DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment brat and wech

DIOPT Version :9

Sequence 1:	NP_001188842.2	Gene:	brat / 35197	FlyBaseID:	FBgn0010300	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	NP_001137614.1	Gene:	wech / 44653	FlyBaseID:	FBgn0259745	Length:	832	Species:	Drosophila melanogaster

Alignment Length:	1056	Identity:	231/1056 - (21%)
Similarity:	378/1056 - (35%)	Gaps:	344/1056 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 SASVSSSSSASSSSCSSSSSSSSSSSSSSSSTSGLSGC----GSTSSSVISANNVASSNGPGV-- 132
            |.:.|:::.|.||:.:.|...|.||::|:||...|:|.    .:...:|....||..|:.|..
  Fly    17 SNAPSANNVAHSSTANGSGGGSVSSNASNSSERLLAGILESFPAWDLNVGLLPNVGQSSPPRADF 81

  Fly   133 -IGSNLQSSNNGGNSGISSLVVGAGKGSNSSSNSSSSNTSANGSPPRCTACKSKCSDAVAKCFEC 196
             |.:.|...:..|:..|..:      ||.:.||...|..|:|.|...|..|:...|   .:|.||
  Fly    82 FINNFLGGLDTHGDFSIGPI------GSGARSNPKMSPESSNNSSISCGWCEVSAS---IRCLEC 137

  Fly   197 QSYLCANCVTAHEFMHCFNGHN-VCLIKGFEASTTGTPLSVGSPSN--NPASNEFKYASSLTMML 258
            ..::|.:|:..|......:.|: |.|.....||.||     ||..|  .|.|..|
  Fly   138 NEFMCNDCLREHRNSPLSSNHSIVSLPTPIGASPTG-----GSSVNAQTPPSGNF---------- 187

  Fly   259 QQQQQLDSQQQQQQQQLLPAQPMSQLSKIVLAAAAQANSQEQQREDSIYGSLHPQQQQQQQQQQQ 323

  Fly   188 ----------------------------------------------------------------- 187

  Fly   324 RQLFCPRHKQELLKFSCRTCCILVCKECIVLEHSTGLHELENVQS---------PGMTTST--GS 377
               .|..| .|:|::.|..|..|||:.|.:.||..  |...::||         .|...|:  |:
  Fly   188 ---ICDIH-NEMLRYVCDYCRKLVCQCCTLHEHKE--HSYASIQSFMVGSKEKLEGAIESSQVGT 246

  Fly   378 TANESALQTLLADMRGKIGEIVGIAGNSDQNLTKVKLQYQKAHNELNETHQFFASMLDERKTELL 442
            ...:|::...||.:|     ::      ::|.:::....:||..:       |...:::|:..||
  Fly   247 RCIKSSIDKALAFIR-----LI------ERNCSELSDNIRKAFRQ-------FIIAIEDRERFLL 293

  Fly   443 KELETLYTAKVNSNNSWQQRSRDLIDKGLATCEAVERSPAPPSSLLTEALLLRKSLEQ-----QL 502
            ..:|.|           :||...::...:|..::.....:..|.:|::......:::|     :|
  Fly   294 DFVEKL-----------RQRRLAILHDQMAGLKSALAGLSETSDMLSKVADNACNMDQIEIAMKL 347

  Fly   503 QTGIQEMQLPFEIEFMSNYQSIQ----------------AGVRNTFGYIRANSSDGGPTGMSLTS 551
            ..|.::|:     :|...|:.:|                ..:||..|.|..:..:     :.:.|
  Fly   348 TNGQRQME-----QFAGIYKDLQPKQEVFAFAPPDYSLLQDIRNQGGVILVDDKN-----LPIVS 402

  Fly   552 NGHGKQPPIARPTQSASNSSASSAGSGHHGHHQQSHHHGHHNHHQTAHHQQLQAQSSLHGLGLGL 616
            :.:|..|       |.|:.:|.:|.|                                    :|:
  Fly   403 SSNGIVP-------SVSSVNAVAAAS------------------------------------VGV 424

  Fly   617 SGASLLDSSSSAGGAVG--AFSNGGLLLGGRD--RNALAV-----------EQHF---GELMPKR 663
            .|        ...|.||  ..|||..|..|.:  .|.|:|           :..|   ..:|..|
  Fly   425 VG--------GVAGVVGGVGVSNGLDLAFGMNMPNNPLSVASSSVRRPLLRDNSFRIPSPIMQPR 481

  Fly   664 GGGGYTGSNGSATSAVAHYNPYEKWSNGG---SDNL-FSS--VTSGVSG---------SSAVADA 713
            ||.....|:|.:::|:       .|...|   |..| ||:  .|..:.|         |:|::.:
  Fly   482 GGSACGMSSGMSSAAL-------DWELNGLRSSPGLHFSAPRTTQAIPGCMDLVKVRNSNALSLS 539

  Fly   714 FASLSAVGGSVVSGAGAGGSTVSSESLLDLTNKLLSATIYPPKSQIKRQKMIYHCKFGEFGVMEG 778
            ||:.....|.|....|.....:....:.|..|..:.  ::.|...:|       .|||..||..|
  Fly   540 FATEGHEDGQVSRPWGLCVDKMGHVLVSDRRNNRVQ--VFNPDGSLK-------FKFGRKGVGNG 595

  Fly   779 QFTEPSGVAVNAQNDIIVADTNNHRIQIFDKEGRFKFQFGECGKRDSQLLYPNRVAVVRNSGDII 843
            :|..|:|:.|:..|.|||.|.:|||:|||...|.|..:||..||...|..||..|||  ||...|
  Fly   596 EFDLPAGICVDVDNRIIVVDKDNHRVQIFTASGVFLLKFGSYGKEYGQFQYPWDVAV--NSRRQI 658

  Fly   844 VTERSPTHQIQIYNQYGQFVRKFGATILQHPRGVTVDNKGRIIVVECKVMRVIIFDQNGNVLHKF 908
            |...|..|:||.::..|:|:|:                              |:||.:|.
  Fly   659 VVTDSRNHRIQQFDSEGRFIRQ------------------------------IVFDNHGQ----- 688

  Fly   909 GCSKHLEFPNGVVVNDKQEIFISDNRAHCVKVFNYE-GQYLRQIGGEGI----TNYPIGVGINSN 968
              :|.:..|.||.......|.:||...||:.:.:.: ...|...|.||.    .|.|.|:..:..
  Fly   689 --TKGIASPRGVCYTPTGNIIVSDFDNHCLYLIDPDINDILSVKGHEGSGFHEFNRPSGLCCDDE 751

  Fly   969 GEILIADNHNNFNLTIFTQDGQLISALESK------------VKHAQCFDVALMDDGSVVL---- 1017
            |.|::||:.|. .:.:|.|:...:..:|.:            .|...| |||:|.||.:|.
  Fly   752 GRIIVADSKNQ-RILVFNQNLDFMWDIEVRPSINPLMPPTLDEKDRTC-DVAIMPDGRIVFLIEL 814

  Fly  1018 ------ASKDYRLYIY 1027
                  .|..|:.:::
  Fly   815 SPDSKEGSNPYKRFVH 830

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brat	NP_001188842.2	BBOX	176..222	CDD:197662	11/46 (24%)
		zf-B_box	328..366	CDD:279037	13/37 (35%)
		NHL_brat_like	760..1030	CDD:271329	84/295 (28%)
		NHL repeat	783..819	CDD:271329	17/35 (49%)
		NHL repeat	830..871	CDD:271329	15/40 (38%)
		NHL repeat	874..910	CDD:271329	4/35 (11%)
		NHL repeat	914..954	CDD:271329	10/40 (25%)
		NHL repeat	959..997	CDD:271329	9/37 (24%)
		NHL repeat	1002..1027	CDD:271329	10/34 (29%)
wech	NP_001137614.1	BBOX	187..224	CDD:237988	14/117 (12%)
		iSH2_PI3K_IA_R	232..343	CDD:304922	22/139 (16%)
		YncE	<527..>740	CDD:225926	72/260 (28%)
		NHL_TRIM71_like	528..810	CDD:271324	91/331 (27%)
		NHL repeat	553..592	CDD:271324	8/47 (17%)
		NHL repeat	600..639	CDD:271324	18/38 (47%)
		WD40 repeat	603..640	CDD:293791	17/36 (47%)
		WD40 repeat	647..684	CDD:293791	16/68 (24%)
		NHL repeat	647..683	CDD:271324	16/67 (24%)
		WD40 repeat	692..736	CDD:293791	12/43 (28%)
		NHL repeat	692..733	CDD:271324	10/40 (25%)
		NHL repeat	742..772	CDD:271324	9/30 (30%)
		WD40 repeat	743..767	CDD:293791	7/24 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447038
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6741
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D133242at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24104
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.900