DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment brat and tn

DIOPT Version :9

Sequence 1:	NP_001188842.2	Gene:	brat / 35197	FlyBaseID:	FBgn0010300	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	NP_001137707.1	Gene:	tn / 37190	FlyBaseID:	FBgn0265356	Length:	1517	Species:	Drosophila melanogaster

Alignment Length:	1065	Identity:	224/1065 - (21%)
Similarity:	386/1065 - (36%)	Gaps:	358/1065 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 DEYTGGSSVKSRSEVTVINGHHPISASVS-------SSSSASSSSCSSSSSSSSSSSSSSSSTSG 107
            :||| ...::|:.         |:||.|:       |.||.||:|..||:||:::::.:::|||.
  Fly   724 EEYT-EEEIESKP---------PVSAQVAAVKKTQRSGSSDSSASTESSASSAAAAAVAATSTSA 778

  Fly   108 LSGCGSTSSSVISANNVASSNGPGVIGSNLQSSNN---------------GGNSGISSLVVGAGK 157
            .:...:||||     |..|.|......|...::.:               ..:|..|:....|.|
  Fly   779 TAAAPATSSS-----NSTSQNAKAPSSSRYSTARDTTAVPEKKPFVSRFLPQHSTASTTNGSADK 838

  Fly   158 GSNSSSNSSSSNTSANGSPPRCTACKSKCSDAVAKCFECQSYLCANCVTAHEFMHCFNGHNVCLI 222
            ....||:||...||:..........|:|.|..
  Fly   839 KKAESSSSSEEETSSESESESEPETKAKSSAT--------------------------------- 870

  Fly   223 KGFEASTTGTPLSVGSPSNNPASNEFKYASSLTMMLQQQQQLDSQQQQQQQQLLPAQPMSQLS-- 285
                :|||.|     ..:.|.|::....|||.|.....:.:|::::..:......|...|..:
  Fly   871 ----SSTTNT-----KSTPNSAASSTTAASSSTTSGSYRDRLEARRASRDDSSSTAAGRSSYATP 926

  Fly   286 --------------KIVLAAAAQANSQEQQREDSIYGSLHPQQQQQQQQQQQRQLFCPRHKQELL 336
                          :.....|....|:.:.|..|..||.:..:            |..:.|...:
  Fly   927 SSSGYGSGSGTTGGRTRAVPAPHHTSESEDRYGSGTGSSYTSR------------FLNKSKSSAI 979

  Fly   337 KFSCRTCCILVCKECIVLEHSTGLHELENVQSPGMTTSTGSTANESALQTLLADMRGKIGEIVGI 401
                                         |..|.::|.|.|...::                .|.
  Fly   980 -----------------------------VTQPSLSTPTASFDEDA----------------TGT 999

  Fly   402 AGNSDQNLTKVKLQYQKAHNELNETHQFFASMLDERKTELLKELETLYTAKVNSNNSWQQRSRDL 466
            ..:||......:.:|               ..:.||:|.|         |:..|::.:.....||
  Fly  1000 GDDSDSRYGTGRSRY---------------LAMKERRTRL---------ARSRSSHQFGNDDEDL 1040

  Fly   467 IDKGLATCEAVERSPAPPSSLLTEALLLRKSLEQQLQTGIQEMQLPFEIEFMSNYQSIQAGVRNT 531
            .:            |..|:::...|.|..:....
  Fly  1041 DE------------PVSPTTVSPSAYLASRCAYS------------------------------- 1062

  Fly   532 FGYIRANSSDGGPTGMSLTSNGHGKQPPIARPTQSASNSSASSAGSGHHGHHQQSHHHGHHNHHQ 596
             ||        |.:.:|.:.:.|.        .:|..||..:..|:|
  Fly  1063 -GY--------GSSDLSRSRSSHA--------LKSRDNSPITDRGAG------------------ 1092

  Fly   597 TAHHQQLQAQSSLHGLGLGLSGASLLDSSSSAGGAVGAFS--------------NGGLLLGGRDR 647
                   .::||      ||.|:|..||..  |.|:.:::              :.|.....||.
  Fly  1093 -------SSRSS------GLGGSSTTDSKD--GEALSSWARYLKNKYGNKSSKDSAGSSGSARDT 1142

  Fly   648 NALAVEQHFGELMPKRGGGGYTGSNGSATSAVAHYNPYEKWSNGGSDNLFSSVTSGVSGSSAVAD 712
            :|                |..|.|:.:|:|:.||.              :.|.|||.||.|..:|
  Fly  1143 HA----------------GSSTSSSAAASSSHAHG--------------YGSGTSGSSGRSTASD 1177

  Fly   713 AFASLS---------AVGGSVVSGA--GAGGST----VSSESLLDLTNKLLSATIYPPKSQIKRQ 762
            ....||         .:..|...|:  |.|..|    .::.:...:|.   :|...|.:..::::
  Fly  1178 VSRRLSLGLPLRQANELASSDDDGSKNGLGSPTSPTVAAAVAAAGITG---AAGTIPKQVYLRKR 1239

  Fly   763 KMIYHCKFGEFGVMEGQFTEPSGVAVNAQNDIIVADTNNHRIQIFDKEGRFKFQFGECGKRDSQL 827
            :.::  :.|..|...|.||.|.|:||...|.|:|||::|||:|:||..|.|..:|||.|..:.:.
  Fly  1240 QQLF--QLGGRGSEPGSFTWPRGLAVGPDNSIVVADSSNHRVQVFDSNGIFVKEFGEYGNGEGEF 1302

  Fly   828 LYPNRVAVVRNSGDIIVTERSPTHQIQIYNQYGQFVRKFGAT-----ILQHPRGVTVDNKGRIIV 887
            .....|||.| .|..|:.:|. .|:||:.:..|:|:|.||:.     ...:|.|||.|..|.|.|
  Fly  1303 DCLAGVAVNR-IGQYIIADRY-NHRIQVLDPQGRFLRAFGSQGTADGKFNYPWGVTTDALGFIYV 1365

  Fly   888 VECKVMRVIIFDQNGNVLHKFG-CSK---HLEFPNGVVVNDKQEIFISDNRAHCVKVFNYEGQYL 948
            .:.:..||.:|..:|:.:.||| |.:   .||.|:.:.|::...:.:||:..|.:::|:..|:.|
  Fly  1366 CDKENHRVQVFQSDGSFVGKFGSCGRGEGQLEHPHYIAVSNTNRVIVSDSNNHRIQIFDVNGKVL 1430

  Fly   949 RQIGGEGITN----YPIGVGINSNGEILIADNHNNFNLTIFTQDGQLISAL------ESKVKHAQ 1003
            ..:||||..:    :|.||.::..|.|.:||:.|| .:.||..||..:...      :|:.|..:
  Fly  1431 STVGGEGSDDGQFKFPRGVAVDDQGYIFVADSGNN-RIQIFNPDGSFLKTFGSWGSGDSEFKGLE 1494

  Fly  1004 CFDVALMDDGSVVLASKD-YRLYIY 1027
              .||:|.:|::::..:: :|:.::
  Fly  1495 --GVAIMSNGNILVCDRENHRVQVF 1517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brat	NP_001188842.2	BBOX	176..222	CDD:197662	3/45 (7%)
		zf-B_box	328..366	CDD:279037	1/37 (3%)
		NHL_brat_like	760..1030	CDD:271329	91/288 (32%)
		NHL repeat	783..819	CDD:271329	18/35 (51%)
		NHL repeat	830..871	CDD:271329	15/45 (33%)
		NHL repeat	874..910	CDD:271329	15/36 (42%)
		NHL repeat	914..954	CDD:271329	11/39 (28%)
		NHL repeat	959..997	CDD:271329	13/43 (30%)
		NHL repeat	1002..1027	CDD:271329	5/25 (20%)
tn	NP_001137707.1	RING	9..54	CDD:238093
		zf-B_box	94..>122	CDD:279037
		iSH2_PI3K_IA_R	131..231	CDD:304922
		NHL_TRIM71_like	1234..1517	CDD:271324	91/289 (31%)
		YncE	1253..>1517	CDD:225926	89/268 (33%)
		NHL repeat	1258..1297	CDD:271324	20/38 (53%)
		WD40 repeat	1261..1304	CDD:293791	19/42 (45%)
		NHL repeat	1305..1344	CDD:271324	15/40 (38%)
		WD40 repeat	1345..1377	CDD:293791	10/31 (32%)
		NHL repeat	1352..1388	CDD:271324	14/35 (40%)
		NHL repeat	1396..1436	CDD:271324	11/39 (28%)
		WD40 repeat	1402..1439	CDD:293791	11/36 (31%)
		NHL repeat	1445..1475	CDD:271324	12/30 (40%)
		WD40 repeat	1446..1485	CDD:293791	13/39 (33%)
		NHL repeat	1491..1517	CDD:271324	6/27 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447042
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D133242at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24104
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2677
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.980