DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment brat and trim3a

DIOPT Version :9

Sequence 1:	NP_001188842.2	Gene:	brat / 35197	FlyBaseID:	FBgn0010300	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	XP_686295.4	Gene:	trim3a / 562489	ZFINID:	ZDB-GENE-080522-4	Length:	774	Species:	Danio rerio

Alignment Length:	774	Identity:	197/774 - (25%)
Similarity:	306/774 - (39%)	Gaps:	188/774 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   326 LFCPRHKQELLKFSCRTCCILVCKECIVLEHSTGLHELENVQSPGMTTSTGSTANESALQTLLAD 390
            |.||.|:.::::|.|.:|...:|.||...||.      |:|..|   .......:::||:..|..
Zfish   121 LSCPNHEGKVMEFYCESCETAMCLECTEGEHR------EHVTVP---LRDVLEQHKAALKNQLDA 176

  Fly   391 MRGKIGEI---VGIAGNSDQNLTKVKLQYQKAHNELNETHQFFASMLDERKTELLKELETLYTAK 452
            :|.::.::   :.:.....:.||..|   .:|..|::.|.:.....|.:|||.|:.:||.:.:.|
Zfish   177 IRNRLPQLTAAIELVNEISKQLTDRK---NEAVTEISNTFEELEKALHQRKTTLITDLENICSTK 238

  Fly   453 VNSNNSWQQRSRDLIDKGLATCEAVERSPAPPSSLLTEALLLRKSLEQQLQTGIQEMQLPFEIEF 517
                                                      :|.|:.||..            .
Zfish   239 ------------------------------------------QKVLQGQLAA------------L 249

  Fly   518 MSNYQSIQAGVRNTFGYIRANSSDGGPTGMSLTSNGHG-KQPPIARPTQSASNSSASSAGSGHHG 581
            |...::||    ::..:.....:.|.||.:.|.....| :...:||                 |.
Zfish   250 MQGKENIQ----SSCSFTEQALNHGSPTEVLLVQKQMGERMGALAR-----------------HA 293

  Fly   582 HHQQSHHHGHHNHHQTAHHQQLQAQSSLHGLGLGLSGASLLDSSSSAGGAVGAFSNG--GLLLGG 644
            ..:|.|.:||           |..|....||...:....:|.::||.|....|...|  ..::|.
Zfish   294 FPEQPHENGH-----------LDCQVETEGLRRSIQNLGVLLTTSSVGHTSVATGEGLRHAVVGQ 347

  Fly   645 RDRNALAVEQHFGELMPKRGGGG----YTGSNGSATSAVAHYNP-------YEKWSNGGSDNLFS 698
            .....:..:...|||: |.|...    .:|::|..|......|.       |...|.|  :..||
Zfish   348 NTTVTVTTKDKDGELV-KTGNAALRAQISGADGGVTETDVTDNKNGTYEIGYTLRSEG--EFSFS 409

  Fly   699 SVTSG--VSGSS------AVADAFASLSAVGGSVVS---GAGAGG----STVSSESLLDLTNKLL 748
            .:..|  |.||.      ...||..|...|...|.|   |.||||    ..|...|.:..|.|
Zfish   410 VLLYGRHVRGSPFRLRAVKACDAPQSPDDVKRRVKSPGGGGGAGGHVRQKAVRRPSSMYSTTK-- 472

  Fly   749 SATIYPPKSQIKRQKMIYHCKFGEFGVMEGQFTEPSGVAVNAQNDIIVADTNNHRIQIFDKEGRF 813
                  .|......::|:  :.|..|...|:|:...|::..:...|:|||:||..||:|..:|:|
Zfish   473 ------KKENPIEDELIF--RVGTRGRERGEFSNLQGISTTSSGRIVVADSNNQCIQVFSNDGQF 529

  Fly   814 KFQFGECGKRDSQLLYPNRVAVVRNSGDIIVTERSPTHQIQIYNQYGQFVRKFGATILQHPRGVT 878
            |.:||..|:...||..|..|||..| |||||.:.. ...:.|::..|:|..|.||..|..|:||.
Zfish   530 KLKFGVRGRSPGQLQRPTGVAVDMN-GDIIVADYD-NRWLSIFSPDGKFKNKIGAGRLMGPKGVA 592

  Fly   879 VDNKGRIIVVECKVMRVIIFDQNGNVLHKFGC--SKHLEF----------------------PNG 919
            ||..|.||..:.|...|.||..||.::.|||.  :...:|                      |:.
Zfish   593 VDKNGHIITADNKACCVFIFQSNGKLVTKFGAKGTSERQFADKSAPNTPTEPKQSKSGPAFSPHF 657

  Fly   920 VVVNDKQEIFISDNRAHCVKVFNYEGQYLRQIG----GEGITNYPIGVGINSNGEILIADNHNNF 980
            |.:|:|.||.::|...|.|||:|.:|::|.:.|    |.|..|.|.||.::.||.|::|| ..|.
Zfish   658 VAINNKNEIVVTDFHNHSVKVYNADGEFLFKFGSHGEGNGQFNAPTGVAVDGNGNIIVAD-WGNS 721

  Fly   981 NLTIFTQDGQLISALESKVKHAQCFD-------VALMDDGSVVLA-SKDYRLYIYRYVQ 1031
            .:.:|...|..:|.:.:..      |       :||..||.|.:| |.::...:|||:|
Zfish   722 RIQVFDSSGSFLSYINTTA------DPLYGPQGLALTSDGHVAVADSGNHCFKVYRYLQ 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brat	NP_001188842.2	BBOX	176..222	CDD:197662
		zf-B_box	328..366	CDD:279037	12/37 (32%)
		NHL_brat_like	760..1030	CDD:271329	98/305 (32%)
		NHL repeat	783..819	CDD:271329	14/35 (40%)
		NHL repeat	830..871	CDD:271329	16/40 (40%)
		NHL repeat	874..910	CDD:271329	16/35 (46%)
		NHL repeat	914..954	CDD:271329	16/65 (25%)
		NHL repeat	959..997	CDD:271329	12/37 (32%)
		NHL repeat	1002..1027	CDD:271329	8/32 (25%)
trim3a	XP_686295.4	RING	27..70	CDD:238093
		BBOX	118..159	CDD:197662	15/46 (33%)
		BBC	166..291	CDD:128778	30/185 (16%)
		IG_FLMN	333..429	CDD:214720	21/98 (21%)
		Filamin	333..423	CDD:279024	21/92 (23%)
		NHL_TRIM2_like	481..774	CDD:271330	99/303 (33%)
		YncE	496..>765	CDD:225926	92/277 (33%)
		NHL repeat	499..538	CDD:271330	15/38 (39%)
		NHL repeat	546..585	CDD:271330	16/40 (40%)
		NHL repeat	588..625	CDD:271330	17/36 (47%)
		NHL repeat	632..693	CDD:271330	16/60 (27%)
		NHL repeat	699..741	CDD:271330	13/48 (27%)
		NHL repeat	744..770	CDD:271330	7/25 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D133242at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24104
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	4.020