSSLLTEALLLRKSLEQQLQTGIQEMQL-PFEIE--FMSNYQSIQAGVRNTF 532
            .:.|.|   .|.|...:..:.|.....|...|.|..:.:.: |..::  |...|.|:........
Zfish   276 SKKVTRLKFIPTPEPKVREQFLEYSGPLTLDLNTAHKNLIICPDNVQATFSKTYLSVPDHPERFD 340

  Fly   533 GYIRANSSDGGPTGMSLTSNGHGKQP-PIARPTQSASNSSASSAGSGHHGHHQQS 586
            ||.:....:.........:...||.| .||...:..|....||..:  .||:.||
Zfish   341 GYYQVLCRESVSGRCYFETEWSGKGPVHIAVSYEDISRKGKSSQCA--FGHNAQS 393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brat	NP_001188842.2	BBOX	176..222	CDD:197662	8/29 (28%)
		zf-B_box	328..366	CDD:279037	4/37 (11%)
		NHL_brat_like	760..1030	CDD:271329
		NHL repeat	783..819	CDD:271329
		NHL repeat	830..871	CDD:271329
		NHL repeat	874..910	CDD:271329
		NHL repeat	914..954	CDD:271329
		NHL repeat	959..997	CDD:271329
		NHL repeat	1002..1027	CDD:271329
ftr85	XP_698105.5	zf-C3HC4_4	17..59	CDD:291880	11/45 (24%)
ftr85	XP_698105.5	SPRY_PRY_SNTX	293..472	CDD:294002	22/103 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2677
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.030