DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment brat and trim2

DIOPT Version :9

Sequence 1:	NP_001188842.2	Gene:	brat / 35197	FlyBaseID:	FBgn0010300	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	NP_001005680.1	Gene:	trim2 / 448181	XenbaseID:	XB-GENE-942459	Length:	760	Species:	Xenopus tropicalis

Alignment Length:	905	Identity:	210/905 - (23%)
Similarity:	346/905 - (38%)	Gaps:	219/905 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   179 CTACKSKCSDAVAKCFECQSYLCANC----VTAHEF-MHCFNGHNVCLIKGFEASTTGTP-LSVG 237
            |:.|..:..:  .|...|....|..|    :.||.. :.|    .||      ..|:..| ..|.
Frog    23 CSICLDRYKN--PKVLPCLHTFCERCLQNYIPAHSLTLSC----PVC------RQTSILPEKGVS 75

  Fly   238 SPSNNPASNEFKYASSLTMMLQQQQQLDSQQQQQQQQLLPAQPMSQLSKIVLAAAAQANSQEQQR 302
            :..||      .:.::|..:||:......::             |.:.:.|.|.||
Frog    76 ALQNN------FFITNLMDVLQRSPDNGIEE-------------SSILETVSAVAA--------- 112

  Fly   303 EDSIYGSLHPQQQQQQQQQQQRQLFCPRHKQELLKFSCRTCCILVCKECIVLEHSTGLHELENVQ 367
                                .:.|.||.|...:::|.|::|...:|::|...||:         :
Frog   113 --------------------GKPLSCPNHDGNVMEFYCQSCETAMCQDCTGGEHA---------E 148

  Fly   368 SPGMTTSTGSTANESALQTLLADMRGKIGEIVGIAGNSDQNLTKVKLQYQKAHNELNETHQFFAS 432
            .|.:........:::|||..|..::.::.||........:.:.::..|......|::.|......
Frog   149 HPTVPLKDVVEQHKAALQAQLDAVKKRLPEIDSALQCVSEIVNQLASQKTSIVEEIHSTFDDLQK 213

  Fly   433 MLDERKTELLKELETLYTAKVNSNNSWQQRSRDLID--KGLATCEAVERSPAPPSSLLTEALLLR 495
            .|:.||:.||.|||..|..|   :...|.:...||:  :.:.:|... .:.|......||.||::
Frog   214 TLNVRKSVLLMELEVNYGLK---HKVLQAQLDTLIEGQESIKSCTTF-TAQALNHGTETEVLLVK 274

  Fly   496 KSLEQQLQTGIQEMQLPF------EIEFMSNYQSIQAGVRNTFGYIRAN--SSDGGPTGMSLTSN 552
            |.:..:|.. :.|...|.      :::|:...:.::..:.|....:..|  :|:...||..|..:
Frog   275 KQMSDKLNE-LAEQDFPLQPHENDQLDFIVETEGLKKSIHNLGTILTTNAVASETVATGEGLRQS 338

  Fly   553 GHGKQPPIARPTQSASNSSASSAGSGHHGHHQQSHHHGHHNHHQTAHHQQLQAQSSLHGLGLGLS 617
            ..| ||.....|....:......||.:                                    :|
Frog   339 VIG-QPMSVTITTKDKDGELCKTGSAY------------------------------------IS 366

  Fly   618 GASLLDSSSSAGGAVGAFSNGGLLLGGRDRNALAVEQHFGELMPKRGGGGYTGSNGSATSAVAHY 682
            ........|...|.|....||              ...|...:|         :.|..|.::..|
Frog   367 AELFTPDGSVTDGEVVDNKNG--------------TYEFSYTIP---------TEGDFTLSLRLY 408

  Fly   683 NPYEKWSNGGSDNLFSSVTSGVSGSSAVADAFASLSAVGGSVVSGAGAGGSTVSSESLLDLTNKL 747
            :.:.|    ||......|.|        ||...:...|...|.|   .|...|..:::      .
Frog   409 DQHIK----GSPFKLKVVKS--------ADVSPTTEGVKRRVKS---PGSGHVKQKAV------K 452

  Fly   748 LSATIYPPKSQIKRQK------MIY----------HCKFGEFGVMEGQFTEPSGVAVNAQNDIIV 796
            ..|::|   |..||::      :|:          ....|..|..:|:||...|||.:....|::
Frog   453 RPASMY---STGKRKENPIEDDLIFRVGSRKDEDVRSLTGTKGRNKGEFTNLQGVAASTNGKILI 514

  Fly   797 ADTNNHRIQIFDKEGRFKFQFGECGKRDSQLLYPNRVAVVRNSGDIIVTERSPTHQIQIYNQYGQ 861
            ||:||..:|||..:|:||.:||..|:...||..|..|| |..|||||:.:.. ...:.|::..|:
Frog   515 ADSNNQCVQIFSNDGQFKSRFGIRGRSPGQLQRPTGVA-VHPSGDIIIADYD-NKWVSIFSADGK 577

  Fly   862 FVRKFGATILQHPRGVTVDNKGRIIVVECKVMRVIIFDQNGNVLHKFGCSKH--------LEFPN 918
            |..|.|:..|..|:||:||..|.||||:.|...|.||..||.::.:||...:        |:.|:
Frog   578 FKTKIGSGKLMGPKGVSVDRNGHIIVVDNKACCVFIFQPNGKIVTRFGSRGNGDKQFAGTLDGPH 642

  Fly   919 GVVVNDKQEIFISDNRAHCVKVFNYEGQYLRQIG----GEGITNYPIGVGINSNGEILIADNHNN 979
            ...||...||.::|...|.|||||.:|:::.:.|    |.|..|.|.||.::|||.|::|| ..|
Frog   643 FAAVNSNNEIIVTDFHNHSVKVFNQDGEFILKFGSNGEGNGQFNAPTGVAVDSNGNIIVAD-WGN 706

  Fly   980 FNLTIFTQDGQLISALESKVKHAQCFD-------VALMDDGSVVLA-SKDYRLYIYRYVQ 1031
            ..:.:|...|..:|.:.:..      |       ::|..||.||:| |.::...:|||:|
Frog   707 SRIQVFDGSGSFLSYINTSA------DPLYGPQGLSLTSDGHVVVADSGNHCFKVYRYLQ 760

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brat	NP_001188842.2	BBOX	176..222	CDD:197662	11/47 (23%)
		zf-B_box	328..366	CDD:279037	10/37 (27%)
		NHL_brat_like	760..1030	CDD:271329	101/305 (33%)
		NHL repeat	783..819	CDD:271329	15/35 (43%)
		NHL repeat	830..871	CDD:271329	14/40 (35%)
		NHL repeat	874..910	CDD:271329	17/35 (49%)
		NHL repeat	914..954	CDD:271329	15/43 (35%)
		NHL repeat	959..997	CDD:271329	13/37 (35%)
		NHL repeat	1002..1027	CDD:271329	8/32 (25%)
trim2	NP_001005680.1	RING	23..66	CDD:238093	11/54 (20%)
		BBOX	113..154	CDD:197662	12/49 (24%)
		BBC	161..287	CDD:128778	30/130 (23%)
		IG_FLMN	325..421	CDD:214720	24/159 (15%)
		Filamin	325..418	CDD:279024	24/156 (15%)
		NHL_TRIM2_like	483..760	CDD:271330	99/285 (35%)
		NHL repeat	501..540	CDD:271330	16/38 (42%)
		YncE	547..>751	CDD:225926	72/212 (34%)
		NHL repeat	548..587	CDD:271330	14/40 (35%)
		NHL repeat	590..627	CDD:271330	18/36 (50%)
		NHL repeat	634..679	CDD:271330	15/44 (34%)
		NHL repeat	685..727	CDD:271330	14/48 (29%)
		NHL repeat	730..756	CDD:271330	7/25 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D133242at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24104
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2677
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.050