DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment brat and trim3b

DIOPT Version :9

Sequence 1:	NP_001188842.2	Gene:	brat / 35197	FlyBaseID:	FBgn0010300	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	XP_005155434.1	Gene:	trim3b / 555391	ZFINID:	ZDB-GENE-070112-1132	Length:	772	Species:	Danio rerio

Alignment Length:	783	Identity:	202/783 - (25%)
Similarity:	321/783 - (40%)	Gaps:	204/783 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   324 RQLFCPRHKQELLKFSCRTCCILVCKECIVLEHSTGLHELENVQSPGMTTSTGSTANESALQTLL 388
            :.|.||.|:.::::|.|.:|...:|.||...||.      |:|..|   .......:::.|:..|
Zfish   119 KPLSCPNHEGKVMEFYCESCETAMCLECTEGEHR------EHVTVP---LRDVLEQHKAVLKNQL 174

  Fly   389 ADMRGKIGEI---VGIAGNSDQNLTKVKLQYQKAHNELNETHQFFASMLDERKTELLKELETLYT 450
            ..:|.::.::   :.:.....:.||:.|   .:|.||:|.|.:.....|.:||..|:.:||.:.:
Zfish   175 DAIRNRLPQLTAAIEMVNEISKQLTERK---NEAVNEINMTFEELERALHQRKAALITDLENICS 236

  Fly   451 AK---VNSNNSWQQRSRDLIDKGLATCEAVERSPAPPSSLLTEALLLRKSLEQQLQTGIQEMQLP 512
            .|   :.:..|...:.::.|.   ::|...|::.:..|:  ||.||::|.:.:::.
Zfish   237 TKQKVLQAQLSSLLQGKEHIQ---SSCSFTEQALSHGSA--TEVLLVQKQMSERVS--------- 287

  Fly   513 FEIEFMSNYQSIQAGVRNTFGYIRANSSDGGPTGMSLTSNGHGKQPPIARPTQSASNSSASSAGS 577
                                               :|..:...::|
Zfish   288 -----------------------------------ALACHDFPERP------------------- 298

  Fly   578 GHHGHHQQSHHHGHHNHHQTAHHQQLQAQSSLHGLGLGLSGASLLDSSSSAGGAVGAFSNGGLLL 642
                             |:.||   |..|....||...:....:|.::    ||||..|   :..
Zfish   299 -----------------HENAH---LDCQIETEGLRRSIQNLGVLLTT----GAVGHTS---VAT 336

  Fly   643 GGRDRNALAVEQHF----------GELMPKRGGG--------GYTGSNGSATSAVAHYN-PYE-- 686
            |...|:|| |.||.          .||:  |.|.        |..|:..:....|.:.| .||
Zfish   337 GEGLRHAL-VGQHVTVTVTTKDKDSELV--RTGNAALRAEIMGQDGAQVTEAEVVDNKNGTYEVG 398

  Fly   687 KWSNGGSDNLFSSVTSG--VSGS----SAV--ADAFASLSAVGGSVVSGAGAGG----STVSSES 739
            ....|..:.|||.:..|  |.||    .|:  :|...|...|...|.|.:|.||    ..|...|
Zfish   399 YTLKGEGEYLFSLILYGQPVRGSPFKLRAIKPSDVPQSPDDVKRRVKSPSGTGGHIRQKAVRRPS 463

  Fly   740 LLDLTNKLLSATIYPPKSQIKRQKMIYHCKFGEFGVMEGQFTEPSGVAVNAQNDIIVADTNNHRI 804
            .:..|.|        .|......::||  :.|..|..:|:||...|::.:....:||||:||..|
Zfish   464 SMYSTTK--------KKENPIEDELIY--RVGTRGREKGEFTNLQGISASISGRVIVADSNNQCI 518

  Fly   805 QIFDKEGRFKFQFGECGKRDSQLLYPNRVAVVRNSGDIIVTERSPTHQIQIYNQYGQFVRKFGAT 869
            |:|..:|:||.:||..|:...||..|..|||..| ||:||.:.. ...|.|::..|:|..|.||.
Zfish   519 QVFTNDGQFKARFGVRGRSPGQLQRPTGVAVDTN-GDVIVADYD-NRWISIFSPDGKFKNKIGAG 581

  Fly   870 ILQHPRGVTVDNKGRIIVVECKVMRVIIFDQNGNVLHKFG----------------CSKHLEF-- 916
            .|..|:||.||..|.||.|:.|...|.||..||.::.|||                |:...:|
Zfish   582 RLMGPKGVAVDRNGHIIAVDNKACCVFIFQSNGKLVTKFGARGTSDRQFAEKSGSKCALEQKFSK 646

  Fly   917 ------PNGVVVNDKQEIFISDNRAHCVKVFNYEGQYLRQIG----GEGITNYPIGVGINSNGEI 971
                  |:.|.||:|.||.::|...|.|||::.:|::|.:.|    |.|..|.|.||.::.||.|
Zfish   647 SGPGFSPHFVAVNNKNEIVVTDFHNHSVKVYSADGEFLFKFGSHGEGNGQFNAPTGVAVDVNGNI 711

  Fly   972 LIADNHNNFNLTIFTQDGQLISALESKVKHAQCFD-------VALMDDGSVVLA-SKDYRLYIYR 1028
            ::|| ..|..:.:|...|..:|.:.:..      |       :||..||.||:| |.::...:||
Zfish   712 IVAD-WGNSRIQVFDSAGSFLSYINTSA------DPLYGPQGLALTSDGHVVVADSGNHCFKVYR 769

  Fly  1029 YVQ 1031
            |:|
Zfish   770 YLQ 772

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brat	NP_001188842.2	BBOX	176..222	CDD:197662
		zf-B_box	328..366	CDD:279037	12/37 (32%)
		NHL_brat_like	760..1030	CDD:271329	103/305 (34%)
		NHL repeat	783..819	CDD:271329	14/35 (40%)
		NHL repeat	830..871	CDD:271329	16/40 (40%)
		NHL repeat	874..910	CDD:271329	18/51 (35%)
		NHL repeat	914..954	CDD:271329	16/51 (31%)
		NHL repeat	959..997	CDD:271329	12/37 (32%)
		NHL repeat	1002..1027	CDD:271329	9/32 (28%)
trim3b	XP_005155434.1	RING-HC_TRIM3	24..68	CDD:319682
		RING-HC finger (C3HC4-type)	27..67	CDD:319682
		BBOX	118..159	CDD:197662	15/48 (31%)
		BBC	166..291	CDD:128778	29/176 (16%)
		Filamin	333..424	CDD:306978	26/96 (27%)
		NHL_TRIM2_like	479..772	CDD:271330	104/303 (34%)
		NHL repeat	497..536	CDD:271330	15/38 (39%)
		NHL repeat	544..583	CDD:271330	16/40 (40%)
		NHL repeat	586..623	CDD:271330	18/36 (50%)
		NHL repeat	630..691	CDD:271330	17/60 (28%)
		NHL repeat	697..739	CDD:271330	13/48 (27%)
		NHL repeat	742..768	CDD:271330	8/25 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D133242at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24104
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2677
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	5.050